Pupil staging and EEG measurement of sleepiness.

The goal of this multi-method study was to examine the validity (accuracy) of the pupillometric Alertness Level Test (ALT) as a physiologic measure of sleepiness. The study used a pooled-time series-correlation design with 16 untreated narcolepsy (8 F, 8 M), 16 untreated obstructive sleep apnea (OSA) (7 F, 9 M) and 16 healthy control (8 F, 8 M) subjects. Participants underwent EEG/polysomnography testing using standard Multiple Sleep Latency Test electrode placement concurrent with the 15 min pupillometric ALT.