Publications by authors named "Harold Mendoza"
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis.
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- Focused ultrasound (FUS) can temporarily disrupt the blood-brain barrier (BBB) to enhance targeted drug delivery and improve imaging of brain metabolism.
- In a study with rodents, using hyperpolarized [1-C]pyruvate showed increased carbon signals and higher production of metabolic products like lactate and bicarbonate in areas where the BBB was disrupted by FUS.
- Additionally, hyperpolarized [1-C]glycerate demonstrated enhanced delivery to regions treated with FUS, indicating that this method may be valuable for researching metabolic pathways and neurological disorders.
Background: Delayed-release dimethyl fumarate (DMF) may be a therapeutic option for patients with relapsing-remitting multiple sclerosis (RRMS) who are treated with natalizumab and require a change in therapy. However, there is limited information regarding predictors of favorable treatment outcomes in patients switching from natalizumab to DMF. Clinical practices and sequencing protocols vary.
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