Publications by authors named "Harald Pruess"
Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies.
Neurol Neuroimmunol Neuroinflamm
January 2024
Article Synopsis
- Neurodegeneration is a significant factor in neurologic disorders linked to GAD65 antibodies, and this study explores neuroaxonal damage's relationship with disease duration and clinical symptoms.
- In a study involving 50 patients, serum neurofilament light chain (sNfL) levels were measured and correlated with disease progression and clinical presentations, using MRI to assess brain structure changes.
- The findings show elevated sNfL levels early in the disease, especially in patients with cerebellar ataxia and limbic encephalitis, alongside atrophy in specific brain regions, highlighting the importance of early intervention in these conditions.
Article Synopsis
- High levels of antibodies against glutamic acid decarboxylase (GAD-abs) are linked to various autoimmune neurological syndromes, while the significance of low serum levels is still debated.
- A study analyzed data from 101 patients suspected of having GAD-ab-associated neurological issues, revealing that most presented with conditions like epilepsy and cerebellar ataxia but had mixed outcomes with immunotherapy.
- The research found that low GAD-ab serum levels didn't significantly affect clinical characteristics or outcomes, suggesting that detecting unmatched oligoclonal bands in the cerebrospinal fluid may be more important than GAD-ab levels.
Article Synopsis
- The study aimed to compare the densities of corneal subbasal nerves and immune dendritiform cells between standard in vivo confocal microscopy (IVCM) images and wide-field mapped composite images.
- A total of 110 eyes from 58 patients were analyzed, and the findings showed no significant differences in nerve and DC densities between the two imaging methods.
- The results suggest that standard IVCM images are effective for measuring cellular structures in the cornea and can be reliably used in clinical research.
Animal models of neurodegenerative disease are excellent tools for studying pathogenesis and therapies including cellular transplantation. In this chapter, we describe different models of Huntington's disease and Parkinson's disease, stereotactic surgery (used in creation of lesion models and transplantation) and finally transplantation studies in these models.
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