Publications by authors named "Haozhe Fan"
Article Synopsis
- Hyperforin (HYP) was studied for its effects on inflammation and acute kidney injury (AKI) induced by lipopolysaccharide (LPS) in mouse models.
- The study found that HYP improved survival rates in septic mice, reduced podocyte apoptosis, and countered AKI, suggesting it acts as an inhibitor of a signaling pathway involving NF- and miR-21.
- These results indicate that targeting the NF-/miR-21 signaling pathway could be a promising therapeutic approach using HYP to protect against AKI.
Article Synopsis
- - Patients with trisomy 8 are often associated with myeloid neoplasms and inflammatory disorders, with Behçet's disease being the most common type linked to myelodysplastic syndromes (MDS), while other inflammatory conditions are less recognized.
- - A case of a 27-year-old man highlighted severe pulmonary inflammation and infection linked to trisomy 8, where treatments included antibiotics and ultimately methylprednisolone.
- - The findings suggest that severe pulmonary inflammatory disorders can occur in trisomy 8 patients, and methylprednisolone may be an effective treatment option for managing this condition.
Background: Acute respiratory distress syndrome (ARDS) is a very common disease in the intensive care unit (ICU), with rapid progression and high mortality. Infections caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can easily progress to ARDS in severely ill patients. Early and rapid diagnosis as well as screening for ARDS during treatment is very important.
View Article and Find Full Text PDFThe Role of Lung Ultrasound in the Assessment of Novel Coronavirus Pneumonia.
J Cardiothorac Vasc Anesth
October 2020
Sedatives are commonly used for mechanically ventilated patients in intensive care units (ICU). However, a variety of sedatives are available and their efficacy and safety have been compared in numerous trials with inconsistent results. To resolve uncertainties regarding usefulness of these sedatives, we performed a systematic review and network meta-analysis.
View Article and Find Full Text PDFBackground And Objectives: Hyperlactatemia has long been associated with poor clinical outcome in varieties of intensive care unit (ICU) patients. However, the impact of temporal changes in lactate has not been well established and there are some shortcomings in model building in previous studies. The present study aims to investigate the association of initial lactate and normalization time with hazard by using fractional polynomial Cox proportional hazard model.
View Article and Find Full Text PDFDose determination in continuous renal replacement therapy (CRRT) is controversial. Most clinical trials use effluent flow rate as a surrogate of the dose. However, such definition may overestimate actually delivered dose due to declining filter function.
View Article and Find Full Text PDFBackground: Chloride administration has been found to be harmful to the kidney in critically ill patients. However the association between plasma chloride concentration and renal function has never been investigated.
Methods: This was a retrospective study conducted in a tertiary 24-bed intensive care unit from September 2010 to November 2012.
Background: Hemodynamic monitoring is very important in critically ill patients with shock or acute respiratory distress syndrome(ARDS). The PiCCO (Pulse index Contour Continuous Cardiac Output, Pulsion Medical Systems, Germany) system has been developed and used in critical care settings for several years. However, its impact on clinical outcomes remains unknown.
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