The emerging role of Piezo1 in the musculoskeletal system and disease.

Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating mechanical stimuli into biological signaling. Its involvement extends beyond physiological and pathological processes such as lymphatic vessel development, axon growth, vascular development, immunoregulation, and blood pressure regulation. The musculoskeletal system, responsible for structural support, movement, and homeostasis, has recently attracted attention regarding the significance of Piezo1.

Canonical pathways for validating steroid-associated osteonecrosis in mice.

The present study aimed to establish and evaluate a preclinical model of steroid-associated osteonecrosis (SAON) in mice. Sixteen 24-week-old male C57BL/6 mice were used to establish SAON by two intraperitoneal injections of lipopolysaccharide (LPS), followed by three subcutaneous injections of methylprednisolone (MPS). Each injection was conducted on working day, with an interval of 24 h.

Steep Posterior Tibial Slope and Excessive Anterior Tibial Translation Are Associated With Increased Sagittal Meniscal Extrusion After Posterior Lateral Meniscus Root Repair Combined With Anterior Cruciate Ligament Reconstruction.

Purpose: To (1) evaluate the clinical and radiographic outcomes of patients with primary anterior cruciate ligament reconstruction (ACLR) with type II posterior lateral meniscus root tear (PLMRT) repair and (2) identify whether increased anterior tibial subluxation of the lateral compartment (ATSLC) and steeper posterior tibial slope (PTS) are associated with sagittal lateral meniscal extrusion (LME).

Methods: Patients who underwent primary anatomic ACLR with concomitant type II PLMRTs using the all-inside side-to-side repair technique between November 2014 and September 2020 were identified. To be included, patients must have had a minimum of 2 years follow-up.

Effectiveness of Corticosteroid Therapy in Enhancing Early Postoperative Recovery in Lumbar Spinal Stenosis Patients: A Retrospective Study.

BACKGROUND The degree of postoperative symptom improvement in patients with lumbar spinal stenosis (LSS) is crucial to their postoperative rehabilitation process and functional exercise. Corticosteroids have certain anti-inflammatory effects. This study aimed to explore whether small doses of corticosteroids would improve postoperative neurological symptoms in patients with lumbar spinal stenosis.

Artificial Intelligence in Scoliosis: Current Applications and Future Directions.

Scoliosis is a three-dimensional deformity of lateral bending and rotation of the spine. Artificial intelligence (AI) is a set of theories and techniques for studying artificial intelligence, which realizes machine intelligence by simulating and expanding human intelligence. With the continuous development of the multidisciplinary integration trend of modern medicine, artificial intelligence is used more and more in the diagnosis and treatment of scoliosis.

Unilateral interlaminar fenestration on the convex side provides a reliable access for intrathecal administration of nusinersen in spinal muscular atrophy: a retrospective study.

Background: As the first gene therapy for spinal muscular atrophy (SMA), nusinersen is supposed to be administrated via intrathecal injection regularly for a lifetime. However, for SMA patients with severe spinal deformities, bony fusion following posterior spinal instrumentation sets great obstacles for the application of nusinersen. Therefore, efforts have been devoted to the exploration of appropriate approach for nusinersen administration.

A two-dimensional hydrodynamics prediction framework for mantle-undulated propulsion robot using multiple proper orthogonal decomposition and long short term memory neural network.

In this paper, a deep learning based framework has been developed to predict hydrodynamic forces on a mantle-undulated propulsion robot (MUPRo). A multiple proper orthogonal decomposition (MPOD) algorithm has been proposed to efficiently identify fluid features near the undulating mantle of the MUPRo globally and locally. The results indicate that theL2error of the solution states near the undulating boundary of the proposed MPOD algorithm converges almost linearly to 0.

Silicon Micromachined TSVs for Backside Interconnection of Ultra-Small Pressure Sensors.

