Design, Synthesis and in Silico Molecular Docking Studies of Adamantanyl hydrazinylthiazoles as Potential Anti-diabetic Agents.

Diabetes mellitus is a widespread disease that poses a major threat to millions of people. To address this issue, we have synthesized seventeen new 4-(adamantan-1-yl)-(2-(arylidene)hydrazinyl)thiazoles via Hantzsch synthetic approach. The molecular structures of all the compounds were confirmed using spectroscopic techniques.

Seed priming with alpha-tocopherol alleviates microplastic stress in Brassica rapa through modulations in morphological, physiological and biochemical attributes.

Microplastics (MPs) have been regarded as emerging pollutants globally, and understanding of the injurious impacts of MPs on food crops is still scarce. MPs toxicity can disrupt the growth and physic-chemical characteristics of turnip seedlings. Hence, sustainable remediation techniques by employing growth regulators can alleviate harmful impacts and confer MPs tolerance in vegetables.

A comprehensive review on advanced trends in treatment technologies for removal of Bisphenol A from aquatic media.

Toxic environmental pollutants are considered to be posed a major threat to human and aquatic systems. The fast advancement of the petrochemical and chemical industries has woken up rising worries concerning the pollution of water by contaminants including phenolic Bisphenol A (BPA), an endocrine-disrupting chemical (EDC). The intermediate BPA used in synthesis of certain plastics, polycarbonate polymers, polysulfone, and epoxy resins of various polyesters.

Nudging recommendation algorithms increases news consumption and diversity on YouTube.

Recommendation algorithms profoundly shape users' attention and information consumption on social media platforms. This study introduces a computational intervention aimed at mitigating two key biases in algorithms by influencing the recommendation process. We tackle , or algorithms creating narrow nonnews and entertainment information diets, and , or algorithms directing the more strongly partisan users to like-minded content.

SELF-REPORTED MULTI-MORBIDITY WITH TUBERCULOSIS: DATA FROM THE KHYBER PAKHTUNKHWA INTEGRATED POPULATION HEALTH SURVEY (KPIPHS) IN PAKISTAN.

Background: With the rise of non-communicable diseases (NCDs) in a country that is already facing high tuberculosis (TB) burden, TB multi-morbidity is likely to pose a significant public health challenge in Pakistan. Data were analysed to determine the prevalence of TB and explore the distribution and determinants of multi-morbidity associated with TB in the population of Khyber Pakhtunkhwa -a province of Pakistan.

Methods: This is a secondary analysis of data gathered as part of the KPIPHS survey conducted in 2016-17 in both the rural and urban areas of Khyber Pakhtunkhwa, Pakistan.

USE OF DIFFERENT ANTHROPOMETRIC TOOLS IN GENDER ANALYSIS OF MALNUTRITION IN DIVISION BAHAWALPUR.

Previous studies highlighted that CIAF is the better tool for malnutrition assessment which screen more children compared to other anthropometric approaches like MUAC, BMI for age, and conventional indices (Stunting, Wasting and Underweight). In the literature, none of the studies has mentioned CIAF performance by gender in comparison with other anthropometric approaches. The study solves this puzzle, of whether CIAF has the same performance in gender analysis too or not.

Kaempferol Synergistically Enhances Cisplatin-induced Apoptosis and Cell Cycle Arrest in Colon Cancer Cells.

Colon cancer remains a significant global health concern, necessitating the continuous exploration of novel therapeutic strategies. Cisplatin is a first-line chemotherapy medication that is frequently used to treat patients for a variety of malignancies, including colon cancer. However, a major obstacle to its clinical usefulness is acquired resistance.

Structure-Activity Relationship of Hydrazinylthiazole-5-Carbaldehydes as Potential Anti-Diabetic Agents.

Diabetes is an emerging threat to the world due to large number of deaths reported within the last decade. To overcome its spread and complications, herein, we reported synthesis and anti-diabetic potential of twelve novel 2-[(arylidenyl)methylidene]hydrazinyl-1,3-thiazole-5-carbaldehydes (3 a-l). All compounds have shown good to excellent α-amylase inhibitory activity, among them ortho substituted analogues, the compound 3 a (IC=14.

Synthesis, anti-diabetic profiling and molecular docking studies of 2-(2-arylidenehydrazinyl)thiazol-4(5)-ones.

To synthesize novel more potent anti-diabetic agents. A simple cost effective synthetic strategy was used to synthesize 2-(2-arylidenehydrazinyl)thiazol-4(5)-ones. Fifteen new 2-(2-arylidenehydrazinyl)thiazol-4(5)-ones were established to check their anti-diabetic potential.

Assessing rural land use in contemporary China: Data compilation and methodology.

