Publications by authors named "Haris Car"
Article Synopsis
- The study examined antibiotic resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Europe, focusing on changes influenced by aging populations, migrations, and climate change over the last three years.
- Researchers compared hospital and community isolates to analyze resistance mechanisms, trends, and types of carbapenemases and plasmids, using methods like disk diffusion and PCR.
- Results showed high resistance rates to common antibiotics, with OXA-48 being the predominant carbapenemase found in the majority of isolates, indicating a similar trend to neighboring countries.
Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous surgical procedures coincide with resistance determinants of AmpC-producing Enterobacterales associated with bloodstream infections. Antibiotic resistance patterns and therapy outcome were also determined.
View Article and Find Full Text PDFResistance to carbapenems in has become a matter of the highest concern in the last decade. Recently, harboring multiple carbapenemases were detected in three hospital centers in Croatia and in the outpatient setting, posing a serious therapeutic challenge for clinicians. In this study, we analyzed eight and two complex isolates with multiple carbapenemases, with regard to antibiotic susceptibility, β-lactamase production and plasmid content.
View Article and Find Full Text PDFPhenotypic detection of metallo-β-lactamases (MBLs) in is a serious challenge to clinical microbiologists. MBLs are inhibited by metal chelators such as ethylenediaminetetraacetic acid) (EDTA). Production of MBLs cannot be recognized based on resistance phenotype.
View Article and Find Full Text PDFAim: The aim of the study was to determine in vitro synergy and postantibiotic effect of colistin alone and combined with meropenem or vancomycin against Enterobacteriaceae producing multiple carbapenemases; combinations of two metallo-β-lactamases (MBL) or MBL with OXA-48. Colistin-resistant strain positive for OXA-48 was also included in the study.
Methods: The antibiotic susceptibility was tested by broth microdilution method.