Structural atlas of human primary microRNAs generated by SHAPE-MaP.

MicroRNA (miRNA) maturation is critically dependent on structural features of primary transcripts (pri-miRNAs). However, the scarcity of determined pri-miRNA structures has limited our understanding of miRNA maturation. Here, we employed selective 2'-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP), a high-throughput RNA structure probing method, to unravel the secondary structures of 476 high-confidence human pri-miRNAs.

A Quenched Disorder in the Quantum-Critical Superconductor CeCoIn.

Emergent inhomogeneous electronic phases in metallic quantum systems are crucial for understanding high-T superconductivity and other novel quantum states. In particular, spin droplets introduced by nonmagnetic dopants in quantum-critical superconductors (QCSs) can lead to a novel magnetic state in superconducting phases. However, the role of disorders caused by nonmagnetic dopants in quantum-critical regimes and their precise relation with superconductivity remain unclear.

Evidence for charge delocalization crossover in the quantum critical superconductor CeRhIn.

The nature of charge degrees-of-freedom distinguishes scenarios for interpreting the character of a second order magnetic transition at zero temperature, that is, a magnetic quantum critical point (QCP). Heavy-fermion systems are prototypes of this paradigm, and in those, the relevant question is where, relative to a magnetic QCP, does the Kondo effect delocalize their f-electron degrees-of-freedom. Herein, we use pressure-dependent Hall measurements to identify a finite-temperature scale E that signals a crossover from f-localized to f-delocalized character.

Hybridization-Controlled Pseudogap State in the Quantum Critical Superconductor CeCoIn_{5}.

The origin of the partial suppression of the electronic density states in the enigmatic pseudogap behavior, which is at the core of understanding high-T_{c} superconductivity, has been hotly contested as either a hallmark of preformed Cooper pairs or an incipient order of competing interactions nearby. Here, we report the quasiparticle scattering spectroscopy of the quantum critical superconductor CeCoIn_{5}, where a pseudogap with energy Δ_{g} was manifested as a dip in the differential conductance (dI/dV) below the characteristic temperature of T_{g}. When subjected to external pressure, T_{g} and Δ_{g} gradually increase, following the trend of increase in quantum entangled hybridization between the Ce 4f moment and conduction electrons.

ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8.

The microprocessor complex cleaves the primary transcript of microRNA (pri-miRNA) to initiate miRNA maturation. Microprocessor is known to consist of RNase III DROSHA and dsRNA-binding DGCR8. Here, we identify Enhancer of Rudimentary Homolog (ERH) as a new component of Microprocessor.