Publications by authors named "Harish Chevva"

Despite the potential health benefits of curcumin, such as antioxidant, anticancer, anti-inflammatory, and antimicrobial properties, its usage is limited by poor bioavailability and low aqueous solubility. Nano-formulations of curcumin have gained a lot of attention due to their increased bioavailability, solubility, circulation times, targeted specificity, decreased biodegradation, better stability, and improved cellular uptake. The current study aimed to enhance the bioavailability of curcumin using carbon nanodots (CNDs) as loading vehicles to deliver curcumin due to their excellent biocompatibility, aqueous solubility, and photoluminescence properties.

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The growth mechanism of silver nanowires (AgNWs) in solution has been thoroughly investigated and it has been demonstrated that factors like oxidative etching and inclusion of Cl ions in the reaction system play critical roles in the formation of AgNWs. This research is the first to report the growth mechanism of AgNWs in the solid state on a chitosan polymer film with respect to factors such as oxidative etching, Cl ions and time. The AgNW synthetic method is a green process that involves aqueous solvents for film preparation and ambient conditions for AgNW growth.

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Carbon nanodots (CNDs) have shown good antioxidant capabilities by scavenging oxidant free radicals such as diphenyl-1-picrylhydrazyl radical (DPPH•) and reactive oxygen species. While some studies suggest that the antioxidation activities associate to the proton donor role of surface active groups like carboxyl groups (⁻COOH), it is unclear how exactly the extent of oxidant scavenging potential and its related mechanisms are influenced by functional groups on CNDs' surfaces. In this work, carboxyl and the amino functional groups on CNDs' surfaces are modified to investigate the individual influence of intermolecular interactions with DPPH• free radical by UV-Vis spectroscopy and electrochemistry.

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In this paper, we describe a novel method of silver nanowire (AgNW) synthesis. Silver nanoparticles (AgNPs) were synthesized under ambient conditions by a chitosan/chitin-based method. These crystalline AgNPs then served as seeds for the solid-state formation of AgNWs within a drop-cast chitosan/chitin thin film.

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Carbon nanodots (CNDs) have attracted great attention due to their superior solubility, biocompatibility, tunable photoluminescence, and opto-electronic properties. This work describes a new fluorescence-based spectroelectrochemistry approach to simultaneously study the photoluminescence and wavelength dependent photocurrent of microwave synthesized CNDs. The fluorescence of CNDs shows selective quenching upon a reversible redox couple, ferricyanide/ferrocyanide, reaction during cyclic voltammetry.

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Synopsis of recent research by authors named "Harish Chevva"

  • - Harish Chevva's recent research focuses on the analytical evaluation of leachable compounds, particularly in electronic nicotine delivery systems (ENDS), emphasizing the need for improving methods to assess data deficient compounds associated with these products.
  • - His work also explores innovative nanotechnology applications, such as using carbon nanodots for enhanced delivery systems of curcumin, addressing challenges related to bioavailability and promoting anticancer activities through improved formulations.
  • - Additionally, Chevva investigates the synthesis and growth mechanisms of silver nanowires on biodegradable polymer films, highlighting environmentally friendly processes that utilize chitosan while also examining the influence of functional groups on the antioxidant properties of nanodots.