Microcrystalline cellulose and itaconic acid pH sensitive semi-interpenetrating network hydrogel for oral insulin delivery.

Diabetes mellitus is one of the important causes of death worldwide. Generally, a subcutaneous route is used for insulin administration, but has showen low patient compliance. Extensive research has been conducted to identify molecules capable of delivering insulin orally, for this hydrogel based on microcrystalline cellulose and itaconic acid have been produced and explored.

pH-sensitive semi-interpenetrating network of microcrystalline cellulose and methacrylic acid hydrogel for the oral delivery of insulin.

Insulin is commonly administered to diabetic patients subcutaneously and has shown poor patient compliance. Due to this, research has been carried out extensively to find molecules that could deliver insulin orally. In this context, a new type of pH-responsive hydrogel, composed of microcrystalline cellulose and methacrylic acid-based hydrogels, has been developed and studied for the oral delivery of insulin.