An internally validated prognostic nomogram model predicts the stone-free rate following endoscopic combined intrarenal surgery for renal stones.

Background: Here, we aim to develop and validate a viable prognostic nomogram model for predicting a stone-free rate of kidney stones patients based on retrospective cohort analysis.

Methods: This is a retrospective study that obtained a continuous cohort from the databases of two hospitals (General Hospital of Southern Theater Command, and Guangdong Second Provincial General Hospital), including 522 patients with kidney stones who underwent Endoscopic Combined Intrarenal Surgery (ECIRS) from January 2015 to December 2022.The characteristics of the primary cohort between the SF (stone-free) and SR (stone residue) groups were identified using single factor and multivariate logistic regression analyses.

Dysplastic ganglion cell tumor of the right cerebellum: A case report and literature review.

Rationale: This study aims to present a case of cerebellar dysplastic ganglioneuroma, which is commonly referred to as Lhermitte-Duclos disease (LDD). Furthermore, the study aims to provide an extensive review of the essential aspects of LDD, thereby providing essential information for its accurate diagnosis and effective treatment.

Patient Concerns: A 54-year-old woman was admitted with symptoms of headache, facial numbness, and a visible cerebellar mass.

Size-dependent catalytic activity for CO oxidation over sub-nano-Au clusters.

Gold (Au) nanocatalysts present outstanding activity for many reactions and have long attracted much attention, but the size effect of sub-nano-clusters on catalytic activity lacks systematic research. Using CO oxidation as a probe reaction, the size-dependent catalytic capability of sub-nano-Au clusters was explored. The global-minimum (GM) structures of Au ( = 2-300, <2.

Thermal Effect Management via Entropy Variation Strategy to Improve the Catalyst Stability in Acetylene Hydrogenation.

The dynamic structure evolution of heterogeneous catalysts during reaction has gained great attention recently. However, controllably manipulating dynamic process and then feeding back catalyst design to extend the lifetime remains challenging. Herein, we proposed an entropy variation strategy to develop a dynamic CuZn-Co/HEOs catalyst, in which the non-active Co nano-islands play a crucial role in controlling thermal effect via timely capturing and utilizing reaction heat generated on the adjacent active CuZn alloys, thus solving the deactivation problem of Cu-based catalysts.

Infliximab inhibits TNF-α-dependent activation of the NLRP3/IL-1β pathway in acne inversa.

Background: Acne inversa (AI) is a refractory inflammatory skin disease, and TNF-α plays an important role in the pathogenesis of AI. By blocking TNF-α, infliximab (IFX) has been proven to be a promising method.

Objectives: To explore the underlying mechanisms of IFX treatment in AI patients.

Nomogram including renal pelvic pressure to predict the occurrence of urosepsis following percutaneous nephrolithotomy: a dual center retrospective study of 1,448 patients.

Background: Urosepsis is a serious complication after percutaneous nephrolithotomy (PCNL). This study aimed to develop and validate a nomogram model that can effectively predict urosepsis following PCNL.

Methods: A total of 839 patients who underwent PCNL at General Hospital of Southern Theater Command from January 2018 to January 2023 and a total of 609 patients who underwent PCNL at Guangdong Second Provincial General Hospital from January 2020 to January 2023 were retrospectively analyzed in this study.

CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway.

Background: White matter injury (WMI) represents a significant etiological factor contributing to neurological impairment subsequent to Traumatic Brain Injury (TBI). CD36 receptors are recognized as pivotal participants in the pathogenesis of neurological disorders, including stroke and spinal cord injury. Furthermore, dynamic fluctuations in the phenotypic polarization of microglial cells have been intimately associated with the regenerative processes within the injured tissue following TBI.

A General Descriptor for Single-Atom Catalysts with Axial Ligands.

Decoration of an axial coordination ligand (ACL) on the active metal site is a highly effective and versatile strategy to tune activity of single-atom catalysts (SACs). However, the regulation mechanism of ACLs on SACs is still incompletely known. Herein, we investigate diversified combinations of ACL-SACs, including all 3d-5d transition metals and ten prototype ACLs.

Functional evaluation of PF9 for its potential in controlling enterotoxigenic in weaned piglets.

During the bacterial selection, isolate PF9 demonstrated tolerance to low pH and high bile salt and an ability to extend the lifespan of infected with enterotoxigenic (;  < 0.05). Thirty-two weaned piglets susceptible to ETEC F4 were randomly allocated to four treatments as follows: 1) non-challenged negative control group (; basal diet and piglets gavaged with phosphate-buffered saline), 2) negative control group (; basal diet and piglets challenged with ETEC F4, 3 × 10 CFU per pig), 3) positive control (; basal diet + 80 mg·kg of avilamycin and piglets challenged with ETEC F4), and 4) probiotic candidate (PF9; control basal diet + 2.

