The effect of memory cue duration on performance in the directed forgetting task in healthy aging.

Although forgetting is usually considered a memory error, intentional forgetting can function as an adaptive mechanism. The current study examined the effect of increased processing time on directed forgetting in aging as a mechanism to compensate for age-related forgetting. Specifically, an item-method directed forgetting paradigm was used in conjunction with Remember/Know/New responding to examine the effect of cue duration (1, 3, 5 s) on directed forgetting and remembering in younger and older adults.

Examining the Neural Basis of Congruent and Incongruent Configural Contexts during Associative Retrieval.

Disrupting the configural context, or relative organization and orientation of paired stimuli, between encoding and retrieval negatively impacts memory. Using univariate and multivariate fMRI analyses, we examined the effect of retaining and manipulating the configural context on neural mechanisms supporting associative retrieval. Behavioral results showed participants had significantly higher hit rates for recollecting pairs in a contextually congruent, versus incongruent, configuration.

Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension.

Pulmonary arterial hypertension (PAH) is a progressive lethal disease with a known gender dimorphism. Female patients are more susceptible to PAH, whereas male patients have a lower survival rate. Initial pulmonary vascular damage plays an important role in PAH pathogenesis.