Morpho-cultural, pathogenic, and genetic characterization of Indian isolates of causing charcoal rot in soybean.

, a devastating soil and seed-borne fungus causing charcoal rot in soybean, poses a significant challenge to soybean production and breeding programs across all major soybean-growing regions of India. Fifty-five isolates were collected from India's eight diverse soybean-growing agroecological regions. These isolates were examined for morpho-cultural, molecular, and pathogenic variability.

Assessment of genetic diversity in for yield, nutritional traits and ensiling quality.

The low sugar content of tropical range grasses makes them difficult to ensiling. This study identified sugar rich (>7 % on dry matter basis) accessions of (), which is adequate to initiate lactic acid production during ensiling. a prominent range grass of grasslands in India followed by Africa, Pakistan, China and Australia.

Domain-Specific Memory Impairments in Bipolar Mania: Insights from a Tertiary Care Hospital.

Background: Cognitive deficits in bipolar affective disorder (BPAD), particularly during manic episodes, are well-documented. However, research on domain-specific memory impairments in bipolar mania is limited, especially in the Indian subcontinent. This study aimed to assess memory impairments in individuals with bipolar disorder using the Postgraduate Institute Memory (PGI-Memory) scale and to highlight domain-specific deficits compared to healthy controls.

Repurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4.

In the present study, we aim to identify a potential drug candidate that targets the Monocarboxylate Transporter-4 (MCT-4) protein. Syrosingopine (SRY) is a well-established inhibitor of lactate transport through MCT-4. We screened 2,11,192 potential leads through ZINC database, which were atleast 50 % structurally similar with SYR.

Synthesis and screening of novel 2,4-bis substituted quinazolines as tubulin polymerization promoters and antiproliferative agents.

Twelve 2,4-bis-substituted quinazoline-based compounds were synthesized and screened for antiproliferative and tubulin polymerization enhancing potential. In the series, compound A4V-3 substituted with an imidazole ring displayed IC values of 4.25 μM, 2.

Idiopathic Scrotal Calcinosis (ISC): A Familial Case Series of Two Cases.

Idiopathic scrotal calcinosis (ISC) is a rare condition characterized by the development of multiple, asymptomatic, painless nodules on the scrotal skin. While typically considered idiopathic, its etiology remains unclear, with potential links to the dystrophic calcification of pre-existing lesions. We present a familial case series of father and son with ISC, highlighting the clinical presentation, surgical management, and importance of histopathological confirmation.

Assessment of the Efficacy of Subgingivally Delivered Liquorice Gel on Clinical Parameters and Prostaglandin E2 Levels in Chronic Periodontitis: A Clinico-Biochemical Study.

Background: Liquorice, also known as "mulaithi" in North India, has shown anti-inflammatory, antimicrobial, and anti-adherence effects that can prevent and treat various periodontal diseases.

Aim: This study aims to assess the efficacy of subgingivally delivered liquorice gel on clinical parameters and prostaglandin E2 (PGE2) levels in chronic periodontitis.

Materials And Methods: A split-mouth, single-blind, prospective, parallel, randomized controlled clinical trial was conducted.

Impact of Sodium, Potassium, and Calcium on the Child-Pugh and MELD Scores in Assessing the Severity of Liver Cirrhosis: A Two-Year Cross-Sectional Study.

Background and aim Patients with chronic liver disease are prone to experiencing electrolyte imbalances as a result of physiological changes caused by cirrhosis. These imbalances have a detrimental effect on prognosis, morbidity, and mortality. This study aimed to assess the serum concentrations of sodium, calcium, and potassium in patients with liver cirrhosis and determine their correlation with disease severity and prognosis.

Breaking the Silence: A Community-Based Cross-Sectional Study Exploring the Attitude Towards Premenstrual Syndrome Among Adults in Perambalur District of Tamil Nadu, India.

Background Menstruation is a natural process crucial for female reproductive health. Premenstrual syndrome (PMS) is characterized by physical and emotional symptoms occurring before menstruation. Social and cultural factors significantly influence menstrual attitudes and PMS perception.

Improvement in Gait Abnormality Following Minimally Invasive Posterior Sacroiliac Joint Fusion.

Background Sacroiliac joint (SIJ) dysfunction is a common cause of low back pain and associated gait disturbances that result from aberrant muscle activity and symmetry. This study evaluated the magnitude of improvement in gait characteristics in patients with chronic SIJ pain followed for six months after minimally invasive posterior SIJ fusion. Methods This was a single-arm, prospective, pilot study at two private practice orthopedic pain clinics.

Necrotic erythema nodosum leprosum - A case of severe lepromatous reaction in a multibacillary leprosy patient.

Necrotic erythema nodosum leprosum (ENL) is an uncommon and severe complication of multibacillary leprosy, characterized by intense systemic inflammation, ulcerative lesions, and significant morbidity. This case report describes a 32-year-old male presenting with recurrent type 2 lepra reactions and necrotic lesions exacerbated by inconsistent adherence to multidrug therapy (MDT). The patient's management involved MDT, corticosteroids, thalidomide, and hydroxychloroquine, which led to a substantial clinical improvement.

Convergent Agonist and Heat Activation of Nociceptor TRPM3.

