Microsurgical Semilunar Bilaminar Technique Halts Progression of Marginal Tissue Recession by Soft Tissue Phenotypic Modification-A Case Report With 3-Year Follow-Up.

Phenotype modification therapy using the novel semilunar flap with xenogeneic collagen matrix improves gingival phenotype, root coverage and increased keratinized tissue width. It also halts the progression of recession, enhances tissue resilience and improved plaque control sustainable over 3 years. Collagen matrix avoids second site surgery and hence less morbidity.

"Liver Clots" in Periodontology: A 10-Year Clinical Experience.

Objectives: "Liver clots" are an uncommon complication following periodontal surgery, characterized by their distinctive gelatinous consistency and color resembling 'liver' tissue. Despite anecdotal reports, there is a lack of comprehensive evidence in the literature regarding its incidence, etiopathogenesis and optimal management strategies. This study aimed to address this knowledge gap by retrospectively analyzing cases to provide insights into this unusual post-operative complication.

Correction to "Scalable Inhibitors of the Nsp3-Nsp4 Coupling in SARS-CoV-2".

[This corrects the article DOI: 10.1021/acsomega.2c06384.

Effectiveness of vestibular incision subperiosteal tunnel access technique: A systematic review and meta-analysis.

Vestibular Incision Subperiosteal Tunnel Access (VISTA) root coverage technique has experienced a surge in popularity in recent times. The methodology employed in this study is characterized by its minimally invasive nature, utilizing a single incision. The primary objective of this systematic review was to assess the effectiveness of the VISTA approach for achieving root coverage.

Indian Academy of Pediatrics Revised Guidelines on Evaluation, Prevention and Management of Childhood Obesity.

Justification: The last guidelines for pediatric obesity were released in 2004 by Indian Academy of Pediatrics (IAP). Since then, there has been an alarming increase in prevalence and a significant shift in our understanding in the pathogenesis, risk factors, evaluation, and management of pediatric obesity and its complications. Thus, it was decided to revise and update the previous recommendations.

Multiphase simulation of sustainable nanoenhanced ionic liquid coolants for improved thermal performance in Ti-6Al-4V alloy drilling.

Extensive research has been conducted by the manufacturing industry to enhance the efficiency of drilling processes by focusing on the utilization of nanoenhanced cutting fluids that possess excellent heat conductivity. Due to their eco-friendliness and adaptability of physical and chemical properties, ionic fluids offer enormous potential for application as cutting fluids. This study investigates the computational fluid dynamics analysis of the heat transfer performance of various ionanofluid pairs dispersed with nanoparticles as cutting fluids in the drilling process using Ansys Fluent software.

Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function.

Leukotrienes, a class of inflammatory bioactive lipids, are well studied in the periphery, but less is known of their importance in the brain. We identified that the enzyme leukotriene A4 hydrolase (LTA4H) is expressed in healthy mouse neurons, and inhibition of LTA4H in aged mice improves hippocampal dependent memory. Single-cell nuclear RNA sequencing of hippocampal neurons after inhibition reveals major changes to genes important for synaptic organization, structure, and activity.

A mathematical model for thrombotic risk assessment in type 2 diabetes.

Hyperglycaemia is known to alter the circulating lipids in diabetics. Combinatorial effect of synthesis of lipids and dietary lipids leads to atherosclerosis. Uncontrolled diabetes is linked with the cardiovascular outcome.

The people behind the papers - Rohit Krishnan Harish and Michael Brand.

The growth factor Fgf8a has been suggested to act as a morphogen during zebrafish gastrulation, spreading from a localized source to form a concentration gradient and impart positional information to cells along a tissue field. In a new paper in Development, Michael Brand and colleagues directly visualize the endogenous Fgf8a gradient in the developing zebrafish embryo. We caught up with the first author Rohit Krishnan Harish, and his PhD supervisor Michael Brand, Professor at the Center for Regenerative Therapies (CRTD) at TU Dresden.

Real-time monitoring of an endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation.

Morphogen gradients impart positional information to cells in a homogenous tissue field. Fgf8a, a highly conserved growth factor, has been proposed to act as a morphogen during zebrafish gastrulation. However, technical limitations have so far prevented direct visualization of the endogenous Fgf8a gradient and confirmation of its morphogenic activity.

Comprehensive review on ideas, designs and current techniques in solar dryer for food applications.

Due to the expansion of residents, the consumption of non-renewable energy increased enormously, thus indirectly increasing pollution and affecting the surroundings. To reduce pollutions in the surroundings, it is recommended to choose non-conventional energy sources. By satisfying this, we can probably decrease the non-renewable sources of energy, by consuming the solar power in day-to-day life in the application of food drying process.

Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging.

Peripheral administration of tissue inhibitor of metalloproteinases 2 (TIMP2), a protein inhibitor of matrix metalloproteinases (MMPs), has previously been shown to have beneficial effects on cognition and neurons in aged mice. Here, to better understand the potential of recombinant TIMP2 proteins, an IgG4Fc fusion protein (TIMP2-hIgG4) was developed to extend the plasma half-life of TIMP2. Following one month of administration of TIMP2 or TIMP2-hIgG4 via intraperitoneal injections, 23-month-old male C57BL/6J mice showed improved hippocampal-dependent memory in a Y-maze, increased hippocampal gene expression, and increased excitatory synapse density in the CA1 and dentate gyrus (DG) of the hippocampus.

