Long-term outcomes of the BalMedic bovine pericardial bioprosthetic valve in female patients ≤50 years: a multicenter retrospective study.

Background: A bioprosthetic valve is recommended for women of childbearing age who require cardiac valve replacement in order to minimize the risk of blood clot formation. However, it should be noted that compared to mechanical valves, bioprosthetic valves have a shorter lifespan and a higher likelihood of requiring reoperation during follow-up. To assess the long-term postoperative results, including the incidence of structural valve deterioration (SVD) and other clinical outcomes, in female patients aged 50 years and younger who underwent BalMedic bovine pericardial bioprosthetic valve replacement, a multicenter retrospective study was implemented in China.

Emergent flat band and topological Kondo semimetal driven by orbital-selective correlations.

Flat electronic bands are expected to show proportionally enhanced electron correlations, which may generate a plethora of novel quantum phases and unusual low-energy excitations. They are increasingly being pursued in d-electron-based systems with crystalline lattices that feature destructive electronic interference, where they are often topological. Such flat bands, though, are generically located far away from the Fermi energy, which limits their capacity to partake in the low-energy physics.

A pilot study of virtual liver segment projection technology in subsegment-oriented laparoscopic anatomical liver resection when indocyanine green staining fails (with video).

Background: Precision surgery for liver tumors favors laparoscopic anatomical liver resection (LALR), involving the removal of specific liver segments or subsegments. Indocyanine green (ICG)-negative staining is a commonly used method for defining resection boundaries but may be prone to failure. The challenge arises when ICG staining fails, as it cannot be repeated during surgery.

Laparoscopic left hemihepatectomy using augmented reality navigation plus ICG fluorescence imaging for hepatolithiasis: a retrospective single-arm cohort study (with video).

Background: Laparoscopic left hemihepatectomy (LLH) has been shown to be an effective and safe method for treating hepatolithiasis primarily affecting the left hemiliver. However, this procedure still presents challenges. Due to pathological changes in intrahepatic duct stones, safely dissecting the hilar vessels and determining precise resection boundaries remains difficult, even with fluorescent imaging.

Modeling the light-powered self-rotation of a liquid crystal elastomer fiber-based engine.

Self-oscillating systems possess the ability to convert ambient energy directly into mechanical work, and new types of self-oscillating systems are worth designing for practical applications in energy harvesters, engines and actuators. Taking inspiration from the four-stroke engine. A concept for a self-rotating engine is presented on the basis of photothermally responsive materials, consisting of a liquid crystal elastomer (LCE) fiber, a hinge and a turnplate, which can self-rotate under steady illumination.

A light-powered self-rotating liquid crystal elastomer drill.

Self-oscillating systems can directly convert ambient energy to mechanical work, and new type self-oscillating systems are worth designing for applications in energy harvesters, engines, and actuators. Taking inspiration from the hand drill, we have developed a novel self-rotating drill system, which is consist of a turnplate and a liquid crystal elastomer (LCE) fiber under steady illumination. To investigate the self-rotating behaviors of the LCE drill, we have proposed a nonlinear theoretical model of the LCE drill under steady illumination based on the well-established dynamic LCE model.

DNA methylation heterogeneity attributable to a complex tumor immune microenvironment prompts prognostic risk in glioma.

Gliomas are malignant tumours of the human nervous system with different World Health Organization (WHO) classifications, glioblastoma (GBM) with higher grade and are more malignant than lower-grade glioma (LGG). To dissect how the DNA methylation heterogeneity in gliomas is influenced by the complex cellular composition of the tumour immune microenvironment, we first compared the DNA methylation profiles of purified human immune cells and bulk glioma tissue, stratifying three tumour immune microenvironmental subtypes for GBM and LGG samples from The Cancer Genome Atlas (TCGA). We found that more intermediate methylation sites were enriched in glioma tumour tissues, and used the Proportion of sites with Intermediate Methylation (PIM) to compare intertumoral DNA methylation heterogeneity.

Impact of three-dimensional reconstruction visualization technology on short-term and long-term outcomes after hepatectomy in patients with hepatocellular carcinoma: a propensity-score-matched and inverse probability of treatment-weighted multicenter study.

Background: Three-dimensional reconstruction visualization technology (3D-RVT) is an important tool in the preoperative assessment of patients undergoing liver resection. However, it is not clear whether this technique can improve short-term and long-term outcomes in patients with hepatocellular carcinoma (HCC) compared with two-dimensional (2D) imaging.

Method: A total of 3402 patients from five centers were consecutively enrolled from January 2016 to December 2020, and grouped based on the use of 3D-RVT or 2D imaging for preoperative assessment.

Unsupervised Fusion of Misaligned PAT and MRI Images via Mutually Reinforcing Cross-Modality Image Generation and Registration.

Photoacoustic tomography (PAT) and magnetic resonance imaging (MRI) are two advanced imaging techniques widely used in pre-clinical research. PAT has high optical contrast and deep imaging range but poor soft tissue contrast, whereas MRI provides excellent soft tissue information but poor temporal resolution. Despite recent advances in medical image fusion with pre-aligned multimodal data, PAT-MRI image fusion remains challenging due to misaligned images and spatial distortion.

CylinGCN: Cylindrical structures segmentation in 3D biomedical optical imaging by a contour-based graph convolutional network.

