Frk positively regulates innate antiviral immunity by phosphorylating TBK1.

Type I interferons (IFN-I) are crucial for the initial defense against viral infections. TBK1 serves as a key regulator in the production of IFN-I, with its phosphorylation being essential for the regulation of its activity. However, the regulatory mechanisms governing its activation remain incompletely elucidated.

Artificial intelligence-driven quantitative analysis of CT morphological differences between chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease.

Background: The morphological differences in the pulmonary vascular tree between chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic disease (CTED) are not yet fully understood. This study aimed to use artificial intelligence (AI) segmentation technology to identify morphological markers that can be used to differentiate CTEPH from CTED using computed tomography pulmonary angiography (CTPA).

Methods: We conducted a retrospective cohort study with consecutive patients diagnosed with CTEPH, CTED, and control subjects at the China-Japan Friendship Hospital from January 2019 to October 2023.

Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES.

At present, the relationship between the intake of antioxidants in food and the mortality rate of patients with chronic kidney disease (CKD), especially the association with the mortality rate of specific causes, is not clear. This study included 6379 adult CKD patients from the National Health and Nutrition Examination Survey (2001-2018). Use the Cox proportional hazards model, restricted cubic spline (RCS) model, and stratified and sensitivity analysis to evaluate the relationship between the Composite Dietary Antioxidant Index (CDAI) and mortality in patients with chronic kidney disease.

Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: .

Background: Psoriasis represents a persistent, immune-driven inflammatory condition affecting the skin, characterized by a lack of well-established biologic treatments without adverse events. Consequently, the identification of novel targets and therapeutic agents remains a pressing priority in the field of psoriasis research.

Methods: We collected single-cell RNA sequencing (scRNA-seq) datasets and inferred T cell differentiation trajectories through pseudotime analysis.

Development of a machine learning model in prediction of the rapid progression of interstitial lung disease in patients with idiopathic inflammatory myopathy.

Background: Rapidly progressive interstitial lung disease (RP-ILD) significantly impacts the prognosis of patients with idiopathic inflammatory myopathies (IIM). High-resolution computed tomography (HRCT) is a crucial noninvasive technique for evaluating interstitial lung disease (ILD). Utilizing quantitative computed tomography (QCT) enables accurate quantification of disease severity and evaluation of prognosis, thereby serving as a crucial computer-aided diagnostic method.

Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating.

Recalling systems-consolidated neocortex-dependent remote memories re-engages the hippocampus in a process called systems reconsolidation. However, underlying mechanisms, particularly for the origin of the reinstated hippocampal memory engram, remain elusive. By developing a triple-event labeling tool and employing two-photon imaging, we trace hippocampal engram ensembles from memory acquisition to systems reconsolidation and find that remote recall recruits a new engram ensemble in the hippocampus for subsequent memory retrieval.

Microbial Synthesis of Nucleosides: Advances and Prospects.

Nucleosides and its derivatives are essential chemicals with extensive applications in the food, agricultural, and pharmaceutical industries. Chemical synthesis of these compounds often faces problems such as harsh reaction conditions and environmental pollution, whereas microbial synthesis provides a promising and sustainable alternative. This review discusses recent advances in the biosynthesis of nucleosides and their derivatives.

Optimizing continuous passive motion duration following arthroscopic release of elbow contracture: a retrospective study.

Background: The anatomical structure of the elbow joint makes it vulnerable to contractures. While elbow arthroscopy minimizes soft tissue damage and enhances early rehabilitation, the optimal duration for postoperative Continuous Passive Motion (CPM) therapy is unclear. This retrospective study aims to establish the appropriate duration of CPM following arthroscopic elbow contracture release.

Spatial resolution enhancement using deep learning improves chest disease diagnosis based on thick slice CT.

CT is crucial for diagnosing chest diseases, with image quality affected by spatial resolution. Thick-slice CT remains prevalent in practice due to cost considerations, yet its coarse spatial resolution may hinder accurate diagnoses. Our multicenter study develops a deep learning synthetic model with Convolutional-Transformer hybrid encoder-decoder architecture for generating thin-slice CT from thick-slice CT on a single center (1576 participants) and access the synthetic CT on three cross-regional centers (1228 participants).

snRNA-seq of adipose tissues reveals the potential cellular and molecular mechanisms of cold and disease resistance in Mongolian cattle.

