variant may affect the response to type 2 biologics in patients with severe asthma.

Background: Asthma is a heterogeneous disease with variable response to treatment. Genetic backgrounds are involved in the severity of type 2 asthma, but their effects on responses to biologics remain unknown. This study aimed to clarify the role of genetic factors in response to biologics in patients with severe asthma.

Honeycomb-Shaped Collagen Aerogels Formed Using a Multichannel Hydrogel as the Template.

This study introduces a novel method for fabricating multicavity, honeycomb-shaped collagen aerogels characterized by continuous pores. We have taken a unique approach to lyophilizing collagen hydrogels, which are UV-irradiated collagen solutions gelatinized in a carbonate buffer solution. The focus of this study was to investigate the effect of UV irradiation times on collagen solutions on collagen hydrogels and aerogels.

The Validity of Radiographic Measurements Compared to 3D-surface Model-Based Measurements in Shoulders with Reverse Total Shoulder Arthroplasty.

Background: Postoperative assessment following reverse total shoulder arthroplasty (rTSA) typically involves plain radiographs to evaluate implant positioning parameters, such as humeral distalization and lateralization along with medialization and distalization of the center of rotation (COR). However, the precision of these radiographic measurements remains unclear. This study aimed to validate the accuracy of radiographic two-dimensional (2D) measurements compared to three-dimensional (3D) surface model-based measurements derived from CT data for evaluating postoperative parameters in rTSA.

Roles of osteoclasts in pathological conditions.

Bone is a unique organ crucial for locomotion, mineral metabolism, and hematopoiesis. It maintains homeostasis through a balance between bone formation by osteoblasts and bone resorption by osteoclasts, which is regulated by the basic multicellular unit (BMU). Abnormal bone metabolism arises from an imbalance in the BMU.

pH-Responsive Collagen Hydrogels Prepared by UV Irradiation in the Presence of Riboflavin.

This study reveals the pH-responsive behavior of collagen hydrogels prepared using ultraviolet (UV) irradiation with riboflavin as a photosensitizer. By varying the UV exposure time, we modulated the crosslinking density, thereby influencing the mechanical properties and pH responsiveness. Rheological analysis confirmed successful network formation, whereas swelling studies revealed significant pH-dependent behavior, with maximum swelling at a pH of four and minimal swelling above a pH of six, demonstrating partial reversibility over multiple pH cycles.

Greater distance from the glenosphere center to the acromion reduces risk of acromial impingement in semi-inlay reverse shoulder arthroplasty.

Background: Recently, the issue of subacromial notching, caused by acromial impingement has been reported. The purpose of this study was to assess the impact of differences in the distance between the glenosphere center and the greater tuberosity (DGT) and the distance between the glenosphere center and the acromion (DA) on the closest distance between the greater tuberosity and the acromion during active abduction in shoulders with reverse total shoulder arthroplasty (RSA).

Methods: Eleven shoulders with semiinlay RSA were analyzed.

CpG Methylation of Receptor Activator NF-κB (RANK) Gene Promoter Region Delineates Senescence-Related Decrease of RANK Gene Expression.

While the rapid decrease in estrogen is well known as the main cause of postmenopausal osteoporosis in women, the precise pathogenesis of senile osteoporosis in the elderly regardless of gender is largely unknown. The age-related epigenetic regulation of receptor activator NF-κB (RANK) gene expression was investigated with the use of a high-passaged mouse osteoclast progenitor cell line, RAW264.7, as an model of aging.

Occurrence and Characteristics of Fruiting Bodies on Living Trees in Japan.

is a globally distributed wood decay fungus that causes heartwood decay in several tree species. We investigated the occurrence of fruiting bodies in Japan for two years and six months to characterize their biology. The fruiting bodies matured in autumn and occurred on living , , , and trees, as well as on dead trees and soil.

Charge-Enhanced Reactivity of Esters by a Cationic Substituent.

In this study, the high electrophilicity of carbonyl carbons attached to cationic heterocycles was observed. Triazolium-substituted esters underwent catalyst-free amidation with aliphatic amines at -50 °C and reduction with NaBH at -100 °C. The origin and generality of the high reactivity of these esters were systematically investigated.

Reduced chemokine C-C motif ligand 1 expression may negatively regulate colorectal cancer progression at liver metastatic sites.

Colorectal cancer (CRC) liver metastasis, albeit a stage-IV disease, is completely curable by surgical resection in selected patients. In addressing the molecular basics of this phenomenon, differentially expressed genes at primary and liver metastatic sites were screened by RNA sequencing with the use of paraffin-embedded surgical specimens. Chemokine C-C motif ligand 1 (CCL1), a chemotactic factor for a ligand of the chemokine C-C motif receptor 8 (CCR8), was isolated as one of the differentially expressed genes.

