Relevance of Troponin I Elevation among Individuals with Hypertensive Emergency.

Maheshwarappa HM, Rai AV. Relevance of Troponin I Elevation among Individuals with Hypertensive Emergency. Indian J Crit Care Med 2022;26(7):767-769.

A Rare Case of Primary Pyogenic Ventriculitis in a Patient with Community-acquired Meningitis.

Unlabelled: Pyogenic ventriculitis is defined as the inflammation of the ependymal lining of the cerebral ventricular system. It is characterized by the presence of suppurative fluid in the ventricles. It mostly affects neonates and children but rarely can be seen in adult population.

Story of an Abscess: A Case of Infection in an Immunocompetent Patient.

Unlabelled: is a very unusual cause of infection in immunocompetent patients. It is a rapidly growing microbe that rarely causes disseminated infection or native valve endocarditis. This organism exhibits intrinsic and acquired resistance to multiple antibiotics and hence becomes a major issue in planning treatment regimens.

Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria.

Background: Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of meropenem achieves fT > MIC > 40 on the first and third days of therapy in patients with severe sepsis or septic shock. We also simulated the performance of the EI with respect to other pharmacokinetic (PK) targets such as fT > 4 × MIC > 40, fT > MIC = 100, and fT > 4 × MIC = 100.