Publications by authors named "Haoyu Zha"
Objectives: To investigate the epidemiological characteristics of Augmented Renal Clearance (ARC) in severe sepsis children with MRSA infection and find risk factors to establish a model predicting ARC onset in PICU.
Design: Retrospective study, in which ARC was defined by estimated glomerular filtration rate (eGFR) measured by the modified Schwartz formula above 130 ml/min/1.73 m.
Article Synopsis
- - The study focuses on developing VEGFR-2 kinase inhibitors using an indazole structure, which is important for controlling tumor growth by blocking blood vessel formation.
- - The leading compound, 30, shows strong effectiveness in inhibiting VEGFR-2 with a low concentration needed (1.24 nM) and selectively targets it over other kinases.
- - In tests, compound 30 effectively limits blood vessel growth in cell models and shows low toxicity in mice, suggesting it has good potential for cancer treatment in future studies.
Synovial angiogenesis is essential for the development of rheumatoid arthritis (RA). Human vascular endothelial growth factor receptor 2 tyrosine kinase (VEGFR2) is a direct target gene that is notably elevated in RA synovium. Herein, we report the identification of indazole derivatives as a novel class of potent VEGFR2 inhibitors.
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