Leveraging spatial multiomics to unravel tissue architecture in embryo development.

Spatial multiomics technologies have revolutionized biomedical research by enabling the simultaneous measurement of multiple omics modalities within intact tissue sections. This approach facilitates the reconstruction of 3D molecular architectures, providing unprecedented insights into complex cellular interactions and the intricate organization of biological systems, such as those underlying embryonic development.

Non-volatile 2 × 2 optical switch using multimode interference in an SbSe-loaded waveguide.

We propose a non-volatile 2 × 2 photonic switch based on multimode interference in an SbSe-loaded waveguide. The different modal symmetries of the TE and TE modes supported in the multimode region change their propagation constants distinctly upon the SbSe phase transition. Through careful optical design and FDTD optimization of the multimode waveguide dimensions, efficient switching is achieved despite the modest index contrast of SbSe relative to GeSbTe.

High-Q chalcogenide racetrack resonators based on the multimode waveguide.

We propose and demonstrate a high quality (Q) factor racetrack resonator based on uniform multimode waveguides in high-index contrast chalcogenide glass film. Our design features two carefully designed multimode waveguide bends based on modified Euler curves, which enable a compact 180° bend and reduce the chip footprint. A multimode straight waveguide directional coupler is utilized to couple the fundamental mode without exciting higher-order modes in the racetrack.

Molecular Characterization of from Beef Cattle in Northeastern China.

is a common unicellular protist that lives in the intestines of humans and animals. infection and subtypes in cattle have been reported in several regions. However, the information of infection in cattle in China is still largely scant.

Integrating Network Pharmacology and Experimental Validation Deciphers the Mechanism of Guizhi Fuling Wan against Adenomyosis.

Aim: This study aimed to predict the key targets and endocrine mechanisms of Guizhi Fuling Wan (GZFLW) in treating adenomyosis (AM) through network pharmacology, molecular docking, and animal experiment verification.

Methods: The related ingredients and targets of GZFLW in treating AM were screened out using TCMSP, BATMAN-TCM, SwissTargetPrediction, and PubChem Database. Then, the protein-protein interaction (PPI) analysis and the network of compound-hub targets were constructed.

Detection of Point Prevalence and Assemblages of spp. in Dairy Calves and Sika Deer, Northeast China.

(syn ) is an important protozoan parasite that can cause enterocyte damage and loss of brush border of the epithelial cells in the intestine, resulting in shortening of microvilli and altered epithelial barrier function. Many animals have been detected as the hosts of the . However, the information on the epidemiology and molecular detection of in dairy calves and sika deer in northeastern China is limited.

Utilizing network pharmacology and molecular docking to explore the underlying mechanism of Guizhi Fuling Wan in treating endometriosis.

Background: Guizhi Fuling Wan (GZFLW) is a widely used classical Chinese herbal formulae prescribed for the treatment of endometriosis (EMs). This study aimed to predict the key targets and mechanisms of GZFLW in the treatment of EMs by network pharmacology and molecular docking.

Methods: Firstly, related compounds and targets of GZFLW were identified through the TCMSP, BATMAN-TCM and CASC database.

An extended hierarchical ordered probit model robust to heteroskedastic vignette perceptions with an application to functional limitation assessment.

To improve interpersonal comparability of self-reported measures, anchoring vignettes are increasingly collected in surveys and modeled as the hierarchical ordered probit (HOPIT) model. This paper-based on the idea of psychological distance-relaxes the assumption of vignette equivalence in the HOPIT by allowing for heteroscedasticity in respondents' perceptions of vignettes. Particularly, we assume that respondents who are more similar to a vignette are more familiar with the condition described and therefore are capable of forming a more precise perception of the vignette.

Geochemical behavior and potential health risk of heavy metals in basalt-derived agricultural soil and crops: A case study from Xuyi County, eastern China.

Basalt-derived agricultural soil is widely distributed around the world and is extensively used as a medium to plant many kinds of crops. Weathering of basalt can release heavy metals into the soils and may cause health risks via the food chain. However, the geochemical behavior and the potential human health risks of heavy metals remain poorly understood in these agro-systems.

Brucellosis seroprevalence in dairy cattle in China during 2008-2018: A systematic review and meta-analysis.

Brucellosis remains one of the most common zoonotic diseases globally with more than a half million human cases reported annually. The Brucella reservoir associated with livestock brucellosis poses a significant threat to public health, and awareness of the seroprevalence and spatial distribution of livestock brucellosis is valuable for the prevention and control of diseases caused by Brucella, especially human brucellosis. Therefore, we conducted a systematic review and meta-analysis to evaluate the seroprevalence of brucellosis in dairy cattle in China.

Dynamic Friction Performance of a Pneumatic Cylinder with Al2O3 Film on Cylinder Surface.

A friction force system is proposed for accurately measuring friction force and motion properties produced by reciprocating motion of piston in a pneumatic cylinder. In this study, the proposed system is used to measure the effects of lubricating greases of different viscosities on the friction properties of pneumatic cylinder, and improvement of stick-slip motion for the cylinder bore by anodizing processes. A servo motor-driven ball screw is used to drive the pneumatic cylinder to be tested and to measure the change in friction force of the pneumatic cylinder.