Publications by authors named "Haoxuan Li"

The treatment of ammonia nitrogen wastewater (ANW) has garnered significant attention due to the ecology, and even biology is under increasing threat from over discharge ANW. Conventional ANW treatment methods often encounter challenges such as complex processes, high costs and secondary pollution. Considerable progress has been made in employing solar-induced evaporators for wastewater treatment.

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Diabetes poses a considerable global health challenge, with varying levels of diabetes knowledge among healthcare professionals, highlighting the importance of diabetes training. Large Language Models (LLMs) provide new insights into diabetes training, but their performance in diabetes-related queries remains uncertain, especially outside the English language like Chinese. We first evaluated the performance of ten LLMs: ChatGPT-3.

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Due to the monogamous mating system and late maturity of pigeons, their breeding cycle is longer compared to that of other poultry species, which has hindered the optimization of growth traits and meat quality. While traditional breeding methods are commonly used, they lack precision and are time-consuming. This study integrates phenotypic data from Tarim pigeons and White King pigeons with genomic information, using genome-wide association analysis (GWAS) to identify genetic markers associated with key economic traits, thereby accelerating the breeding process.

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Background: Postoperative venous thromboembolism (VTE) following hip arthroscopy is associated with increased hospital readmissions and significant medical costs. However, the risk factors for postoperative VTE after hip arthroscopy remain a topic of debate. In this study, we aimed to quantitatively and comprehensively identify risk factors for postoperative VTE after hip arthroscopy, providing evidence for the development of clinical prevention strategies.

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Introduction: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is one of the most common etiologies of acute pancreatitis (AP) worldwide. Compared with other etiologies, patients with HTG-AP may develop more severe AP, but previous studies yielded controversial conclusion due to the lack of adequate adjustment for the confounders. Therefore, the aim of this study was to examine the possibility and risk factors of developing severe AP in HTG-AP.

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Hydrogen peroxide (HO) is a ubiquitous signal regulating many biological processes, including innate immunity, in all eukaryotes. However, it remains largely unknown that how transcription factors directly sense HO in eukaryotes. Here, we report that rice basic/helix-loop-helix transcription factor bHLH25 directly senses HO to confer resistance to multiple diseases caused by fungi or bacteria.

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Pseudouridine (Ψ) is the most abundant RNA modification, yet studies of Ψ have been hindered by a lack of robust methods to profile comprehensive Ψ maps. Here we utilize bisulfite-induced deletion sequencing to generate transcriptome-wide Ψ maps at single-base resolution across various plant species. Integrating ribosomal RNA, transfer RNA and messenger RNA Ψ stoichiometry with mRNA abundance and polysome profiling data, we uncover a multilayered regulation of translation efficiency through Ψ modifications.

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Image-based spatial transcriptomic sequencing technologies have enabled the measurement of gene expression at single-cell resolution, but with a limited number of genes. Current computational approaches attempt to overcome these limitations by imputing missing genes, but face challenges regarding prediction accuracy and identification of cell populations due to the neglect of gene-gene relationships. In this context, we present stImpute, a method to impute spatial transcriptomics according to reference scRNA-seq data based on the gene network constructed from the protein language model ESM-2.

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Article Synopsis
  • This study investigates the mechanisms behind acute lung injury (ALI) caused by diseases, focusing on the AMPK/Nrf2 pathway as a potential therapeutic target.
  • Using a mouse model and treatments like Dimethyl fumarate (DMF), the study found that activation of AMPK/Nrf2 reduced oxidative stress and inflammation caused by LPS, improving lung injury scores.
  • Results indicated that LPS increased harmful reactive oxygen species (ROS) and inflammatory markers, but DMF treatment countered these effects, suggesting the AMPK/Nrf2 pathway could be a viable target for ALI therapies.
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Traditional kinesiology tape (KT) is an elastic fabric tape that clinicians and sports trainers widely use for managing ankle sprains. However, inadequate mechanical properties, adhesive strength, water resistance, and micro-damage generation could affect the longevity of the tape on the skin during physical activity and sweating. Therefore, autonomous room-temperature self-healing elastomers with robust mechanical properties and adequate adhesion to the skin are highly desirable to replace traditional KT.

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This study aimed to investigate the effects of dietary riboflavin levels on the reproductive performance of pigeon breeders and the growth performance and carcass traits of offspring squabs to estimate the riboflavin requirement of pigeon breeders. The natural riboflavin content in the basic diet of corn-peas-soybean-wheat-sorghum-corn gluten is 1.20 mg/kg.

