Influence of Ferrule Design and Occlusal Thickness on the Fracture Resistance and Failure Patterns of Zirconia Endocrowns.

Background And Objective: Zirconia endocrowns are a popular restorative option due to their fracture resistance and aesthetic appeal, but the influence of different preparation designs on their performance remains underexplored. This study evaluated the effects of preparation design and the occlusal thickness on the fracture strength and failure modes of zirconia endocrowns in endodontically treated teeth.

Materials And Methods: Thirty-two extracted human mandibular first molars were endodontically treated and divided into four groups (n = 8), based on margin design and occlusal thickness: Group A: 2 mm butt joint with 3 mm occlusal thickness, Group B: 1 mm butt joint with 4 mm occlusal thickness, Group C: 2 mm ferrule with 3 mm occlusal thickness, and Group D: 1 mm ferrule with 4 mm occlusal thickness.

Dry Needling and Its Application in Dentistry: A Review.

Dry needling is a technique increasingly being used across various medical and therapeutic fields, including dentistry. It involves the insertion of fine needles into specific points in muscles or tissues to alleviate pain and promote healing. This paper explores the application of dry needling within the field of dentistry, outlining its efficacy in treating conditions such as temporomandibular joint disorders (TMD), myofascial pain, and other musculoskeletal issues related to oral health.

Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis.

Purpose: We describe an unusual case of a rapidly progressive pilomatricoma along the left brow, which was initially misdiagnosed and treated as preseptal cellulitis. Although rare, pilomatricomas and other adnexal tumors should be considered in the differential diagnosis of a growing mass near the brow.

Case Presentation: A 29-year-old male presented to the emergency department with a progressively enlarging left brow lesion, initially noted 3 weeks prior.

Cortical lesions and focal white matter injury are associated with attentional performance in chronic traumatic brain injury.

Cognitive impairment, often due to attentional deficits, is a primary driver of disability after traumatic brain injury. It remains unclear whether attentional deficits are caused by injury to specific brain structures or the total burden of injury. In this cross-sectional, multicentre cohort study, we tested whether the association between brain injury and attentional performance varies by neuroanatomic location.

Frequency of trigeminal neurovascular contacts identified on 3D-fast imaging employing steady-state acquisition magnetic resonance imaging in asymptomatic adults.

Background: Neurovascular conflict is considered one of the main causes of Trigeminal neuralgia, and 3D fast imaging employing steady-state acquisition magnetic resonance imaging (MRI) is the diagnostic imaging of choice. However, no tool is available to confirm imaging findings as the primary cause of trigeminal neuralgia because neurovascular contact is frequently found in asymptomatic individuals, according to some literature, although very little data is available till now. Therefore, we aim to determine the frequency of trigeminal neurovascular contact, involved nerve segment, culprit vessel, and characteristics of contacts in asymptomatic individuals.

Cresp: transforming the landscape of chemotherapy-induced anemia - a comprehensive retrospective real-world analysis in 523 Indian patients.

Introduction: Anemia, a frequently encountered issue among cancer patients undergoing chemotherapy, is regrettably underappreciated despite its prevalence and profound impact on their well-being. Chemotherapy-induced anemia (CIA) diminishes the quality of life, causing fatigue, breathlessness, and a decline in the performance status. However, correcting anemia can lead to notable improvements in these parameters.

Comparative Study of Fluence Distribution and Point Dose Using Arc-check and Delta Phantoms.

The study aims to assess the fluence distribution and point dosage between two phantoms for patient-specific quality assurance on the Tomotherapy system. This was a retrospective study conducted on 15 patients who had radiation using the Helical Tomotherapy Machine (Radixact, Accuray Inc.).

Ensemble Learning for Three-dimensional Medical Image Segmentation of Organ at Risk in Brachytherapy Using Double U-Net, Bi-directional ConvLSTM U-Net, and Transformer Network.

Aim: This article presents a novel approach to automate the segmentation of organ at risk (OAR) for high-dose-rate brachytherapy patients using three deep learning models combined with ensemble learning techniques. It aims to improve the accuracy and efficiency of segmentation.