This paper presents an ultra-small absolute pressure sensor with a silicon-micromachined TSV backside interconnection for high-performance, high spatial resolution contact pressure sensing, including flexible-substrate applications. By exploiting silicon-micromachined TSVs that are compatibly fabricated with the pressure sensor, the sensing signals are emitted from the chip backside, thereby eliminating the fragile leads on the front-side. Such a design achieves a flat and fully passivated top surface to protect the sensor from mechanical damage, for reliable direct-contact pressure sensing.

Intraband Transition of HgTe Nanocrystals for Long-Wave Infrared Detection at 12 μm.

The synthesis of n-doped HgTe colloidal quantum dots was optimized to produce samples with a 1S-1P intraband transition in the long-wave infrared (8-12 μm). The spin-orbit splitting of 1P states places the 1S-1P transition around 10 μm. The narrow line width of 130 cm at 300 K is limited by the size distribution.

1ppm-detectable hydrogen gas sensors by using highly sensitive P+/N+ single-crystalline silicon thermopiles.

Hydrogen (H) is currently of strategic importance in the pursuit of a decarbonized, environmentally benign, sustainable global energy system; however, the explosive nature of H requires leakage monitoring to ensure safe application in industry. Therefore, H gas sensors with a high sensitivity and fast response across a wide concentration range are crucial yet technically challenging. In this work, we demonstrate a new type of MEMS differential thermopile gas sensor for the highly sensitive, rapid detection of trace H gas in air.

An integrated nomogram combining deep learning, clinical characteristics and ultrasound features for predicting central lymph node metastasis in papillary thyroid cancer: A multicenter study.

Objective: Central lymph node metastasis (CLNM) is a predictor of poor prognosis for papillary thyroid carcinoma (PTC) patients. The options for surgeon operation or follow-up depend on the state of CLNM while accurate prediction is a challenge for radiologists. The present study aimed to develop and validate an effective preoperative nomogram combining deep learning, clinical characteristics and ultrasound features for predicting CLNM.

Ultra-Responsive MEMS Sensing Chip for Differential Thermal Analysis (DTA).

Ultra-responsive single-crystal silicon MEMS thermopiles for differential thermal analysis (DTA) are developed. Facilitated by a unique "microholes interetch and sealing (MIS)" technique, pairs of suspended thermopiles are batch fabricated in a differential form, with high-density (54 pairs) n-type/p-type single-crystal silicon thermocouples integrated within each thermopile (sample area ~0.045 mm).

Poorer surgical outcomes at 2 years postoperatively in patients with lumbar spinal stenosis with long-term preoperative leg numbness: a single-center retrospective study.

Background: The purpose of this study was to assess whether differences in duration of preoperative leg numbness lead to different surgical outcomes.

Methods: This study included patients with lumbar spinal stenosis (LSS) who underwent lumbar fusion surgery in our hospital from January 2018 to September 2020. Patients were divided into three groups based on duration of preoperative leg numbness: no numbness (NN) group, short-term numbness (STN) group (leg numbness ≤ 3 months) and long-term numbness (LTN) group (leg numbness > 3 months).

The regrouping of Luminal B (HER2 negative), a better discriminator of outcome and recurrence score.

Background: Breast cancer (BC) remains the leading cause of cancer-related deaths worldwide. High recurrence risk Luminal BC receives adjuvant chemotherapy in addition to standard hormone therapy. Considering the heterogeneity of Luminal B BC, a more accurate classification model is urgently needed.

Propulsion optimization of a jellyfish-inspired robot based on a nonintrusive reduced-order model with proper orthogonal decomposition.

In this research, the propulsion of the proposed jellyfish-inspired mantle undulated propulsion robot (MUPRo) is optimized. To reliably predict the hydrodynamic forces acting on the robot, the proposed nonintrusive reduced-order model (NIROM) based on proper orthogonal decomposition (POD) additionally considers the POD basis that makes an important contribution to the features on the specified boundary. The proposed model establishes a mapping between the parameter-driven motion of the mantle and the evolution of the fluid characteristics around the swimmer.

Chip-Based MEMS Platform for Thermogravimetric/Differential Thermal Analysis (TG/DTA) Joint Characterization of Materials.