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Article Synopsis
  • Deep-learning techniques are crucial in pansharpening to enhance the spatial resolution of multispectral images using panchromatic images while preserving spectral features.
  • Many existing methods struggle with unknown or different degradations in testing data, often leading to poor performance in practical situations.
  • The proposed VBPN deep variational network effectively combines degradation estimation and image fusion in a Bayesian framework, improving blind pansharpening results and demonstrating superior performance in experiments.
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Background: The novel coronavirus disease 2019 as the most pervasive and consequential pandemic in recent years, has exerted significant impacts on human health, including aspects related to body weight. Objectives: This study aims to assess the influence of the lockdown measures implemented during the COVID-19 pandemic on Chinese college students' Body Mass Index (BMI) through a three-year cohort study.

Methods: We recruited 6156 college students (n = 4,248, 69% male, and n = 1,908, 31% female, with an average age of 18.

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Article Synopsis
  • - The study investigated thermophilic anaerobic digestion (AD) of chicken manure, focusing on how the process can handle high ammonia levels over 450 days, revealing a decrease in methane production as total solids increased.
  • - After a feeding stoppage, the reactor was able to recover, indicating the potential for resilience in methane generation, with significant shifts in microbial community gene expression linked to the methane production pathway.
  • - Findings highlight Halocella sp. as a key microorganism that may improve the efficiency of AD by facilitating the conversion of acetate to methane, setting a foundation for future research on managing high nitrogen content in poultry manure.
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Polylactide/ethylene vinyl alcohol copolymer (PLA/EVOH) blends and fibers with different weight ratios were prepared by melt blending, and two-step melt spinning, respectively. PLA and EVOH in PLA/EVOH blends were immiscible. When EVOH content was ≤60 %, EVOH with the average diameter of about 3 μm was dispersed in PLA matrix uniformly.

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Imaging plates can measure isotopes with alpha decay (such as radon and its progeny, americium, and so on). However, the detection efficiency of imaging plates is affected by alpha particle energy, types of imaging plates, and the overlapping effect. In this study, simulations were performed to analyze the relationship between detection efficiency and these three influence factors.

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N-methyladenosine (mA) plays critical roles in regulating mRNA metabolism. However, comprehensive mA methylomes in different plant tissues with single-base precision have yet to be reported. Here, we present transcriptome-wide mA maps at single-base resolution in different tissues of rice and Arabidopsis using mA-SAC-seq.

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With the fast development of new science and technology, wearable devices are in great demand in modern human daily life. However, the energy problem is a long-lasting issue to achieve real smart, wearable, and portable devices. Flexible thermoelectric generators (TEGs) based on thermoelectric conversion systems can convert body waste heat into electricity with excellent flexibility and wearability, which shows a new direction to solving this issue.

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Background: Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population.

Objective: This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD.

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Article Synopsis
  • Researchers created polylactide/chlorogenic acid (PLA/CGA) blends with different ratios through melt mixing and produced fibers via a two-step spinning process.
  • The addition of CGA resulted in a uniform distribution within the PLA matrix, lowering viscosity and crystallinity while slightly reducing the tensile strength of the fibers compared to neat PLA.
  • Notably, the PLA/CGA fibers demonstrated significant UV resistance and antioxidant properties, with the highest antioxidant rate exceeding 90% for blends containing 10% CGA.
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This study aimed to assess the effectiveness and safety of robot-assisted versus fluoroscopy-assisted pedicle screw implantation in scoliosis surgery. The study was registered in the PROSPERO (CRD42023471837). Two independent researchers searched PubMed, Web of Science, Cochrane Library, and China National Knowledge Infrastructure.

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The nuclear radiation imaging technology, aimed at illustrating the position and distribution of radioactive sources, has undergone extensive research. By relying on a simulated radiation imaging system for data acquisition, we can significantly expedite the development cycle of these imaging instruments. Establishing simulated experimental scenarios and radiation imaging systems is of paramount significance in obtaining output signals for algorithmic testing and validation.

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Article Synopsis
  • Robot-assisted cortical bone trajectory (RA-CBT) technology shows safety and effectiveness in spinal surgery, outperforming fluoroscopy-assisted (FA) methods in key surgical parameters.
  • A meta-analysis of six studies with 371 patients found RA-CBT had better accuracy in screw positioning and reduced complications like joint violations and neurological injuries.
  • The research highlights the need for further exploration of RA-CBT's efficacy in clinical practice, emphasizing its statistical significance in improving surgical outcomes.
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Photodynamic therapy (PDT) represents an emerging noninvasive treatment technique for cancers and various nonmalignant diseases, including infections. During the process of PDT, the physical and chemical properties of photosensitizers (PSs) critically determine the effectiveness of PDT. Traditional PSs have made great progress in clinical applications.

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