Publications by authors named "Harmon E"

The experience of tinnitus can range from inducing annoyance to debility. In the US, tinnitus is estimated to affect 1 in 10 adults, though it is known to be underreported. Often dismissed, tinnitus can be a precursor for treatable pathologies.

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  • Trichomonas vaginalis is a one-celled parasite that causes trichomoniasis, the most common nonviral STD worldwide, and it uses mimicry of human proteins to evade the immune system.
  • The parasite produces a protein called TvMIF, which helps it survive stress, boosts prostate cell growth, and triggers inflammation, paralleling the effects of human MIF.
  • Recent studies have revealed the structure of TvMIF, showing it has a similar shape to human versions, suggesting that understanding this protein can aid in developing new drugs.
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  • Onchocerca volvulus is responsible for serious health issues, including blindness and neurological diseases, and current treatments like ivermectin can't be safely used in pregnant women or those co-infected with Loa loa.
  • Researchers at the Seattle Structural Genomics Center for Infectious Disease have successfully produced and crystallized a potential drug target called OvMIF-1, which has a unique jellyfish-like structure.
  • The study suggests that deleting its N-terminal tag could reveal a larger cavity for drug targeting, indicating the need for further analysis to confirm the true biological structure of OvMIF-1.
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Background: The 2019 coronavirus (COVID-19) outbreak was declared a global pandemic in March 2020. It quickly spread across all continents, causing significant social, environmental, health, and economic impacts. During the pandemic, there has been consideration of repurposing and repositioning of medications, such as corticosteroids, for the treatment of hospitalised COVID-19 patients.

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  • - Iatrogenic mitral stenosis is an uncommon complication that can occur after the MitraClip procedure, with few treatment options available.
  • - The text discusses a specific case where real-time echocardiographic and hemodynamic data were used to explore a new treatment approach.
  • - It suggests that creating an interatrial septostomy could be a potential percutaneous management option for patients facing this complicated condition.
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A new patient transfer assessment scale for use in inpatient rehabilitation facilities (IRFs) is warranted to assess level of assistance, adaptations needed for success, and movement strategies. This study presents initial psychometric analyses for the Comprehensive Inpatient Transfer Tool (CITT). CITT items were developed through interdisciplinary team discussions.

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  • * The V-Wave interatrial shunt system is being studied as a potential solution; it aims to improve heart function by shunting blood between the atria, thereby reducing pressure in the left atrium.
  • * The V-Wave Shunt MitraClip Study is assessing the safety and efficacy of implanting this shunt during the MitraClip surgery, with results expected in late 2024 after following participants for up to 5 years.
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  • The study highlights the public health concern of leptospirosis, particularly in underdeveloped areas, but also examines its presence in developed subtropical coastal ecosystems like the Pensacola Bay System.
  • The research involved analyzing 132 water samples from various locations, focusing on fecal indicator bacteria (FIB) and using qPCR to identify the distribution of leptospirosis.
  • Results indicated a seasonal link between rainfall and increased levels of fecal bacteria and leptospirosis, emphasizing the effectiveness of qPCR for detecting pathogens in both natural and urban aquatic environments.
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Purpose: Effective pain management is vital for hip fracture recovery, yet the factors influencing pain reporting and pain medication use during inpatient rehabilitation for hip fractures are not well understood. This observational study aimed to (a) determine how cognitive abilities, expressive and receptive language abilities, and age are related to average daily pain intensity and analgesic use and (b) how average daily pain intensity and analgesic use are related to length of stay and functional outcomes in rehabilitation.

Design: Data were retrospectively obtained from 163 patients recovering from unilateral trochanteric fractures of the femur.

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Objective: To determine clinically important differences (CIDs) on Section GG physical functioning scores on the Centers for Medicare and Medicaid Services (CMS) Inpatient Rehabilitation Facility Assessment Instrument (IRF-PAI) for patients with stroke, using anchor and distribution-based approaches.

Design: Pilot prospective observational cohort study.

Setting: Inpatient rehabilitation facility.

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This paper presents two studies in which a peer-assisted learning condition was compared to an individual learning condition. The first study used the paired-associates learning task and the second study used an incrementally more complex task-the remote associate test. Participants in the peer-assisted learning condition worked in groups of four.

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Objective: To validate Sections GG (Self-Care and Mobility Assessment), B (Hearing, Speech, and Vision), and C (Cognitive Patterns) of the Centers for Medicare and Medicaid Services Inpatient Rehabilitation Facility Patient Assessment Instrument (CMS-IRF PAI) Version 1.4 in comparison with Functional Independence Measure (FIM) motor subscale (FIMm) and cognitive subscale (FIMc).