Background: Mongolian cattle are local breeds in northern China with excellent adaptability to harsh environmental conditions. Adipose tissues play essential roles in tolerance to cold and disease, but the associated cellular and molecular mechanisms are unclear.

Methods: Single-nucleus RNA sequencing (snRNA-seq) was performed on the adipose tissues from the subcutaneous (SAT), greater omentum (OAT) and perirenal (PAT) of 3 healthy cattle.

Draft genome sequence of s sp. ZS001 isolated from peanut plantation soil.

sp. ZS001 is a bacterium potentially degrading soluble starch isolated from peanut plantation soil sprayed with starch-based material in Dasi Town, Tianjin. Reporting the genome sequence of strain ZS001 can help us understand the genome composition, potential functional characteristics, and application value of members at the genetic level.

Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood.

Background: Hematopoietic stem progenitor cells (HSPCs) undergo phenotypical and functional changes during their emergence and development. Although the molecular programs governing the development of human hematopoietic stem cells (HSCs) have been investigated broadly, the relationships between dynamic metabolic alterations and their functions remain poorly characterized.

Methods: In this study, we comprehensively described the proteomics of HSPCs in the human fetal liver (FL), umbilical cord blood (UCB), and adult bone marrow (aBM).

Outcome evaluation of dye-assist arthroscopic inside-out ganglionectomy: a retrospective study of 29 patients.

Objective: To evaluate the clinical outcomes of arthroscopic inside-out ganglionectomy of dominant dorsal wrist ganglion.

Methods: Patients with dominant wrist ganglion cyst treated in our hospital from January 1, 2014 to June 31, 2023 was enrolled in this retrospective analysis. All patients underwent dye-assist arthroscopic inside-out ganglionectomy.

Proteomic characterization of murine hematopoietic stem progenitor cells reveals dynamic fetal-to-adult changes in metabolic-related pathways.

Hematopoietic stem progenitor cells (HSPCs) give rise to the hematopoietic system, maintain hematopoiesis throughout the lifespan, and undergo molecular and functional changes during their development and aging. The importance of hematopoietic stem cell (HSC) biology has led to their extensive characterization at genomic and transcriptomic levels. However, the proteomics of HSPCs throughout the murine lifetime still needs to be fully completed.

SrAlO:Li,Mn phosphor-in-glass film: erosion behavior and luminescence property.

At present, phosphor-in-glass is regarded as a superior encapsulation material substituting for organic materials to resolve the poor thermal stability of WLEDs. However, the serious erosion reaction between commercial red phosphor and the glass matrix restricts the development and application of red phosphor-in-glass. In this work, a novel SrAlO:Li,Mn (SAO) red phosphor-in-glass film (PiGF) with precursor glass BO-(85 - )BiO-5AlO-10CaO was prepared using a low-temperature sintering technique.

Preparation and Application of Alpha Toxin Nanobodies.

All subtypes of () produce the alpha toxin (CPA), which can cause enteritis or enterotoxemia in lambs, cattle, pigs, and horses, as well as traumatic clostridial myonecrosis in humans and animals. CPA acts on cell membranes, ultimately leading to endocytosis and cell death. Therefore, the neutralization of CPA is crucial for the prevention and treatment of diseases caused by .

High-Throughput Screening and Prediction of Nucleophilicity of Amines Using Machine Learning and DFT Calculations.

Nucleophilic index () as a significant parameter plays a crucial role in screening of amine catalysts. Indeed, the quantity and variety of amines are extensive. However, only limited amines exhibit an value exceeding 4.

[Chemical composition and pharmacological effects of Cinnamomum camphora chvar. borneol essential oil: a review].

Cinnamomum camphora chvar. borneol, a rare camphor tree variant recently identified in China, is distinguished by its high concentration of D-borneol, also known as " plant gold" due to its significant value. The essential oil extracted from this variant,rich in monoterpenes and sesquiterpenes, demonstrates a broad spectrum of pharmacological activities, including analgesic, antiinflammatory, antioxidant, cognition-enhancing, anti-bacterial, and insecticidal effects.