Identification of Potential lncRNA-miRNA-mRNA Regulatory Network Contributing to Arrhythmogenic Right Ventricular Cardiomyopathy.

Arrhythmogenic right ventricular cardiomyopathy (ARVC) can lead to sudden cardiac death and life-threatening heart failure. Due to its high fatality rate and limited therapies, the pathogenesis and diagnosis biomarker of ARVC needs to be explored urgently. This study aimed to explore the lncRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) network in ARVC.

Circulating trimethylamine N-oxide is correlated with high coronary artery atherosclerotic burden in individuals with newly diagnosed coronary heart disease.

Background: Trimethylamine N-oxide (TMAO) is a metabolite derived from the gut microbiota and has been reported to be correlated with cardiovascular diseases. Although TMAO is associated with the severity of coronary artery disease in subjects with coronary heart disease (CHD) history. However, the correlation between TMAO and the atherosclerotic burden in newly diagnosed cases of CHD is unknown.

PM2.5 associates with blood pressure: a Mendelian randomization analysis.

The relationship between fine particulate matter (PM2.5) and blood pressure (BP) is a controversial issue. We conducted a two-sample Mendelian randomization (MR) analysis and identified 58 genome-wide significant single-nucleotide polymorphisms associated with PM2.

In Situ Polymerization Derived from PAN-Based Porous Membrane Realizing Double-Stabilized Interface and High Ionic Conductivity for Lithium-Metal Batteries.

Polymer polyacrylonitrile (PAN), with exceptional mechanical strength and ionic conductivity, is considered a potential electrolyte. However, the huge interfacial impedance of PAN-derived C≡N polar nitrile groups and Li anode limited its application. In this study, a double-stabilized interface was integrated by in situ polymerization of DOL between electrodes and a three-dimensional (3D) porous PAN polymer matrix containing SN plasticizer and LLZTO ceramic fillers to optimize the challenge of interfacial instability.

Heterogeneous nucleation induced A. pernyi/B. mori silk fibroin coatings on AZ31 biometals with enhanced corrosion resistance, adhesion and biocompatibility.

Silk fibroin coatings on biomedical magnesium alloys have garnered significant attention due to their enhanced corrosion resistance and biocompatibility. However, the utilization of wild A. pernyi silk fibroin, known for its RGD sequence that facilitates tissue regeneration, presents a challenge for corrosion-resistant coatings on magnesium alloys due to its weak adhesion and high dissolution rate.

Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair.

Background: The adult mammalian heart is incapable of regeneration, whereas a transient regenerative capacity is maintained in the neonatal heart, primarily through the proliferation of preexisting cardiomyocytes. Neonatal heart regeneration after myocardial injury is accompanied by an expansion of cardiac fibroblasts and compositional changes in the extracellular matrix. Whether and how these changes influence cardiomyocyte proliferation and heart regeneration remains to be investigated.

In Situ Gelation of a 1,3-Dioxolane Dual-Permeable Porous Tandem Framework with Excellent Interfacial Stability to Power Long-Cycling Solid-State Lithium Metal Batteries.

Ceramic LiAlTi(PO) (LATP) with high ionic conductivity and stability in ambient atmosphere is considered to be potent as a solid-state electrolyte of solid-state lithium metal batteries (SSLMBs), but its huge interfacial impedance with electrodes and the unwanted Ti-mediated reduction reaction caused by the lithium (Li) metal anode greatly limit its application in LMBs. Herein, a composite polymer electrolyte (CPET) was integrated by in situ gelation of dual-permeable 1, 3-dioxolane (DOL) in the tandem framework composed of the commercial cellulose membrane TF4030 and a porous three-dimensional (3D) skeleton-structured LATP. The in situ gelled DOL anchored in the tandem framework ensured nice interfacial contact between the as-prepared CPET and electrodes.

Rapid warning of emerging contaminants in reuse water using biocathode sensors.

