New Advances in Periodontal Functional Materials Based on Antibacterial, Anti-Inflammatory, and Tissue Regeneration Strategies.

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, is gaining attention. Current novel biomaterials address key clinical issues like bacterial infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, and tissue regeneration properties.

Dynamic Covalent Prodrug Nanonetworks via Reaction-Induced Self-Assembly for Periodontitis Treatment.

Periodontitis is characterized by dysbiotic biofilms, gingival inflammation, and bone resorption, highlighting the urgent need for a comprehensive approach to drug combination therapy. In this study, we introduce dynamic covalent nanonetworks (dcNNWs) synthesized through a one-pot, four-component reaction-induced self-assembly method using polyamines, 2-formylphenylboronic acid, epigallocatechin gallate, and alendronate. The formation of iminoboronate bonds drives the creation of dcNNWs, allowing controlled release in the periodontitis microenvironment.

Digital finance, capital-biased and labor-biased technical progress: Important grips for mitigating carbon emission inequality.

As an innovative financial model in the era of the digital economy, digital finance, with its inclusive characteristics, provides effective financial support for the realization of the carbon peak and carbon neutrality. To realize the "double carbon" goal, it is necessary not only to control the total amount and intensity of carbon emissions but also to consider the coordination and fairness of carbon emission reduction between regions. The existing literature has discussed the carbon reduction effect of digital finance, but few studies have focused on the impact and mechanism of digital finance on regional carbon emission inequality.

Recent Development of Nanozymes for Combating Bacterial Drug Resistance: A Review.

The World Health Organization has warned that without effective action, deaths from drug-resistant bacteria can exceed 10 million annually, making it the leading cause of death. Conventional antibiotics are becoming less effective due to rapid bacterial drug resistance and slowed new antibiotic development, necessitating new strategies. Recently, materials with catalytic/enzymatic properties, known as nanozymes, have been developed, inspired by natural enzymes essential for bacterial eradication.

Unraveling anti-aging mystery of green tea in C. elegans: Chemical truth and multiple mechanisms.

Tea drinking impacts aging and aging-related diseases. However, knowledge of anti-aging molecules other than the major catechins in complex tea extracts remains limited. Here we used Caenorhabditis elegans to analyze the longevity effects of tea extracts and constituents comprehensively.

Unlocking a greener future: The role of digital finance in enhancing green total factor energy efficiency.

The development of digital finance provides new opportunities for improving energy efficiency and promoting green development. This paper calculates green total factor energy efficiency (GTFEE) using the super-efficiency SBM model and examines the impact of digital finance on GTFEE. Digital finance has a significant positive impact on GTFEE.

CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia-related mutations in men.

Oligoasthenoteratospermia (OAT), characterized by abnormally low sperm count, poor sperm motility, and abnormally high number of deformed spermatozoa, is an important cause of male infertility. Its genetic basis in many affected individuals remains unknown. Here, we found that CCDC157 variants are associated with OAT.

Spatial autocorrelation and driving factors of carbon emission density of crop production in China.

Mitigating carbon emissions from crop production is essential for addressing global warming. At a macro-level, existing studies have often relied on the calculation of carbon emission intensity of crop production to understand comparable carbon effects between regions. However, this approach obscures the differences in crop planting scale and natural attributes across regions, leaving room for improvement in the methods and scope of analysis.

Chondromyxoid fibroma of the lumbar facet joint: A case report.

Chondromyxoid fibroma (CMF) is a rarely documented benign osseous neoplasm, particularly with respect to its incidence in the lumbar spinal region. CMF predominantly manifests in vertebral bodies, exhibiting atypical emergence in ancillary anatomical sites. The present report describes, to the best of our knowledge, the second documented instance of CMF originating from the lumbar facet joint.

Computed tomography in measuring electrode insertion angle and depth for cricopharyngeal muscle electromyography.

Background: Electromyography of the cricopharyngeal muscle (CP-EMG) is one of many assessment tools for dysphagia. The key to performing EMG and BTX injections is to precisely locate the cricopharyngeal muscle with an electrode. One of the main difficulties of electrode insertion is the fact that the CP muscle is located deep within the neck.

The role of m6A methylation in prenatal maternal psychological distress and birth outcome.

Background: Prenatal maternal psychological distress (PMPD) is a known risk factor for adverse birth outcomes. N6-methyladenosine RNA (m6A) methylation is crucial in moderating RNA biology. This study aimed to evaluate the relationships between PMPD, birth outcomes, and placental m6A methylation.

Prolactin and glucocorticoid receptors in the prefrontal cortex are associated with anxiety-like behavior in prenatally stressed adolescent offspring rats.

Prenatal stress (PS) causes anxiety in mothers and their offspring and chewing is a commonly observed behavior during maternal stress. Prolactin (PRL) is an anti-anxiety factor that suppresses the hypothalamic-pituitary-adrenal axis. Here, we studied the roles of PRL, corticosterone (CORT), and their receptors in PS-induced anxiety-like behavior in dams and their offspring.

METTL14 Regulates Intestine Cellular Senescence through mA Modification of Lamin B Receptor.

N-6-Methyladenosine (mA) modification is involved in multiple biological processes including aging. However, the regulation of mA methyltransferase-like 14 (METTL14) in aging remains unclear. Here, we revealed that the level of mA modification and the expression of METTL14 were particularly decreased in the intestine of aged mice as compared to young mice.

Facile solvothermal synthesis of nitrogen-doped SnO nanorods towards enhanced photocatalysis.

