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Publications by authors named "Harish Grover"

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In vivo selection of rifamycin-resistant Clostridium difficile during rifaximin therapy.
Robert J Carman James H Boone Harish Grover Kimberly N Wickham Li Chen

Antimicrob Agents Chemother

November 2012

We report the selection of Clostridium difficile resistant to the rifamycin class of antibiotics in a patient within 32 h of receiving rifaximin for the treatment of recurrent C. difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB.

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Synopsis of recent research by authors named "Harish Grover"

  • - Harish Grover's research primarily focuses on the development of antibiotic resistance, specifically in relation to Clostridium difficile and rifamycin antibiotics.
  • - A notable study highlighted the rapid selection of rifamycin-resistant Clostridium difficile in a patient undergoing rifaximin therapy, indicating the potential for swift resistance development.
  • - The findings of this research underscore the implications of single nucleotide substitutions within the rpoB gene as a mechanism for resistance, raising concerns about the long-term efficacy of rifaximin in treating recurrent C. difficile infections.

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