Detecting noxious heat is vital for survival, triggering pain responses that protect against harm. The TRPM3 channel is a key nociceptor for sensing noxious heat and a promising therapeutic target for pain treatment and neurological disorders such as epilepsy. Here, we functionally and structurally characterized TRPM3 in response to diverse stimuli: the synthetic superagonist CIM0216 , the anticonvulsant antagonist primidone, and heat.

Oxidative Phosphorylation (OXPHOS) Promotes the Formation and Growth of Melanoma Lung and Brain Metastases.

Unlabelled: Melanoma mortality is driven by the formation and growth of distant metastases. Here, we interrogated the role of tumor oxidative phosphorylation (OXPHOS) in the formation of distant metastases in melanoma. OXPHOS was the most upregulated metabolic pathway in primary tumors that formed distant metastases in the RCAS-TVA mouse model of spontaneous lung and brain metastases, and in melanoma patients that developed brain or other distant metastases.

CD8 T cells mediate vaccination-induced lymphatic containment of latent infection following immunosuppression, while B cells are dispensable.

It is estimated that two billion people are latently infected with ( ), the causative agent of tuberculosis (TB). Latent infection (LTBI) can occur in multiple organs, including the lymphatics. The risk of LTBI reactivation increases in immunocompromised conditions, such as coinfection with human immunodeficiency virus (HIV), and during treatment of autoimmune diseases and organ transplantation.

Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells.

To identify new therapeutic targets that limit glioblastoma (GBM) invasion, we applied druggable-genome CRISPR screens to patient-derived GBM cells in micro-dissectible biomimetic 3D hydrogel platforms that permit separation and independent analysis of core vs. invasive fractions. We identified 12 targets whose suppression limited invasion, of which ACP1 (LMW-PTP) and Aurora Kinase B (AURKB) were validated in neurosphere assays.

Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium.

Stromal fibroblasts regulate critical signaling gradients along the intestinal crypt-villus axis and provide a niche that supports adjacent epithelial stem cells. Here we report that -expressing fibroblasts secrete ligands that promote a regenerative-like state in the intestinal mucosa during early WNT-mediated tumorigenesis. Using a mouse model of WNT-driven oncogenesis and single-cell RNA sequencing (RNA-seq) of mesenchyme cell populations, we revealed a dynamic reprogramming of Pdgfra fibroblasts that facilitates WNT-mediated tissue transformation.

Multifaceted Actions of Neurosteroids.

Background And Purpose: Neurosteroids modulate neuronal function and are promising therapeutic agents for neuropsychiatric disorders. Neurosteroid analogues are approved for treating postpartum depression and are of interest in other disorders. GABA-A receptors are well characterized targets of natural neurosteroids, but other biological pathways are likely relevant to therapeutic mechanisms and/or to off-target effects.

Clinico-Epidemiological Study of Morphological Patterns of Allergic Contact Dermatitis due to Lac Bangles in Females of Hadoti Region.

Background: India is a country with diverse religious and cultural practices instigating skin diseases which may be missed due to lack of awareness. Contact dermatitis (CD) to lac is not uncommon yet an underreported entity.

Objectives: To study clinical patterns of allergic CD due to lac bangles and to assess common contact allergens.

Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy.

Introduction: Studies have demonstrated that injectable GnRH receptor agonists further suppress cancer progression when paired with radiotherapy (RT) in patients with intermediate- to high-risk prostate adenocarcinoma. Relugolix is a newly available oral GnRH receptor antagonist that achieves swift and profound castration (total testosterone <20 ng/dl) at high rates, which may shape patients' health-related quality of life. The main objective of this prospective study was to explore the effects of neoadjuvant relugolix on health-related quality of life in prostate cancer patients immediately prior to stereotactic body radiation therapy (SBRT).

GAN inversion and shifting: recommending product modifications to sellers for better user preference.

In efforts to better accommodate users, numerous researchers have endeavored to model customer behavior, seeking to comprehend how they interact with diverse items within online platforms. This exploration has given rise to recommendation systems, which utilize customer similarity with other customers or customer-item interactions to suggest new items based on the existing item catalog. Since these systems primarily focus on enhancing customer experiences, they overlook providing insights to sellers that could help refine the aesthetics of their items and increase their customer coverage.

Nanocellulose-Supported Dual S-Scheme SnWO/CuO/AgWO Heterojunction for Enhanced Photodegradation of Amoxicillin.

A dual S-scheme nanocellulose-based SnWO/CuO/AgWO (NC-SCA) heterojunction photocatalyst was synthesized via ultrasonication followed by a hydrothermal method for the efficient photodegradation of amoxicillin (AMX). Under UV-vis light irradiation, the NC-SCA photocatalyst exhibited an impressive 97.40% AMX degradation within 30 min, attributed to its improved optical absorption and superior charge migration.

Dual Targeting of Prostate-Specific Membrane Antigen and Fibroblast Activation Protein: Bridging Prostate Cancer Theranostics with Precision.

Targeting Prostate Specific Membrane Antigen (PSMA) has proven highly useful and beneficial for prostate cancer (PCa) theranostics. However, patients with advanced metastatic castration-resistant prostate cancer (mCRPC) lack optimal PSMA expression resulting in poor specificity. To address this limitation, combination targeting is gaining popularity by synergistically boosting the theranostic efficacy.