Rapid and automatic hemodynamic assessment: integration of deep learning-based image segmentation, vessel reconstruction, and CFD prediction.

Background: Currently, vascular hemodynamic analyses are typically conducted using commercial software. This process usually involves reconstructing the three-dimensional (3D) geometry of blood vessels, generating a computational mesh, and performing a computational fluid dynamics (CFD) analysis. It requires skilled medical personnel to manually process medical images, which is time consuming and prone to errors.

Identification and characterization of soybean phytochrome-interacting factors and their potential roles in abiotic stress.

Phytochrome-interacting factors (PIFs) belong to a subfamily of the bHLH transcription factor family and play a pivotal role in plant light signal transduction, hormone signal pathways, and the modulation of plant responses to various abiotic stresses. The soybean (Glycine max) is a significant food crop, providing essential oil and nutrients. Additionally, it is a vital industrial raw material and a lucrative cash crop.

An improved multi-scale feature extraction network for medical image segmentation.

Background: The use of U-Net and its variations has led to significant advancements in medical image segmentation. However, the encoder-decoder structures of these models often lose spatial information during downsampling. Skip connections can help address this issue; however, they may also introduce excessive irrelevant background information.

Comparison of survival, function and complication between intercalary frozen autograft versus massive allograft reconstruction after malignant bone tumors resection.

Purpose: This study aims to compare the clinical outcomes of intercalary frozen autograft and allograft reconstruction for primary malignant bone tumors.

Methods: A retrospective study was conducted on 144 patients who underwent intercalary biological reconstruction for primary malignant bone tumors at a single institution between January 2012 and July 2023. Seventy-two patients underwent intercalary liquid nitrogen-frozen autograft reconstruction, and 72 patients underwent intercalary allograft reconstruction in this study.

Strange Metal and Superconductor in the Two-Dimensional Yukawa-Sachdev-Ye-Kitaev Model.

The two-dimensional Yukawa-Sachdev-Ye-Kitaev (2D-YSYK) model provides a universal theory of quantum phase transitions in metals in the presence of quenched random spatial fluctuations in the local position of the quantum critical point. It has a Fermi surface coupled to a scalar field by spatially random Yukawa interactions. We present full numerical solutions of a self-consistent disorder averaged analysis of the 2D-YSYK model in both the normal and superconducting states, obtaining electronic spectral functions, frequency-dependent conductivity, and superfluid stiffness.

Injectable hydrogels for Fenton-like Mn/Fe delivery with enhanced chemodynamic therapy prevent osteosarcoma recurrence and promote wound healing after excision surgery.

Local recurrence of osteosarcoma and wound healing after excision surgery are major challenges in clinical research. The present anti-tumor treatments could inhibit normal tissues, resulting in difficulties in surgical wound healing. In this study, we constructed an injectable hydrogel as a platform to co-deliver MnO nanoparticles and ferrocene Fc, termed as (MnO/Fc)@PLGA for osteosarcoma treatment and wound healing after excision.

Uncovering seed vigor responsive miRNA in hybrid wheat and its parents by deep sequencing.

Background: Two-line hybrid wheat technology system is one way to harness wheat heterosis both domestically and internationally. Seed vigor is a crucial parameter for assessing seed quality, as enhanced seed vigor can lead to yield increments of over 20% to a certain extent. MicroRNAs (miRNAs) were known to participate in the development and vigor of seed in plants, but its impact on seed vigor in two-line hybrid wheat remains poorly elucidated.

Membrane-coated nanoparticles as a biomimetic targeted delivery system for tumour therapy.

Drug therapy towards tumours often causes adverse effects because of their non-specific nature. Membrane-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe delivery. By camouflaging the nanoparticles with natural derived or artificially modified cell membranes, the nano-payloads are bestowed with properties from cell membranes such as longer circulation, tumour or inflammation-targeting, immune stimulation, augmenting the performance of traditional therapeutics.

Constructing Quasi-Single Ion Conductors by a β-Cyclodextrin Polymer to Stabilize Zn Anode.

Aqueous Zn-ion batteries (AZIBs) are promising for the next-generation large-scale energy storage. However, the Zn anode remains facing challenges. Here, we report a cyclodextrin polymer (P-CD) to construct quasi-single ion conductor for coating and protecting Zn anodes.

