Leveraging generative neural networks for accurate, diverse, and robust nanoparticle design.

Tandem neural networks for inverse design can only make single predictions, which limits the diversity of predicted structures. Here, we use conditional variational autoencoder (cVAE) for the inverse design of core-shell nanoparticles. cVAE is a type of generative neural network that generates multiple valid solutions for the same input condition.

Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions.

This study aims to improve the biopharmaceutical, mechanical, and tableting properties of a poorly soluble drug, ibuprofen (IBP), by preparing amorphous solid dispersion (ASD) followed by a sustained-release tablet formulation. A suitable polymer to develop an ASD system was chosen by utilizing the apparent solubility of IBP in various polymer solutions. ASDs containing various ratios of IBP and selected polymer were prepared by the melt fusion (MF) method.

Growth, structural, thermal, and optical characteristics of L-asparagine monohydrate doped magnesium sulphate heptahydrate semiorganic crystals.

A novel semi-organic crystal has been grown using slow evaporation technique by doping organic compound L-asparagine monohydrate (CHNO·HO) with inorganic material Magnesium sulphate heptahydrate (MgSO·7HO). The crystallographic parameters like strain, dislocation density and crystallite size were calculated by powder X-ray diffraction method. Functional groups were identified and bond length, force constants were calculated from FT-IR spectroscopy.

Evaluation of chitosan-Ag/TiO nanocomposite for the enhancement of shelf life of chili and banana fruits.

Post-harvest losses of fruits and vegetables account for a large share of food waste in the world due to improper handling and packaging. By using the sol-gel method, Ag/TiO nanocomposite was prepared in this study from micro-sized commercial TiO powder and incorporated in a chitosan-cellulose matrix for the purpose of promising food packaging. The particle size and distribution of Ag nanoparticles (9.

Abundance, characteristics, and ecological risks of microplastics in the riverbed sediments around Dhaka city.

Microplastic (MP) pollution has become an escalating problem in Bangladesh due to its rapid urbanization, economic growth, and excessive use of plastics; however, data on MP pollution from fresh water resources in this country are limited. This study investigated microplastics pollution in riverbed sediments in the peripheral rivers of Dhaka, the capital of Bangladesh. Twenty-eight sediment samples were collected from the selected stations of the Buriganga, Turag, and Balu Rivers.

A QbD Approach to Design and to Optimize the Self-Emulsifying Resveratrol-Phospholipid Complex to Enhance Drug Bioavailability through Lymphatic Transport.

Objectives: Despite having profound therapeutic value, the clinical application of resveratrol is restrained due to its <1% bioavailability, arising from the extensive fast-pass effect along with enterohepatic recirculation. This study aimed to develop a self-emulsifying formulation capable of increasing the bioavailability of resveratrol via lymphatic transport. Methods: The resveratrol−phospholipid complex (RPC) was formed by the solvent evaporation method and characterized by FTIR, DSC, and XRD analyses.

Evaluation of a novel nanocrystalline hydroxyapatite powder and a solid hydroxyapatite/Chitosan-Gelatin bioceramic for scaffold preparation used as a bone substitute material.

Artificially fabricated hydroxyapatite (HAP) shows excellent biocompatibility with various kinds of cells and tissues which makes it an ideal candidate for a bone substitute material. In this study, hydroxyapatite nanoparticles have been prepared by using the wet chemical precipitation method using calcium nitrate tetra-hydrate [Ca(NO).4HO] and di-ammonium hydrogen phosphate [(NH) HPO] as precursors.

Toxicity Studies of Chitosan-Coated Cobalt Ferrite Nanocomplex for Its Application as MRI Contrast Dye.

Cobalt ferrite nanoparticle (CFN) has received attention in magnetic resonance imaging (MRI) as a promising contrast agent due to its higher saturation magnetization and magneto-crystalline anisotropy. However, the cytotoxicity of CFN has raised concern for its biomedical application as a diagnostic agent. The coating of CFN by a biocompatible polymer such as chitosan (CH) might lessen the biocompatibility concern.

Magnetic-field-induced phase separation via spinodal decomposition in epitaxial manganese ferrite thin films.

In this study, we report about the occurrence of phase separation through spinodal decomposition (SD) in spinel manganese ferrite (Mn ferrite) thin films grown by Dynamic Aurora pulsed laser deposition. The driving force behind this SD in Mn ferrite films is considered to be an ion-impingement-enhanced diffusion that is induced by the application of magnetic field during film growth. The phase separation to Mn-rich and Fe-rich phases in Mn ferrite films is confirmed from the Bragg's peak splitting and the appearance of the patterned checkerboard-like domain in the surface.