Further evidence of biallelic variants in KCNK18 as a cause of intellectual disability and epilepsy with febrile seizure plus.

Introduction: KCNK18 , a potassium channel subfamily K member 18 (MIM*613655), encodes for TWIK-related spinal cord K+ channel (TRESK) and is important for maintaining neuronal excitability. Monoallelic variants in KCNK18 are known to cause autosomal dominant migraine, with or without aura, susceptibility to, 13 (MIM#613656). Recently, biallelic missense variants in KCNK18 have been reported in three individuals from a non-consanguineous family with intellectual disability, developmental delay, autism spectrum disorder (ASD), and seizure.

CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain.

Targeting immune-mediated, age-related, biology has the potential to be a transformative therapeutic strategy. However, the redundant nature of the multiple cytokines that change with aging requires identification of a master downstream regulator to successfully exert therapeutic efficacy. Here, we discovered CCR3 as a prime candidate, and inhibition of CCR3 has pro-cognitive benefits in mice, but these benefits are not driven by an obvious direct action on central nervous system (CNS)-resident cells.

Envelope coronally advanced flap with site-specific bilaminar acellular dermal matrix or connective tissue graft for management of multiple marginal tissue recessions: A retrospective analysis of cases.

Background: A proper case selection and decision making is essential for management of multiple marginal tissue recessions (MTR) using a conventional or bilaminar approach. Coronally advanced flap (CAF) is one of the commonly used methods for management of MTR. CAF has been advocated in combination with soft tissue grafts as bilaminar technique, which had showed significant success in terms of root coverage.

Scalable Inhibitors of the Nsp3-Nsp4 Coupling in SARS-CoV-2.

The human Betacoronavirus SARS-CoV-2 is a novel pathogen claiming millions of lives and causing a global pandemic that has disrupted international healthcare systems, economies, and communities. The virus is fast mutating and presenting more infectious but less lethal versions. Currently, some small-molecule therapeutics have received FDA emergency use authorization for the treatment of COVID-19, including Lagevrio (molnupiravir) and Paxlovid (nirmaltrevir/ritonavir), which target the RNA-dependent RNA polymerase and the 3CLpro main protease, respectively.

Computational Fluid Dynamics Simulation on Thermal Performance of Al/AlO/SWCNT Nanocoolants for Turning Operations.

The objective of this study is to numerically investigate the thermal performance of cutting fluids dispersed with nanoparticles for effective heat removal during turning operations. The simulations are performed using Ansys Fluent software, and the problem is modelled as a three-dimensional turbulent incompressible single-phase flow. The computational domain consists of a heated cutting tool and work piece, and nanocoolants are sprayed from a nozzle located above the machining zone.

Efficacy of Subcutaneous Closed Suction Drain in Reduction of Postoperative Surgical Site Infection.

 Surgical site infections (SSIs) are the infections of wound after an invasive operative approach. It remains to be a major morbidity for patients undergoing surgeries although there have been tremendous improvements in the surgical techniques. Different interventions to suppress the selective serotonin reuptake inhibitors have been proposed.

Clinical Spectrum of Neurological Manifestations in Pediatric COVID-19 Illness: A Case Series.

We describe a cohort of three patients with variable neurological presentations by SARS-COV-2 infection. It includes one case each of acute cerebellitis, acute encephalomyelitis and arterial ischemic stroke. To the best of our knowledge, we report the first pediatric case of acute cerebellitis due to SARS-CoV-2 infection.

Early Neurodevelopmental Outcome of Neonates with Gestation 35 Weeks or More with Serum Bilirubin in Exchange Range Without Encephalopathy: A Prospective Observational Study.

Objective: To describe early neurodevelopment outcomes of neonates with severe hyperbilirubinemia without acute bilirubin encephalopathy (ABE).

Methods: Neonates born at gestation ≥35 weeks, admitted to NICU with total serum bilirubin (TSB) in exchange range with no features of ABE, were followed up until the age of 6 months. Infants were assessed for impaired hearing and neurodevelopment at 3 months and 6 months of age.

Health insurance coverage and its impact on out-of-pocket expenditures at a public sector hospital in Kerala, India.

Background: Health insurance coverage ensures protection from catastrophic health-care expenditure, especially to the underprivileged sections of society. Health insurance schemes such as Ayushman Bharat are coming up in addition to the existing schemes such as Rashtriya Swasthya Bima Yojana in India. The objectives are to find the health insurance coverage and its impact on out-of-pocket (OOP) expenditure for public sector tertiary health-care hospitalization.

Comparison of postoperative analgesia and opioid requirement with thoracic epidural vs. continuous rectus sheath infusion in midline incision laparotomies under general anaesthesia - A prospective randomised controlled study.

Background And Aims: To assess and compare the effect of bilateral continuous rectus sheath infusion (CRSB) for postoperative analgesia with continuous thoracic epidural infusion (TEA) in patients undergoing midline incision laparotomies.

Methods: A prospective, randomised study involving sixty patients with Indian Society of Anesthesiologists (ASA) grade I to III, planned for elective laparotomy were enrolled for the study. Patients were randomly allocated into two groups.