Sevenfold variation in global feeding capacity depends on diets, land use and nitrogen management.

Harvested food carries a fraction of the nitrogen applied through fertilization; the remainder is typically lost into the environment, impairing planetary sustainability. Using a global agriculture model that integrates key drivers of food production and nitrogen cycling, we simulated upper bounds to global feeding capacity-and associated nitrogen pollution-as a function of nitrogen limitation under organic and industrial fertilization regimes. We found that the current agricultural area could feed ~8-20 billion people under unconstrained industrial fertilization and ca.

Cardiovascular events in perimembranous ventricular septal defect with left ventricular volume overload: a French prospective cohort study (FRANCISCO).

Unlabelled: The long-term prospective multi-centre nationwide (French) observational study FRANCISCO will provide new information on perimembranous ventricular septal defect with left ventricular overload but no pulmonary hypertension in children older than 1 year. Outcomes will be compared according to treatment strategy (watchful waiting, surgical closure, or percutaneous closure) and anatomic features of the defect. The results are expected to provide additional guidance about the optimal treatment of this specific population, which is unclear at present.

[A furoncular ankle cellulitis in a teenager with a difference: Dermatobia hominis].

We report a case of botfly myiasis presenting as an ankle cellulitis in a teenager returning from Guyana. Main clinical features and therapeutic approaches are described.

[Hurler syndrome. Early diagnosis and successful enzyme replacement therapy: a new therapeutic approach. Case report].

Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder due to alpha-L-iduronidase deficiency. Its severe prognosis has been significantly improved by enzyme replacement therapy using recombinant human alpha-L-iduronidase (laronidase). We report the case of a boy who was diagnosed at 19 months of age with Hurler's disease, the most severe form of MPS I, and received thereafter a treatment by laronidase, resulting in clinical and biological improvement.

[Macrolides, Pseudomonas aeruginosa and cystic fibrosis].

Long-term low dose azithromycin treatment in cystic fibrosis patients with chronic Pseudomonas aeruginosa infection is safe and reduces the decline in lung function, the number of acute exacerbations and improves nutritional status; underlying efficacy mechanisms are multiple and synergistic.

[Varicella, acute postinfectious arteriopathy and cerebral arterial thrombosis in childhood: a unique clinical and etiologic framework to be fully acknowledged].

Acute arteriopathies are the etiological factor of 25% of all the cerebral arterial thrombosis cases in childhood; they give way to ischemic strokes which have specific clinical and radiological features; varicella is the etiologic factor in 60% of the cases; favorable outcome is the rule; physiopathology and treatment remain under discussion.