In rural areas, land use decisions are not only shaped by economic considerations but also deeply influenced by cultural and social factors. The objective of this research is to examine the complex and diverse aspects of making decisions about how land is used in rural communities, specifically by investigating the influence of cultural and social elements. Using empirical data and rigorous analysis, this research examine how traditional practices, social norms, and community dynamics influence land use patterns.

Consumption of proton pump inhibitors in outpatients of Gastroenterology Clinics in Khyber Pakhtunkhwa: evidence of inexpedient use.

Introduction: Proton pump inhibitors (PPIs) are effective drugs used for multiple gastrointestinal complications. They are commonly used in both hospitalised and outpatients. However, little is known about its utilisation pattern in ambulatory patients.

Zn solubilizing bacteria (ZSB) mitigate toxicity of silver and Titanium dioxide nanoparticles in Mung bean by increasing photosynthetic pigment content.

Zn-deficiency, a global health challenge affects one-third of the world population. Zn-biofertilizer offer an efficient and cost-effective remedy. As Zn-biofertilizer can improve plant growth and grain's Zn-content ensuring improved dietary Zn-supply.

A first principles based prediction of electronic and nonlinear optical properties towards cyclopenta thiophene chromophores with benzothiophene acceptor moieties.

In the current work, organic cyclopenta-thiophene (CPT) based derivatives (FICR and FICD1-FICD5) were designed by the modulation of end-capped acceptor group of the reference molecule i.e., FICR, to explore their nonlinear optical (NLO) response.

Evidence from China's shipping sector on the impact of fiscal measures in enabling a low-carbon economic transition.

The Green Economy Initiative aims to achieve economic development while minimizing carbon emissions by implementing a low-carbon economy across all sectors. It is noteworthy that ships play a significant role in global commodity transportation, accounting for approximately 80-90 percent. However, this also leads to a surge in fossil fuel consumption and alarming pollution levels.

How causality impacts the renewable energy, carbon emissions, and economic growth nexus in the South Caucasus Countries?

Renewable energy is essential for boosting economic expansion and lowering carbon dioxide emission (CO) to achieve carbon neutrality. This study's objective is to investigate the relationship between the use of renewable energy, economic growth, and CO for South Caucasus Countries. For analysis purposes, time series methods were applied on the panel data.

Performance of angle shear connectors for U-shaped steel concrete infilled composite beams.

The current design codes i.e. AISC 360-16, CSA-S16-19, EC-04 etc.

A Systematic Review of Artificial Intelligence Applications in the Management of Lung Disorders.

This systematic review examines the transformative impact of artificial intelligence (AI) in managing lung disorders through a comprehensive analysis of articles spanning 2014 to 2023. Evaluating AI's multifaceted roles in radiological imaging, disease burden prediction, detection, diagnosis, and molecular mechanisms, this review presents a critical synthesis of key insights from select articles. The findings underscore AI's significant strides in bolstering diagnostic accuracy, interpreting radiological imaging, predicting disease burdens, and deepening the understanding of tuberculosis (TB), chronic obstructive pulmonary disease (COPD), silicosis, pneumoconiosis, and lung fibrosis.

Synthesis of hydrazinyl-thiazole ester derivatives, trypanocidal and leishmanicidal activities.

To synthesize novel more potent trypanocidal and leishmanicidal agents. Hantzsch's synthetic strategy was used to synthesize 1,3-thiazole-4-carboxylates and their -benzylated derivatives. 28 new thiazole-carboxylates and their -benzylated derivatives were established to test their trypanocidal and leishmanicidal activities.

The influence of environment and Earnings on Prolonged existence and human fertility: A Deeper Dive into Asia's environmentally vulnerable nations.

This study inspects the impact of environmental deterioration and income on longevity and fertility in Asian countries, specifically the nations that are highly vulnerable to extreme weather. The study examines the data, covering two decades from 2000 to 2019. The empirical conclusions of the panel ARDL-PMG and the CS-ARDL econometric models indicate that environmental degradation leads to a decline in birth rate and life expectancy, while a rising income has a significant influence over longevity.

Auditing YouTube's recommendation system for ideologically congenial, extreme, and problematic recommendations.

Algorithms of social media platforms are often criticized for recommending ideologically congenial and radical content to their users. Despite these concerns, evidence on such filter bubbles and rabbit holes of radicalization is inconclusive. We conduct an audit of the platform using 100,000 sock puppets that allow us to systematically and at scale isolate the influence of the algorithm in recommendations.

Promising impact of push-pull configuration into designed octacyclic naphthalene-based organic scaffolds for nonlinear optical amplitudes: a quantum chemical approach.

In opto-electronics, non-fullerene (NF) derivatives are regarded as efficient non-linear optical (NLO) materials. The present investigation was based on designing NF naphthalene-based derivatives (PCMD1-D9) with D-π-A configuration from PCMR. DFT analysis at M06/6-311G (d,p) level was accomplished to explore the photonic behavior of PCMD1-D9 compounds.