Publications by authors named "Harish Palnitkar"
Background: Despite its success in the mechanical characterization of biological tissues, magnetic resonance elastography (MRE) uses ill-posed wave inversions to estimate tissue stiffness. 1-Norm has been recently introduced as a mathematical measure for the scattering of mechanical waves due to inhomogeneities based on an analysis of the delineated contours of wave displacement.
Purpose: To investigate 1-Norm as an MRE-based quantitative biomarker of mechanical inhomogeneities arising from microscopic structural tissue alterations caused by the freeze-thaw cycle (FTC) or Alzheimer's disease (AD).
Pulmonary diseases and injury lead to structural and functional changes in the lung parenchyma and airways, often resulting in measurable sound transmission changes on the chest wall surface. Additionally, noninvasive imaging of externally driven mechanical wave motion in the chest (e.g.
View Article and Find Full Text PDFArticle Synopsis
- Soft biological tissues like muscle and brain matter exhibit complex structure due to fibers, making them inhomogeneous and anisotropic, which complicates shear wave propagation analysis.
- The study introduces a new mathematical tool called the 1-Norm to evaluate when it is appropriate to treat these tissues as homogeneous through experiments with 3D printed phantoms and porcine muscle using Magnetic Resonance Elastography.
- Findings show that lower 1-Norm values correlate with reduced wave scattering in areas with fiber intersections, suggesting that under certain conditions, wave behavior can be simplified to that of a homogeneous medium, while significant scattering indicates the need to consider inhomogeneities.