Heteroatom doping has proved to be one of the most effective approaches to further improve the photocatalytic activities of semiconducting oxides originating from the modulation of their electronic structures. Herein, nitrogen-doped SnO nanorods were synthesized facile solvothermal processes using polyvinylpyrrolidone (PVP) as a dispersing agent and ammonium water as the N source, respectively. Compared with pure SnO sample, the as-synthesized nitrogen-doped SnO nanorods demonstrated enhanced photocatalytic performances, evaluated by the degradation of rhodamine B (RhB), revealing the effectiveness of nitrogen doping towards photocatalysis.

Associations between maternal prenatal depression and neonatal behavior and brain function - Evidence from the functional near-infrared spectroscopy.

Background: Maternal prenatal depression is a significant public health issue associated with mental disorders of offspring. This study aimed to determine if maternal prenatal depressive symptoms are associated with changes in neonatal behaviors and brain function at the resting state.

Methods: A total of 204 pregnant women were recruited during the third trimester and were evaluated by Edinburgh Postpartum Depression Scale (EPDS).

Brain Activation Site of Laryngeal Elevation During Swallowing: An fMRI Study.

The object of this study is to investigate dysphagia caused by reduced laryngeal elevation in patients poststroke. The central mechanism of laryngeal elevation during swallowing was explored by comparing the brain activation area before and after treatment with that of healthy subjects. The treatment group included patients diagnosed with dysphagia poststroke that showed reduced laryngeal elevation.

Phosphatase of Regenerating Liver-1 Regulates Wing Vein Formation through TGF-β Pathway in .

Background: Phosphatase of Regenerating Liver-1 (PRL-1) is the only homolog of the mammalian PRLs with which it shares high sequence and structural similarities. Whilst PRLs are most notable for their high expression in malignant cancers and related promotion of cancer progression, the specific biological functions of the PRLs remain largely elusive.

Methods: Here, using a gain-of-function approach, we found that PRL-1 functions during wing vein development in ().

A novel PM2.5 concentrations probability density prediction model combines the least absolute shrinkage and selection operator with quantile regression.

PM2.5 has a significant negative impact on human health and atmospheric quality, and accurate prediction of its concentration is necessary. When using common point prediction models for PM2.

The Effects of COVID-19 Risk Perception on Travel Intention: Evidence From Chinese Travelers.

This study attempts to assess the relationship between risk perception, risk knowledge, and travel intentions of Chinese leisure travelers during the COVID-19 pandemic in the framework of social contagion and risk communication theories by analyzing a sample of 1,209 travelers through structural equation modeling (SEM) and path analysis. We used the process macro of Hayes to analyze the moderation effects of age, gender, and education between risk perception, media and interpersonal communication, and risk knowledge. It was found that travelers were more concerned about self-efficacy than severity.

GDC-0326 Enhances the Effects of 5-Fu in Colorectal Cancer Cells by Inducing Necroptotic Death.

Aim: Chemoresistance to 5-fluorouracil (5-Fu) is common in colorectal cancer (CRC). Programmed necrosis (necroptosis) is an alternative form of programmed cell death regulated by receptor-interacting protein kinase (RIPK) 1 and 3, assumed as a novel target of cancer therapy. In this study, we aimed to explore whether a novel small molecular agent GDC-0326 could facilitate the effect of 5-Fu through necroptosis.

Discovery of Neolignan Glycosides with Acetylcolinesterase Inhibitory Activity from Huangjinya Green Tea Guided by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Data and Global Natural Product Social Molecular Networking.

Global Natural Product Social feature-based networking was applied to follow the phytochemicals, including nine flavonoid glycosides, six catechins, and three flavonols in Huangjinya green tea. Further, a new 8--4'-type neolignan glycoside, camellignanoside A (), and 15 known compounds (-) were isolated through a variety of column chromatographies, and the structure was elucidated extensively by ultra performance liquid chromatography-quadrupole-time-of-flight-tandem mass spectrometry, H and C nuclear magnetic resonance, heteronuclear single-quantum correlation, heteronuclear multiple-bond correlation, H-H correlation spectroscopy, rotating frame nuclear Overhauser effect spectroscopy, and Nuclear Overhauser effect spectroscopy, and circular dichroism spectroscopies. Compounds and showed acetylcolinesterase inhibition activity, with IC = 0.

Two Pairs of Isomerically New Phenylpropanoidated Epicatechin Gallates with Neuroprotective Effects on HO-Injured SH-SY5Y Cells from Zijuan Green Tea and Their Changes in Fresh Tea Leaves Collected from Different Months and Final Product.

Zijuan tea ( Camellia sinensis var. assamica), an anthocyanin-rich cultivar with purple leaves, is a valuable material for manufacturing tea with unique color and flavor. In this paper, four new phenylpropanoid substituted epicatechin gallates (pECGs), Zijuanins A-D (1-4), were isolated from Zijuan green tea by different column chromatography.

Inhibition of α-glucosidase and α-amylase by flavonoid glycosides from Lu'an GuaPian tea: molecular docking and interaction mechanism.

Green tea may favorably modulate blood glucose homeostasis, and regular consumption of green tea can prevent the development of type 2 diabetes mellitus. In this study, α-glucosidase and α-amylase inhibitory effects of the novel acylated flavonol tetraglycoside (camellikaempferoside C, 1) and 14 other flavone and flavone glycosides (FGs) isolated from Lu'an GuaPian (Camellia sinensis L.O.