Combined use of thermal analysis techniques can realize complementarity of different characterization methods. Comprehensive thermal analysis with both thermogravimetric analysis and differential thermal analysis (TG/DTA) can measure not only mass change of a sample but also its temperature change during programmed heating-induced reaction or phase transition processes, thereby obtaining multiaspect thermal information of the material such as dehydration, structural decomposition, phase change and thermal stability. This study proposes and develops a MEMS chip-based TG/DTA microsystem that integrates both programmed heating and detecting elements into a TG chip and a DTA chip to enable the microinstrument performing TG/DTA joint characterization under microscope observation.

The role of F-FDG PET/CT metabolic parameters in pediatric lymphoblastic lymphoma.

Objective: This retrospective study aimed to evaluate the role of metabolic parameters of F-FDG PET/CT in pediatric lymphoblastic lymphoma (LBL).

Methods: Thirty patients with LBL underwent 42 scans. Metabolic parameters including maximum standardized uptake value (SUV), total metabolic tumor volume (TMTV), and total lesion glycolysis (TLG) were measured at baseline PET/CT.

The lanthanide doping effect on toluene catalytic oxidation over Pt/CeO catalyst.

The present work was undertaken to know the lanthanide doping effect on the physicochemical properties of Pt/CeO catalysts and their catalytic activity for toluene oxidation. A series of lanthanide ions (La, Pr, Nd, Sm and Gd) were incorporated into ceria lattice by hydrothermal method, and the Pt nanoparticles with equal quality were successfully loaded on various ceria-based supports. Their catalytic performance toward toluene oxidation shows a remarkable lanthanide-doping effect, and the activity is much dependent on the ion radius and valence state of dopants.

Effect of personality traits on rehabilitation effect after anterior cruciate ligament reconstruction: An observational study.

Background: Anterior cruciate ligament (ACL) reconstruction requires an extended period of postoperative rehabilitation. Psychological factors can affect recovery after surgery. Study of psychological factors is still limited to self-motivation, fear and pain.

Comparison of Function- and Activity-Related Outcomes After Anterior Talofibular Ligament Repair With 1 Versus 2 Suture Anchors.

Background: Few studies have compared the clinical outcomes of using 1 versus 2 suture anchors for anterior talofibular ligament (ATFL) repair.

Purpose: To compare the function and activity-related outcomes of arthroscopic ATFL repair using 1 versus 2 suture anchors.

Study Design: Cohort study; Level of evidence, 3.

H-Plasty Repair Technique Improved Tibiofemoral Contact Mechanics After Repair for Adjacent Radial Tears of Posterior Lateral Meniscus Root: A Biomechanical Study.

Purpose: To compare the time-zero tibiofemoral contact mechanics among the 4 different suturing repairs: transtibial pullout suture repair, suture anchor repair, side-to-side repair, and H-plasty repair.

Methods: Twenty-four human cadaveric knees were included. Each lateral meniscus condition (intact, radial tear, and repair) was tested under a 1000-N axial compressive load at 0°, 30°, 60°, and 90° of flexion.

Tibiofemoral Contact Mechanics After Horizontal or Ripstop Suture in Inside-Out and Transtibial Repair for Meniscus Radial Tears in a Porcine Model.

Purpose: To compare tibiofemoral contact mechanics after horizontal or ripstop (horizontal plus vertical) sutures in inside-out and transtibial repair for meniscal radial tears with 10 porcine knees in each group.

Methods: Ten matched pairs of porcine knees were tested under a 1500-N axial compressive load at 0°, 30°, 60°, and 90° of knee flexion. Each knee underwent 4 testing conditions consecutively: (1) intact, (2) medial meniscal radial tear, (3) horizontal suture repair configuration, and (4) ripstop suture repair configuration.

A novel surgical technique for arthroscopic repair of type II posterior lateral meniscal root tear.

Background: Several suture repair techniques have been reported for radial tear close to the posterior lateral meniscal root (type II PLMRT). However, no study has evaluated the clinical results after repair using the FasT-Fix system. This paper describes a novel H-plasty surgical repair technique and reports its clinical results.