Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation.

As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms. Recent advances in single-cell technology have enabled simultaneous profiling of transcriptome-wide RNA methylation in thousands of cells, holding the promise to provide deeper insights into the dynamics, functions, and regulation of RNA methylation. However, it remains a major challenge to determine how to best analyze single-cell epitranscriptomics data.

Polymorphism of Pb(PO)OH within the LK-99 mixture.

During the synthetic exploration targeting the polycrystalline compound LK-99, an unexpected phase, Pb(PO)OH, was identified as a byproduct. We elucidated the composition of this compound through single-crystal X-ray diffraction analysis. Subsequent synthesis of the target compounds was achieved via high-temperature solid-state pellet reactions.

POM-Based Hydrogels for Efficient Synergistic Chemodynamic/Low-Temperature Photothermal Antibacterial Therapy.

Bacterial infection of wound surfaces has posed a significant threat to human health and represents a formidable challenge in the clinical treatment. In this study, a novel antimicrobial hydrogel utilizing POM is synthesized as the primary component, with gelatin and sodium alginate as the structural framework. The resultant hydrogel demonstrates exceptional mechanical properties and viscoelasticity attributed to the hydrogen-bonded cross-linking between POM and gelatin, as well as the ionic cross-linking between sodium alginate and Ca.

Pseudosymmetry in Tetragonal Perovskite SrIrO Synthesized under High Pressure.

In this study, we report a tetragonal perovskite structure of SrIrO (4/, = 3.9362(9) Å, = 7.880(3) Å) synthesized at 6 GPa and 1400 °C, employing the ambient pressure monoclinic SrIrO with distorted 6 structure as a precursor.

Experimental and numerical study on explosion resistance of polyurea-coated shelter in petrochemical industry.

To reduce the number of casualties in explosion accidents, blast-resistant shelters can be used to protect personnel in high-risk areas of petrochemical processing plants. In this work, the deformation behaviours of uncoated and polyurea-coated blast-resistant plates were studied through gas explosion tests. An ANSYS/LS-DYNA model of a polyurea-coated shelter was established, and the dynamic responses of the shelter under various explosion loads were analysed.

Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons.

Intestinal helminth infection triggers a type 2 immune response that promotes a 'weep-and sweep' response characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its intestinal habitat. Recent studies have discovered that several other pathogens cause intestinal dysmotility through major alterations to the immune and enteric nervous systems (ENS), and their interactions, within the gastrointestinal tract. However, the involvement of these systems has not been investigated for helminth infections.

Uncovering the phonon spectra and lattice dynamics of plastically deformable InSe van der Waals crystals.

Stacking two-dimensional (2D) van der Waals (vdW) materials in a layered bulk structure provides an appealing platform for the emergence of exotic physical properties. As a vdW crystal with exceptional plasticity, InSe offers the opportunity to explore various effects arising from the coupling of its peculiar mechanical behaviors and other physical properties. Here, we employ neutron scattering techniques to investigate the correlations of plastic interlayer slip, lattice anharmonicity, and thermal transport in InSe crystals.

Volatile Organic Compounds Mediate Host Selection of Wheat Midge, Sitodiplosis Mosellana (Géhin) (Diptera: Cecidomyiidae) between Preanthesis and Postanthesis Stages of Wheat.

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae), is a significant wheat pest in the Prairie Provinces of Canada and northern regions of the USA. Wheat phenology plays a critical role in wheat midge oviposition. We hypothesized that S.

In situ replacement of a failed implant to rescue a complete arch fixed prosthesis: A dental technique.

Implant failure may occur after the delivery of definitive prostheses. Avoiding replacement of a complete arch implant-supported fixed prosthesis becomes a significant challenge when placement of a new implant is necessary. This technical article introduces a protocol to replace a failed implant in situ, effectively rescuing the original prosthesis.

Long-Range Structural Order in a Hidden Phase of Ruddlesden-Popper Bilayer Nickelate LaNiO.

The recent discovery of superconductivity in the Ruddlesden-Popper bilayer nickelate, specifically LaNiO, has generated significant interest in the exploration of high-temperature superconductivity within this material family. In this study, we present the crystallographic and electrical resistivity properties of two distinct Ruddlesden-Popper nickelates: the bilayer LaNiO (referred to as 2222-phase) and a previously uncharacterized phase, LaNiO (1313-phase). The 2222-phase is characterized by a pseudo -centered orthorhombic lattice, featuring bilayer perovskite [LaNiO] layers interspaced by rock salt [LaO] layers, forming a repeated .

Genome-wide identification of GA2ox genes family and analysis of PbrGA2ox1-mediated enhanced chlorophyll accumulation by promoting chloroplast development in pear.

Background: Chlorophyll (Chl) is an agronomic trait associated with photosynthesis and yield. Gibberellin 2-oxidases (GA2oxs) have previously been shown to be involved in Chl accumulation. However, whether and how the PbrGA2ox proteins (PbrGA2oxs) mediate Chl accumulation in pear (Pyrus spp.

Is LaNiO a Bulk Superconducting Nickelate?

