Late-Stage Pd(II)-Catalyzed C(sp3)-H Functionalization of Peptides Directed by a Removable, Backbone-Inserted Amidoxime Ether.

Palladium(II)-catalyzed C-H functionalization has attracted considerable attention as a pathway to late-stage modification of peptides. Herein, we report the Pd-catalyzed C(sp3)-H arylation of peptides directed by an amidoxime ether, which can be easily incorporated into peptides at any amide bond. Site- and stereoselective arylation of peptides has been achieved, including an unprecedented example of C-H arylation of an internal residue.

Blockchain Technology, Cryptocurrency: Entropy-Based Perspective.

The large-scale application of blockchain technology is an expected to be an inevitable trend. This study revolves around published papers and articles related to blockchain technology, relevance analysis and sorting through the retrieved documents with six core layers of blockchain: Application Layer, Contract Layer, Actuator Layer, Consensus Layer, Network Layer and Data Layer. Based on the analysis results, this study found that China's research is more towards the preference and application of landing and industry and smart cities with blockchain as the underlying technology.