Additive-Free Method for Enhancing the Volume Phase Transition Rate in Light-Responsive Hydrogels: A Study of Micro-Nano Bubble Water on PNIPAM-co-AAc Hydrogels.

Light-responsive hydrogels containing light-thermal convertible pigments have received interest for their possible applications in light-responsive shutters, valves, drug delivery systems, etc. However, their utility is limited by the slow response time. In this study, we investigated the use of micro-nano bubble water as a preparation solvent to accelerate the volume phase transition kinetics of poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-co-AAc) hydrogels.

Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms.

Background: Obstructive sleep apnea (OSA) is one of the major co-morbidities and aggravating factors of asthma. In OSA-complicated asthma, obesity, visceral fat, and systemic inflammation are associated with its severity, but the role of bronchial hyperresponsiveness (BHR) is unclear. We investigated the involvement of BHR and mediastinal fat width, as a measure of visceral fat, with OSA severity in patients with OSA and asthma-like symptoms.

Clear and simple detection of asbestos stained with two dyes for building materials collected from disaster and demolition sites using a stereomicroscope.

Whenever houses are demolished or disasters occur, large quantities of building materials are discharged, which may contain asbestos. To prevent the damage caused by asbestos exposure, a rapid asbestos presence confirmation method is required at demolition sites or temporary disaster storage sites. It is difficult to confirm the presence of asbestos in waste building materials by simple observation.

Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression.

The liver is known to possess remarkable regenerative potential, but persistent inflammation or severe acute injury can lead to liver fibrosis and incomplete regeneration, ultimately resulting in liver failure. Recent studies have shown that the axis of two types of CXCL12 receptors, CXCR4 and CXCR7, plays a crucial role in liver fibrosis and regeneration. The present study aimed to investigate the regulatory factors involved in CXCR4 expression in injured liver.

Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes.

Hollow collagen gels are promising materials for drug/cell delivery systems to promote tissue regeneration because they may be able to function as carriers for these types of loads. Controlling the cavity size and swelling suppression is essential to expand the applications and improve the usability of such gel-like systems. We investigated the effects of UV-treated collagen solutions as a pre-gel aqueous mixture on the formation and properties of the hollow collagen gels in terms of their preparation range limits, morphology, and swelling ratio.

Macroscopic Pattern Formation of Alginate Gels in a Two-Dimensional System.

Macroscopic spatial patterns were formed in calcium alginate gels when a drop of a calcium nitrate solution was placed on the center of a sodium alginate solution on a petri dish. These patterns have been classified into two groups. One is multi-concentric rings consisting of alternating cloudy and transparent areas observed around the center of petri dishes.

One-Pot Preparation of Collagen Tubes Using Diffusing Gelation.

One-pot gelation in capillary glass tubes with carbonate-based buffer solution allows the formation of hollow collagen gels (collagen tubes) with an outer diameter of 1 mm or less. The preparation conditions of collagen concentration, buffer concentration, and capillary diameter impacted the ratio and size of the hollow gel and allowed for morphological control of the cavity. The morphology of the hollows suggests that their vacancies are the result of macroscopic phase separation and pinning due to gelation.

Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage.

Pericytes are pluripotent cells that enclose the endothelium of small blood vessels in the whole body. These cells are thought to play a limited role in vascular development and blood pressure regulation; however, current evidence from numerous studies suggests several significant biologic aspects of pericytes in animals. One viewpoint is that pericytes are also known as potential cellular origin of multiple soft tissue tumors.

Fluoride-Mediated Nucleophilic Aromatic Amination of Chloro-1-1,2,3-triazolium Salts.

We report a fluoride-mediated nucleophilic aromatic amination of chloro-1-1,2,3-triazolium salts with aliphatic amines. The reaction proceeded under mild reaction conditions to provide amino-1,2,3-triazolium salts with various functional groups, which can be utilized for further transformations. Moreover, it was found that an amino-1,2,3-triazolium salt was transformed via deprotonation into the N-heterocyclic imine (NHI), which exhibited the excellent catalytic activity for the cyanosilylation of acetophenone with trimethylsilyl cyanide.

Study of Frontal and Temporal Hairline Patterns in Japanese Subjects.

Unlabelled: The shape of the hairline is very important in a person's identity and in determining the impression they make. Reports on the morphology of a normal hairline are still scarce. Differences in the shape of male and female hairlines in Japanese subjects are discussed in this study.

The Menstrual Cycle Alters Resting-State Cortical Activity: A Magnetoencephalography Study.

Resting-state neural oscillations are used as biomarkers for functional diseases such as dementia, epilepsy, and stroke. However, accurate interpretation of clinical outcomes requires the identification and minimisation of potential confounding factors. While several studies have indicated that the menstrual cycle also alters brain activity, most of these studies were based on visual inspection rather than objective quantitative measures.