Hybrid-Microstructure-Based Soft Network Materials with Independent Tunability of Mechanical Properties over Large Deformations.

Introducing auxetic metamaterials into stretchable electronics shows promising prospects for enhancing the performance and innovating the functionalities of various devices, such as stretchable strain sensors. Nevertheless, most existing auxetics fail to meet the requirement of stretchable electronics, which typically include high mechanical flexibility and stable Poisson's ratio over large deformations. Moreover, despite being highly advantageous for application in diverse load-bearing conditions, achieving tunability of J-shaped stress-strain response independent of negative Poisson's ratio remains a significant challenge.

Functional alterations in overweight/obesity: focusing on the reward and executive control network.

Overweight (OW) and obesity (OB) have become prevalent issues in the global public health arena. Serving as a prominent risk factor for various chronic diseases, overweight/obesity not only poses serious threats to people's physical and mental health but also imposes significant medical and economic burdens on society as a whole. In recent years, there has been a growing focus on basic scientific research dedicated to seeking the neural evidence underlying overweight/obesity, aiming to elucidate its causes and effects by revealing functional alterations in brain networks.

The association between the triglyceride-glucose index and in-stent restenosis in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.

Background: Insulin resistance (IR) can lead to cellular metabolic disorders, activation of oxidative stress, and endothelial dysfunction, contributing to in-stent restenosis (ISR). The triglyceride-glucose index (TyG index), a new indicator reflecting IR, is extensively researched in the cardiovascular field. This study, through a meta-analysis, aimed to utilize a larger combined sample size and thereby enhance the overall test efficacy to explore the TyG index-ISR relationship.

Hairless (Hr) Deficiency Mitigates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice.

Obesity is a significant global health concern linked to excessive dietary energy intake. This research focuses on the mammalian hairless protein (HR), known for its role in skin and hair function, and its impact on metabolism. Examining male wild-type (Hr) and Hr null (Hr) mice over a 14-week normal chow diet (NCD) or high-fat diet (HFD) intervention.

Neural 3D Scene Reconstruction With Indoor Planar Priors.

This paper addresses the challenge of reconstructing 3D indoor scenes from multi-view images. Many previous works have shown impressive reconstruction results on textured objects, but they still have difficulty in handling low-textured planar regions, which are common in indoor scenes. An approach to solving this issue is to incorporate planar constraints into the depth map estimation in multi-view stereo-based methods, but the per-view plane estimation and depth optimization lack both efficiency and multi-view consistency.

Iontronic Dynamic Sensor with Broad Bandwidth and Flat Frequency Response Using Controlled Preloading Strategy.

Rapid advancements in human-machine interaction and voice biometrics impose desirability on soft mechanical sensors for sensing complex dynamic signals. However, existing soft mechanical sensors mainly concern quasi-static signals such as pressure and pulsation for health monitoring, limiting their applications in emerging wearable electronics. Here, we propose a hydrogel-based soft mechanical sensor that enables recording a wide range of dynamic signals relevant to humans by combining a preloading design strategy and iontronic sensing mechanism.

Rbfox1 regulates alternative splicing of Nrcam in primary sensory neurons to mediate peripheral nerve injury-induced neuropathic pain.

The primary sensory neurons of the dorsal root ganglia (DRG) are subject to transcriptional alterations following peripheral nerve injury. These alterations are believed to play a pivotal role in the genesis of neuropathic pain. Alternative RNA splicing is a process that generates multiple transcript variants from a single gene, significantly contributing to the complexity of the transcriptome.

Practical organic batteries: Concepts to realize high mass loading with high performance.

Organic electrode materials (OEMs) have been well developed in recent years. However, the practical applications of OEMs have not been paid sufficient attention. The concept here focused on one of the essential aspects for practical applications, i.

Evaluation of starvation status in the early developmental stages of black rockfish (Sebastes schlegelii) based on morphological and histological characteristics.

Assessing the nutritional status and identifying major causes of mortality in larvae experiencing varying degrees of starvation are crucial for establishing appropriate feeding protocols and enhancing the welfare of hatchery-reared fish. The black rockfish Sebastes schlegelii is an important species in aquaculture and stock enhancement efforts in China, Japan, and Korea. This study aimed to identify optimal diagnostic morphometric indicators of starvation in newly hatched (0-6 days post-hatch, DPH) and postlarval stages (27-37 DPH) of this valuable fish species through histological analyses.