Publications by authors named "Hari Prasad Ranganathan"
Solid lipid nanoparticles of diethylcarbamazine citrate for enhanced delivery to the lymphatics: in vitro and in vivo evaluation.
Expert Opin Drug Deliv
September 2014
Article Synopsis
- The main goal of the research is to effectively deliver diethylcarbamazine citrate (DEC) to the lymphatic system while improving its retention time.
- Solid lipid nanoparticles (SLNs) were created using various excipients and evaluated for their characteristics, such as size and drug release efficiency.
- Results showed that SLNs can enhance drug delivery to the lymphatics, achieving a maximum entrapment efficiency of 68.63% and a complete drug release in about 150 minutes.
Antibiotics in South Indian coastal sea and farmed prawns (Penaeus monodon).
Food Addit Contam Part B Surveill
December 2014
Sulphonamides and chloramphenicol antibiotics were analysed by using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in sea and farmed prawn (Penaeus monodon) samples obtained from the coastal region of southern India during 2011-2012. Average recoveries were 77-99% and precision was between 1% and 8%. The results revealed that in sea prawn samples neither of the two antibiotics was detected, but in farmed samples from coastal Andhra Pradesh some sulphonamides were detected in a concentration range greater than the maximum residual limit as set by Council Directive 2377/90 EC.
View Article and Find Full Text PDFMicrowave-assisted derivatisation and LC-MS/MS determination of nitrofuran metabolites in farm-raised prawns (Penaeus monodon).
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
May 2014
A new microwave-assisted derivatisation and LC-MS/MS method has been developed for the analysis of nitrofuran metabolites - 3-amino-5-morpholino-methyl-1,3-oxa-zolidinone (AMOZ), 3-amino-2-oxazolidinone (AOZ), 1-aminohydantoin (AHD) and semicarbazide (SEM) - in farm-raised prawns (Penaeus monodon) from the coastal regions of South India. Analysis was carried out by reverse-phase column (Phenomenex Luna C18) with gradient elution using mobile phase A (0.02% acetic acid in water) and mobile phase B (0.
View Article and Find Full Text PDF