Design: Retrospective cohort.

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Background: The profession of nursing has recognized the lack of diversity in nursing leadership. Nurses of color represent fewer than 20% of leadership roles in nursing administration, education, and professional organizations. Efforts are needed to identify and implement strategies to increase the representation of nurses of color in positions of high influence.

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Background: Although the prognosis and management of severe aortic stenosis has been extensively studied, the risk stratification and outcomes of patients with moderate aortic stenosis remain elusive.

Methods: This study included 674 patients from the Cleveland Clinic Health System with moderate aortic stenosis (aortic valve area, 1-1.5 cm; mean gradient, 20-40 mm Hg; and peak velocity <4 m/s) and an NT-proBNP (N-terminal pro-B-type natriuretic peptide) level within 3 months of index diagnosis.

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Purpose: The aim of this study was to evaluate the ability of the Hester Davis Scale (HDS), Section GG, and facility fall risk assessment scores to predict patients who fall during inpatient rehabilitation.

Design: This study was an observational quality improvement project.

Methods: Nurses administered the HDS in parallel to the facility's current fall risk assessment and Section GG of the Centers for Medicare & Medicaid Services Inpatient Rehabilitation Facility Patient Assessment Instrument.

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Developmental plasticity can occur at any life stage, but plasticity that acts early in development may give individuals a competitive edge later in life. Here, we asked if early (pre-feeding) exposure to a nutrient-rich resource impacts hatchling morphology in Mexican spadefoot toad tadpoles, . A distinctive carnivore morph can be induced when tadpoles eat live fairy shrimp.

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: Not all labor and delivery floors are equipped with ultrasound machines which can serve the needs of both obstetricians and anesthesiologists. This cross-sectional, blinded, randomized observational study compares the image resolution (RES), detail (DET), and quality (IQ) acquired by a handheld ultrasound, the Butterfly iQ, and a mid-range mobile device, the Sonosite M-turbo US (SU), to evaluate their use as a shared resource. : Seventy-four pairs of ultrasound images were obtained for different imaging purposes: 29 for spine (Sp), 15 for transversus abdominis plane (TAP) and 30 for diagnostic obstetrics (OB) purposes.

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Microglia are key mediators of inflammatory responses within the brain, as they regulate pro-inflammatory responses while also limiting neuroinflammation via reparative phagocytosis. Thus, identifying genes that modulate microglial function may reveal novel therapeutic interventions for promoting better outcomes in diseases featuring extensive inflammation, such as stroke. To facilitate identification of potential mediators of inflammation, we performed single-cell RNA sequencing of aged mouse brains following stroke and found that was significantly up-regulated, particularly in microglia.

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High energy photons (λ < 400 nm) are frequently used to initiate free radical polymerizations to form polymer networks, but are only effective for transparent objects. This phenomenon poses a major challenge to additive manufacturing of particle-reinforced composite networks since deep light penetration of short-wavelength photons limits the homogeneous modification of physicochemical and mechanical properties. Herein, the unconventional, yet versatile, multiexciton process of triplet-triplet annihilation upconversion (TTA-UC) is employed for curing opaque hydrogel composites created by direct-ink-write (DIW) 3D printing.

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Purpose Of Review: To review myocarditis and pericarditis developing after COVID-19 vaccinations and identify the management strategies.

Recent Findings: COVID-19 mRNA vaccines are safe and effective. Systemic side effects of the vaccines are usually mild and transient.

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Background: The Brief Interview for Mental Status (BIMS) is the Centers for Medicare and Medicaid Services' primary cognitive assessment for multiple health care settings. However, research suggests that the BIMS has low sensitivity in detecting mild cognitive impairment in community samples and nursing home residents.

Objective: To determine the sensitivity of the BIMS in identifying patients with mild or moderate cognitive impairments in an inpatient rehabilitation setting and the relationship of BIMS and Montreal Cognitive Assessment (MoCA) scores with rehabilitation outcomes.

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Background: Palliative ventilator withdrawal (PVW) involves removal of mechanical ventilation in patients not expected to survive to allow a peaceful death. This process traditionally occurs in Intensive Care Units (ICU) and recently has evolved to occur in Inpatient Hospice and Palliative Care Units (IPU).

Objectives: To describe the process and response of patients undergoing PVW in an IPU setting.

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