VCAN in the extracellular matrix drives glioma recurrence by enhancing cell proliferation and migration.

Introduction: Gliomas are the most prevalent primary malignant intracranial tumors, characterized by high rates of therapy resistance, recurrence, and mortality. A major factor contributing to the poor prognosis of gliomas is their ability to diffusely infiltrate surrounding and even distant brain tissues, rendering complete total resection almost impossible and leading to frequent recurrences. The extracellular matrix (ECM) plays a key role in the tumor microenvironment and may significantly influence glioma progression, recurrence, and therapeutic response.

Land Subsidence in Qingdao, China, from 2017 to 2020 Based on PS-InSAR.

Land subsidence is a global geological disaster that seriously affects the safety of surface and underground buildings/structures and even leads to loss of life and property. The large-scale and continuous long-time coverage of Interferometric Synthetic Aperture Radar (InSAR) time series analysis techniques provide data and a basis for the development of methods for the investigation and evolution mechanism study of regional land subsidence. Based on the 108 SAR data of Sentinel-1 from April 2017 to December 2020, this study used Persistent Scatterer InSAR (PS-InSAR) technology to monitor the land subsidence in Qingdao.