Design, synthesis, and antitumor activity evaluation of 1,2,3-triazole derivatives as potent PD-1/PD-L1 inhibitors.

A series of 1,2,3-triazole derivatives targeting the PD-1/PD-L1 pathway were designed, synthesized, and evaluated both in vitro and in vivo. Among them, compound III-4 demonstrated exceptional inhibitory activity against the interaction of PD-1/PD-L1 and showed great binding affinity with hPD-L1, with an IC value of 2.9 nM and a K value of 3.

Mechanism of balloon burst during transcatheter aortic valve replacement pre-dilatation: Image observation and validation by finite element analysis.

Background: Balloon burst during transcatheter aortic valve replacement (TAVR) is serious complication. This study pioneers a novel approach by combining image observation and computer simulation validation to unravel the mechanism of balloon burst in a patient with bicuspid aortic valve (BAV) stenosis.

Method: A new computational model for balloon pre-dilatation was developed by incorporating the element failure criteria according to the Law of Laplace.

Application of time-domain gating technique in water content measurement of gas-liquid two-phase flow.

This paper introduces an application of the time-domain gating technique in water content measurement of gas-liquid two-phase flow. According to the principle that water and gas have different absorption effects on microwaves, a sensor with transmitting and receiving antennas is designed. Combined with the back propagation neural network, the water content of two-phase fluids can be obtained from the complex transmission coefficient (S) of antennas.

Anomalous interaction of Airy beams in the fractional nonlinear Schrödinger equation.

We investigate the mutual interaction of two spatially-separated Airy beams in the nonlinear Schrödinger equation with the fractional Laplacian. Depending on the beam separation (), relative phase and Lévy index (), we observed an anomalous attraction or repulsion between the Airy beams. Anomalous attraction leads to a single breather soliton with a period that grows exponentially as increases.

XYZLMS interim connection space for spectral image compression and reproduction.

To improve the spectral image representation and reproduction accuracy, an interim connection space (ICS) was proposed. Three offset functions were defined to make up the wave regions uncovered by the CIEXYZ color matching functions. The XYZLMS ICS was determined based on the CIEXYZ and defined offset functions.