Discovery of Alloy Catalysts Beyond Pd for Selective Hydrogenation of Reformate via First-Principle Screening with Consideration of H-Coverage.

The highly selective hydrogenation to remove olefins is a significant refining approach for the reformate. Herein, a library of transition metal for reformate hydrogenation is tested experimentally to validate the predictive level of catalytic activity from our theoretical framework, which combines ab initio calculations and microkinetic modeling, with consideration of surface H-coverage effect on hydrogenation kinetics. The favorable H coverage of specific alloy surface under relevant hydrogenation condition, is found to be determined by its corresponding alloy composition.

Regulation of oxidative stress in the intestine of piglets after enterotoxigenic Escherichia coli (ETEC) infection.

Enterotoxigenic Escherichia coli (ETEC) is recognized globally as a major gastrointestinal pathogen that impairs intestinal function. ETEC infection can lead to oxidative stress and disruption of intestinal integrity. The present study investigated the mechanism of increased oxidative stress and whether restoration of antioxidant defense could improve intestinal integrity in a piglet model with ETEC infection.

Loratidine is associated with improved prognosis and exerts antineoplastic effects via apoptotic and pyroptotic crosstalk in lung cancer.

Background: Tumor-associated inflammation suggests that anti-inflammatory medication could be beneficial in cancer therapy. Loratadine, an antihistamine, has demonstrated improved survival in certain cancers. However, the anticancer mechanisms of loratadine in lung cancer remain unclear.

Hsa_circ_0105040 promotes Cutbacterium acnes biofilm induced inflammation via sponge miR-146a in human keratinocyte.

Acne is a chronic inflammatory skin disease, and the pathogenesis of acne induced by Cutibacterium acnes (C.acnes) is not well understood. Recently, circular RNAs (circRNAs) have attracted much attention because of its involvement in various diseases.

Utilizing the photodynamic properties of curcumin to disrupt biofilms in Cutibacterium acnes: A promising approach for treating acne.

Background: The treatment of acne vulgaris is often challenging due to the antibiotic resistance frequently observed in Cutibacterium acnes (C.acnes), a prevalent bacterium linked to this condition.

Objective: The objective of this research was to examine the impact of curcumin photodynamic therapy (PDT) on the survival of C.

Understanding the Pathway Switch of the Oxygen Reduction Reaction from Single- to Double-/Triple-Atom Catalysts: A Dual Channel for Electron Acceptance-Backdonation.

Recently, a lot of attention has been dedicated to double- or triple-atom catalysts (DACs/TACs) as promising alternatives to platinum-based catalysts for the oxygen reduction reaction (ORR) in fuel cell applications. However, the ORR activity of DACs/TACs is usually theoretically understood or predicted using the single-site association pathway (O → OOH* → O* → OH* → HO) proposed from Pt-based alloy and single-atom catalysts (SACs). Here, we investigate the ORR process on a series of graphene-supported Fe-Co DACs/TACs by means of first-principles calculation and an electrode microkinetic model.

Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study.

Using Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichment analyses of single nucleotide polymorphisms (SNPs) associated with cancer allowed for a comprehensive bioinformatics approach, which offered a deeper biological understanding of these relationships. The results indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer. Conversely, increased testosterone was linked to lower stomach cancer risk for men, whereas high SHBG levels were related to decreased risks of breast and prostate cancers.

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis.

Introduction: CircRNAs are closely related to many human diseases; however, their role in acne remains unclear. This study aimed to determine the role of hsa_circ_0102678 in regulating inflammation of acne.

Methods: First, microarray analysis was performed to study the expression of circRNAs in acne.

Novel 2D carbon material T-graphene supported 3d transition metal single atoms as efficient oxygen reduction catalysts.

Carbon-based support anchored 3d transition metal (TM) single atom catalysts (SACs) have been widely considered as promising candidates for the oxygen reduction reaction (ORR), and their intrinsic activity is closely related to the geometric and electronic structures of the supports. T-graphene was predicted to have high conductivity and stability, so it may be also a promising support for loading SACs for electrocatalysis. Here, we systematically evaluate the ORR activity of T-graphene supported TM single atoms (TMN-Tgra and TMC-Tgra, TM = Sc-Zn) and their graphene supported counterparts (TMN-Gra and TMC-Gra).