Publications by authors named "Haozhong Hou"
Article Synopsis
- Upper tract urothelial carcinoma (UTUC) is a rare cancer with poor prognosis, and this study explores the effects of adjuvant treatment using tislelizumab, with or without chemotherapy, on patients after surgery.
- A retrospective analysis of 63 high-risk UTUC patients showed that most responded positively, with 78% achieving stable disease after treatment, and the two-year survival rates were favorable.
- However, 92% of patients experienced some treatment-related side effects, indicating the treatment's manageable safety profile despite the presence of serious adverse reactions in some cases.
Most mammals tolerate exposure to hypobaric hypoxia poorly as it may affect multiple regulatory mechanisms and inhibit cell proliferation, promote apoptosis, limit tissue vascularization, and disrupt the acid-base equilibrium. Here, we quantified the functional state of germ cell development and demonstrated the interaction between the germ and somatic cells via single-cell RNA sequencing (scRNA-seq). The present study elucidated the regulatory effects of hypobaric hypoxia exposure on germ cell formation and sperm differentiation by applying enrichment analysis to genomic regions.
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