Fabrication of a novel macrophage-targeted biomimetic delivery composite hydrogel with multiple-sensitive properties for tri-modal combination therapy of rheumatoid arthritis.

In this study, a porous polydopamine (PDA) nanoparticle-decorated β-glucan microcapsules (GMs) nanoplatform (PDA/GMs) were developed with macrophage-targeted biomimetic features and a carriers-within-carriers structure. Indocyanine green (ICG) and catalase (CAT) were subsequently co-encapsulated within the PDA/GMs to create a multifunctional nanotherapeutic agent, termed CIPGs. Furthermore, CIPGs and sinomenine (SIN) were co-loaded within a thermo-sensitive hydrogel to design an injectable delivery system, termed CIPG/SH, with potential for multi-modal therapy of rheumatoid arthritis (RA).

Coupling Electro-Fenton and Electrocoagulation of Aluminum-Air Batteries for Enhanced Tetracycline Degradation: Improving Hydrogen Peroxide and Power Generation.

Electro-Fenton (EF) technology has shown great potential in environmental remediation. However, developing efficient heterogeneous EF catalysts and understanding the relevant reaction mechanisms for pollutant degradation remain challenging. We propose a new system that combines aluminum-air battery electrocoagulation (EC) with EF.

Optimum parameters for humic acid removal and power production by Al-air fuel cell electrocoagulation in synthetic wastewater.

Although humic acid (HA) is a complex natural organic matter, it can potentially harm the environment and human health. In this study, aluminum-air fuel cell electrocoagulation (AAFCEC) was used to remove HAs from water while generating electricity. Initial pH, electrolyte concentration, HA concentration electrode distance and external resistance were investigated to determine the power generation and removal efficiency.

The reinforcement of sludge-recycling enhanced flocculation by the acid activation of settled sludge.

Sludge-recycling enhanced flocculation (SEF) is an effective method for enhancing flocculation. In the conventional SEF process, the settled sludge is recirculated into the flocculation process without any further treatment. However, studies have shown that the efficacy of the SEF process could be improved by pre-treating the sludge.

Sensitive and Selective Measurement of Hydroxyl Radicals at Subcellular Level with Tungsten Nanoelectrodes.

Hydroxyl radical (OH) is an essential reactive oxygen species involved in critical cell functions. However, the mechanisms controlling its subcellular localization and intracellular level during health and disease remain poorly understood. This is due to the challenge of detecting OH that are highly reactive and consequently short-lived (in vivo half-life of ∼10 s).