Publications by authors named "Haoyue Kuang"
Article Synopsis
- Microglia, the brain's resident immune cells, can self-renew, but how they age and are replaced is still unclear.
- In zebrafish, two sources of microglia are identified: early short-lifespan ones from the rostral blood island (RBI) and later long-lifespan ones from the aorta-gonad-mesonephros (AGM).
- The study finds that the decline of RBI microglia is linked to their poor competition for a key growth factor (Il34), and that age affects the overall maintenance and elimination of microglia through a process called cell competition.
Microglia are tissue-resident macrophages in the central nervous system (CNS) that play essential roles in the regulation of CNS development and homeostasis. Yet, the genetic networks governing microglia development remain incompletely defined. Here, we report the identification and characterization of a microglia-defective zebrafish mutant ( ) isolated from an ethylnitrosourea (ENU)-based genetic screen.
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