Materials And Methods: The dataset comprised computed tomography (CT) scans of 60 patients obtained from our own institutional image bank and 10 patients from the other institute, all in Digital Imaging and Communications in Medicine format.

Banding Down the Hurdles: Evaluating Endoscopic Variceal Ligation for Rectal Varices.

Portal hypertension can lead to the formation of rectal varices. Rectal varices are a common manifestation of portal hypertension but tend to bleed less frequently than esophageal or gastric varices. It has been observed that rectal varices can result in significant lower gastrointestinal (GI) bleeding and pose unique therapeutic challenges.

Conditional diffusion-generated super-resolution for myocardial perfusion MRI.

Introduction: Myocardial perfusion MRI is important for diagnosing coronary artery disease, but current clinical methods face challenges in balancing spatial resolution, temporal resolution, and slice coverage. Achieving broader slice coverage and higher temporal resolution is essential for accurately detecting abnormalities across different slice locations but remains difficult due to constraints in acquisition speed and heart rate variability. While techniques like parallel imaging and compressed sensing have significantly advanced perfusion imaging, they still suffer from noise amplification, residual artifacts, and potential temporal blurring due to the rapid transit of dynamic contrast vs.

Synthetic strategies and medicinal chemistry perspectives of dual acting carbonic anhydrase modulators with monoamine oxidase and cholinesterase inhibitors.

Multi-target drug design (MTDD) represents the paradigm shift in pharmaceutical research, moving beyond the conventional one-drug-one-target approach to address the complexity of multifactorial diseases. This strategy aims to develop single therapeutic candidates that can simultaneously modulate multiple biological targets, offering more comprehensive disease management and reducing the likelihood of drug resistance. In this article, we highlighted the design, synthesis, and structure-activity relationships (SARs) of various dual acting inhibitors involved in treatment of neurodegenerative diseases.

A perspective on small molecules targeting the renin-angiotensin-aldosterone system and their utility in cardiovascular diseases: exploring the structural insights for rational drug discovery and development.

Renin-angiotensin-aldosterone system (RAAS) is crucial in cardiovascular homeostasis. Any disruption in this homeostasis often leads to numerous cardiovascular diseases (CVDs) and non-cardiovascular diseases. Small molecules that show ability toward mechanically modulating RAAS components have been developed to address this problem, thus providing opportunities for innovative drug discovery and development.

Extreme Temperature Events in Kazakhstan and Their Impacts on Public Health and Energy Demand.

Extreme temperature events such as heatwaves are becoming increasingly severe and frequent because of climate change, posing significant challenges to public health and energy infrastructure. This study explores the impacts of extreme temperature events leading to heat-/cold waves on public health and energy consumption in Kazakhstan from 1959 to 2021. The most striking trends in heatwave-related indices emerge in the western and southwestern regions.

Acute Myelomonocytic Leukemia: A Rare Cause of Painless Jaundice.

Acute myelomonocytic leukemia (AMML) is a rare and aggressive subtype of acute myeloid leukemia with varying clinical manifestations. Although hepatic involvement in AMML is commonly seen, cholestatic hepatitis as a primary manifestation of the disease is very rare. In the present case, our elderly patient presented with predominant signs of cholestasis, including jaundice, nausea, and vomiting.

Genetic impact of copy number variations on congenital heart defects: Current insights and future directions.

Congenital heart defects (CHDs) are the most prevalent congenital abnormalities, and they are commonly associated with genetic alterations, namely copy number variants. CNVs, which are duplications or deletions of DNA sequences, can disrupt gene regulation, impact dosage-sensitive genes, and cause loss-of-function mutations, all of which can interfere with heart development. CNVs cause genomic instability by changing essential genes, which plays an important role in the pathophysiology of CHDs.

SDN TCP-SYN Dataset: A dataset for TCP-SYN flood DDoS attack detection in software-defined networks.

The TCP-SYNC SDN dataset, a collection of labelled network traffic data for investigating DDoS attack detection in Software-Defined Networking (SDN) environments. The dataset includes flow-level metrics from both normal and malicious traffic, particularly TCP-SYN flood attacks. Generated in a controlled testbed using advanced simulation tools Mininet(v2.