Superconducting states onsetting at moderately high temperatures have been observed in epitaxially stabilized NiO-based thin films. However, recently, it has also been reported that superconductivity at high temperatures is observed in bulk LaNiO at high pressure, opening further possibilities for study. Here we report the reduction profile of LaNiO in a stream of 5% H/Ar gas and the isolation of the metastable intermediate phase LaNiO, which is based on Ni.

Structure-Dependence and Mechanistic Insights into the Piezoelectric Effect in Ionic Liquids.

We reported recently that two imidazolium room-temperature ionic liquids (RTILs) exhibit the direct piezoelectric effect (, , 14, 2731-2735). We have subsequently investigated several other RTILs with pyrrolidinium and imidazolium cations and tetrafluoroborate and bis(trifluoromethylsulfonyl)imide anions in an effort to gain insight into the generality and mechanism of the effect. All the RTILs studied exhibit the direct piezoelectric effect, with a magnitude () and threshold force that depend on the structures of both the cation and anion.

prediction aided preparation of antioxidant soybean peptides by enzymatic hydrolysis for ameliorating lead exposure-induced toxicity.

Food derived bioactive peptides are prominent dietary supplements to protect against oxidative stress induced by lead (Pb) exposure. This study aimed to develop a new strategy for rapid preparation of highly active antioxidant soybean polypeptides (ASPs) against Pb toxicity. enzymatic hydrolysis simulation and antioxidant activity prediction showed that pepsin, chymotrypsin and bromelain can produce peptides with the highest activity.

In vitro acaricidal activity of essential oils and their binary mixtures against ixodes scapularis (Acari: Ixodidae).

Ixodes scapularis ticks are vectors of infectious agents that cause illness in humans, including Lyme disease. Recent years have seen a surge in tick-borne diseases (TBD) resulting in a high demand for tick management products. Plants offer a valuable source of active compounds for the development of novel, eco-friendly tick control products, reducing potential risks to human and animal health.

Strong enhancement of magnetic ordering temperature and structural/valence transitions in EuPdS under high pressure.

We present a comprehensive study of the inhomogeneous mixed-valence compound, EuPdS, by electrical transport, X-ray diffraction, time-domain Eu synchrotron Mössbauer spectroscopy, and X-ray absorption spectroscopy measurements under high pressure. Electrical transport measurements show that the antiferromagnetic ordering temperature, , increases rapidly from 2.8 K at ambient pressure to 23.

The pressure-stabilized polymorph of indium triiodide.

A layered rhombohedral polymorph of indium(III) triiodide is synthesized at high pressure and temperature. The unit cell symmetry and approximate dimensions are determined by single crystal X-ray diffraction. Its 3̄ crystal structure, with = 7.

Utilization of brain scans to create realistic phosphene maps for cortical visual prosthesis simulation studies.

It has been shown that we can restore sensations of light by stimulating the visual cortex. Cortical prosthetic vision consists of light perception in the visual field named phosphenes. Phosphenes are like pixels on a monitor which we can control to form the desired perception.

Purslane (Portulacae oleracea L.) polysaccharide relieves cadmium-induced colonic impairments by restricting Cd accumulation and inhibiting inflammatory responses.

This study aimed to assess the protective effects of purslane polysaccharide (PP) on colonic impairments in mice exposed to cadmium (Cd). C57BL/6 mice were administered with PP (200-800 mg/kg/day) by gavage for 4 weeks after treatment with 100 mg·L CdCl. PP significantly reduced Cd accumulation in the colon tissue and promoted the excretion of Cd in the feces.

Cascaded compression of size distribution of nanopores in monolayer graphene.

Monolayer graphene with nanometre-scale pores, atomically thin thickness and remarkable mechanical properties provides wide-ranging opportunities for applications in ion and molecular separations, energy storage and electronics. Because the performance of these applications relies heavily on the size of the nanopores, it is desirable to design and engineer with precision a suitable nanopore size with narrow size distributions. However, conventional top-down processes often yield log-normal distributions with long tails, particularly at the sub-nanometre scale.

Incommensurate Spiral Spin Order in CaMnBi Observed via High-Pressure Neutron Diffraction.

High-pressure neutron diffraction is employed to investigate the magnetic behavior of CaMnBi in extreme conditions. In contrast to antiferromagnetic ordering on Mn atoms reported at ambient pressure, our results reveal that at high pressure, incommensurate spiral spin order emerges due to the interplay between magnetism on the Mn atoms and strong spin-orbit coupling on the Bi atoms: sinusoidal spin order is observed at pressures as high as 7.4 GPa.

Continuous Spin Excitations in the Three-Dimensional Frustrated Magnet K_{2}Ni_{2}(SO_{4})_{3}.

Continuous spin excitations are widely recognized as one of the hallmarks of novel spin states in quantum magnets, such as quantum spin liquids (QSLs). Here, we report the observation of such kind of excitations in K_{2}Ni_{2}(SO_{4})_{3}, which consists of two sets of intersected spin-1 (Ni^{2+}) trillium lattices. Our inelastic neutron scattering measurement on single crystals clearly shows a dominant excitation continuum, which exhibits a distinct temperature-dependent behavior from that of spin waves, and is rooted in strong quantum spin fluctuations.