Cylindrical organs, e.g., blood vessels, airways, and intestines, are ubiquitous structures in biomedical optical imaging analysis.

Efficacy of Augmented Reality Combined with Indocyanine Green Fluorescence Imaging Guided Laparoscopic Segmentectomy for Hepatocellular Carcinoma.

Background: The internal anatomy of the liver is extremely complex. Laparoscopic anatomical segmentectomy requires reference to the position and alignment of intrahepatic vascular. However, the surface of the liver lacks anatomical landmarks and the liver segment boundaries cannot be identified with the naked eye.

A Light-Powered Liquid Crystal Elastomer Roller.

Achieving and controlling the desired movements of active machines is generally accomplished through precise control of artificial muscles in a distributed and serialized manner, which is a significant challenge. The emerging motion control strategy based on self-oscillation in active machines has unique advantages, including directly harvesting energy from constant ambient light, and it has no need for complex controllers. Inspired by the roller, we have innovatively developed a self-rolling roller that consists of a roller and a liquid crystal elastomer (LCE) fiber.

Symmetric Kondo Lattice States in Doped Strained Twisted Bilayer Graphene.

We use the topological heavy fermion (THF) model and its Kondo lattice (KL) formulation to study the possibility of a symmetric Kondo (SK) state in twisted bilayer graphene. Via a large-N approximation, we find a SK state in the KL model at fillings ν=0,±1,±2 where a KL model can be constructed. In the SK state, all symmetries are preserved and the local moments are Kondo screened by the conduction electrons.

Augmented Reality Navigation Plus Indocyanine Green Fluorescence Imaging Can Accurately Guide Laparoscopic Anatomical Segment 8 Resection.

Background: Laparoscopic anatomical Segment 8 (S8) resection is a highly challenging hepatectomy. Augmented reality navigation (ARN), which could be combined with indocyanine green (ICG) fluorescence imaging, has been applied in various complex liver resections and may also be applied in laparoscopic anatomical S8 resection. However, no study has explored how to apply ARN plus ICG fluorescence imaging (ARN-FI) in laparoscopic anatomical S8 resection, or explored its accuracy.

Kondo Lattice Model of Magic-Angle Twisted-Bilayer Graphene: Hund's Rule, Local-Moment Fluctuations, and Low-Energy Effective Theory.

We apply a generalized Schrieffer-Wolff transformation to the extended Anderson-like topological heavy fermion (THF) model for the magic-angle (θ=1.05°) twisted bilayer graphene (MATBLG) [Phys. Rev.

Coupled topological flat and wide bands: Quasiparticle formation and destruction.

Flat bands amplify correlation effects and are of extensive current interest. They provide a platform to explore both topology in correlated settings and correlation physics enriched by topology. Recent experiments in correlated kagome metals have found evidence for strange-metal behavior.

UMRFormer-net: a three-dimensional U-shaped pancreas segmentation method based on a double-layer bridged transformer network.

Background: Methods based on the combination of transformer and convolutional neural networks (CNNs) have achieved impressive results in the field of medical image segmentation. However, most of the recently proposed combination segmentation approaches simply treat transformers as auxiliary modules which help to extract long-range information and encode global context into convolutional representations, and there is a lack of investigation on how to optimally combine self-attention with convolution.

Methods: We designed a novel transformer block (MRFormer) that combines a multi-head self-attention layer and a residual depthwise convolutional block as the basic unit to deeply integrate both long-range and local spatial information.

Perioperative and Disease-Free Survival Outcomes after Hepatectomy for Centrally Located Hepatocellular Carcinoma Guided by Augmented Reality and Indocyanine Green Fluorescence Imaging: A Single-Center Experience.

Background: Laparoscopic hepatectomy for centrally located hepatocellular carcinoma is challenging to perform. Augmented reality navigation (ARN) and fluorescence imaging are currently safe and reproducible techniques for hepatectomy, but the efficacy results for centrally located hepatocellular carcinoma have not been reported. This study aimed to evaluate the efficacy of an ARN system combined with fluorescence imaging (ARN-FI) in laparoscopic hepatectomy for centrally located hepatocellular carcinoma.

How does mandatory energy conversion affect sustainable development: Perspectives of regional heterogeneity and efficiency decomposition.

Clean energy conversion is a core approach and development trend to tackle climate change, while the severe drawbacks such as supply deficiency and cost increase restrict regional sustainable development. This paper employs a natural experiment of coal-to-gas conversion of the Chinese government to study the effect of such policy on regional sustainable development, as well as the underlying mechanism. Based on a city-level dataset from 2006 to 2019, this paper measure green total factor productivity (GTFP) using data envelopment analysis (DEA) combined with the Malmquist‒Luenberger productivity index.

Revisiting the gravity laws of inter-city mobility in megacity regions.

Inter-city mobility is one of the most important issues in the UN Sustainable Development Goals, as it is essential to access the regional labour market, goods and services, and to constrain the spread of infectious diseases. Although the gravity model has been proved to be an effective model to describe mobility among settlements, knowledge is still insufficient in regions where dozens of megacities interact closely and over 100 million people reside. In addition, the existing knowledge is limited to overall population mobility, while the difference in inter-city travel with different purposes is unexplored on such a large geographic scale.