Roundtable: Global Histories of Technology in Worlds of Environmental Change.

In the face of diverse and uneven environmental crises across the globe, ongoing efforts to "globalize" the history of technology field may be considered urgent. In doing so, however, we risk uncritically exporting the norms and practices of a predominantly Western-centric field-an arguably colonial act. This roundtable explores four areas of contention: how to conceptualize "the global"; why, how and with whom to study "history" amid threatened "futures"; how to articulate and delineate the field's subject matter ("technology"); and how researchers can collaborate equitably within and across diverse sites around the globe.

Serial Lactate in Clinical Medicine - A Narrative Review.

Background: Blood lactate is commonly used in clinical medicine as a diagnostic, therapeutic and prognostic guide. Lactate's growing importance in many disciplines of clinical medicine and academic enquiry is underscored by the tenfold increase in publications over the past 10 years. Lactate monitoring is presently shifting from single to serial measurements, offering a means of assessing response to therapy and to guide treatment decisions.

MnO Tetrahedral with Carbonyldiimidazole Nanoflower Deposition on Laser-Scribed Graphene for Selective Bio-Capture.

Dengue fever, a mosquito-borne viral infection, poses a significant global health challenge, particularly in tropical and subtropical regions. The absence of non-effective vaccines and specific treatments underscores the need for advanced diagnostic tools for early detection and management. This study presents a novel biosensor for detecting dengue virus type 4 (DENV-4) by combining carbonyldiimidazole nanoflower (CDI-NF) with MnO on laser-scribed graphene (LSG).

Bayesian network modeling of statistical dependency within cognitive domains and clinical dementia severity ratings for Western and Indian cohorts.

BackgroundDementia is studied rigorously in the current times, to assess the potential factors that contribute towards its progression, such as demographic factors, geographical background as well as to understand its impact on essential life skills. Alzheimer's disease, the most common form of dementia, is a major focus due to its prevalence and lack of curative treatments.ObjectiveWe aim to study dementia progression across two geographically distinct populations, by analyzing Clinical Dementia Rating (CDR) scores and its domain-specific components, which reflect the decline in essential life skills.

Tunable Bi-directional Broadband Self-Powered Photoresponse in a 0D C/2-D SnS Nanoflower Heterostructure.

Realizing bidirectional photodetection is essential for developing next-generation artificial neuromorphic systems, visual information processing, and future optoelectronic logic gates. Photodetectors are promising visible light communication systems due to their energy efficiency and cost-effectiveness. Color shift keying is frequently used in visible light communication to meet non-negative light intensity modulation demands.

Electrochemical Scanning Microwave Microscopy Reveals Ion Intercalation Dynamics and Maps Active Sites in 2D Catalyst.

The accelerated demand for electrochemical energy storage urges the need for new, sustainable, and lightweight materials able to store high energy densities rapidly and efficiently. Development of these functional materials requires specialized techniques that can provide a close insight into the electrochemical properties at the nanoscale. For this reason, the electrochemical scanning microwave microscopy (EC-SMM) enabling local measurement of electrochemical properties with nanometer spatial resolution and sensitivity down to atto-Ampere electrochemical currents is introduced.

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline.

The poor survival of ovarian cancer patients is linked to their high likelihood of relapse. In spite of full apparent macroscopic clearance, tumor recurrences arise from cells that are resistant to primary chemotherapy in the form of minimal residual disease (MRD). MRD exhibits distinct molecular drivers from bulk cancer and therefore necessitates alternative therapeutic strategies.

Exploring the Relationship Between Smartphone GPS Patterns and Quality of Life in Patients With Advanced Cancer and Their Family Caregivers: Longitudinal Study.

Background: Patients with advanced cancer and their family caregivers often experience poor quality of life (QOL). Self-report measures are commonly used to quantify QOL of family caregivers but may have limitations such as recall bias and social desirability bias. Variables derived from passively obtained smartphone GPS data are a novel approach to measuring QOL that may overcome these limitations and enable detection of early signs of mental and physical health (PH) deterioration.