The proliferation of emerging contaminants (ECs) in the environment poses a major threat to the safety of reuse water. However, many ECs exist for which no corresponding control standards have been established. Here, we used polarity reversal to construct a biocathode sensor capable of early warning of ECs biotoxicity in aerobic reuse water with low organic concentrations.

Relationship between daytime napping and cardiovascular disease: A two-sample mendelian randomization study.

Objective: Daytime napping has been reported to have a potential association with an increased risk of cardiovascular diseases (CVDs) in several cohort studies, but the causal effects are unclear. In this study, we aimed to investigate the relationship between daytime napping and CVDs, as well as to validate causality in this relationship by Mendelian randomization (MR).

Methods: A two-sample MR method was used to evaluate the causal effect of daytime napping on CVDs.

Full Life-Cycle Lead Management and Recycling Transparent Conductors for Low-Cost Perovskite Solar Cell.

Realizing a full life-cycle management for toxic lead (Pb) and reducing material/manufacture cost are the key steps in determining the commercialization process of perovskite photovoltaics. In this work, we develop full lifecycle material management for a carbon-based perovskite solar cell (C-PSC) to immobilize and recover Pb against environmental pollution, followed by refabrication of C-PSC based on recovered materials and recycled transparent conductors from obsolete devices. Pb immobilization is first achieved by a strong coordination interaction between undercoordinated Pb ions from perovskite and a C═O bond from green pseudohalide ions (pseudo-X), and the resulting C-PSC with the structure of ITO/SnO/pseudo-X-perovskite/carbon yields an efficiency of 16.

Identification of potential lncRNA-miRNA-mRNA regulatory network contributing to aldosterone-producing adenoma.

Aldosterone-producing adenoma (APA) is a common cause of secondary hypertension. This study aimed to explore the lncRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) network to uncover molecular mechanism underlying APA. The mRNA and lncRNA expression data of APA and adjacent adrenal gland (AAG) from GSE60044, GSE64957 and GSE101894 were obtained from the Gene Expression Omnibus (GEO) database to analyse differentially expressed genes (DEGs) and lncRNAs (DElncs).

The Study of Mechanical Behaviors of Horn Sheath under Pendulum Impact.

As a light-weight natural keratin biocomposite, horn exhibits high mechanical properties and energy absorption. Different to the widely studied horn from subfamily and , few studies have focused on the horn sheath of subfamily . In this work, three horn sheathes from Cashmere goat, White goat and Black sheep were selected.

Optimized Langendorff perfusion system for cardiomyocyte isolation in adult mouse heart.

With the rapid development of single-cell sequencing technology, the Langendorff perfusion system has emerged as a common approach to decompose cardiac tissue and obtain living cardiomyocytes to study cardiovascular disease with the mechanism of cardiomyocyte biology. However, the traditional Langendorff perfusion system is difficult to master, and further, the viability and purity of cardiomyocytes are frequently unable to meet sequencing requirements due to complicated devices and manipulate processes. Here, we provide an optimized Langendorff perfusion system with a simplified and standardized operating protocol which utilizes gravity as the perfusion pressure, includes a novel method for bubbles removing and standardizes the criteria for termination of digestion.

gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration.

Background: A key cause of the high mortality of cardiovascular diseases is the cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement functional myocytes for cardiac repair, there is a pressing need to understand the cellular and molecular mechanisms of heart regeneration.

Methods: Seven genetic mouse lines were used: global OSM (oncostatin M) knockout, monocyte-/macrophage-specific OSM deletion, cardiomyocyte-specific lines, including OSM receptor deletion, gp130 (glycoprotein 130) deletion, gp130 activation, and Yap (yes-associated protein) ablation with gp130 activation mice.

Extracellular matrix-based biomaterials for cardiac regeneration and repair.

The spectrum of ischemic heart diseases, encompassing acute myocardial infarction to heart failure, represents the leading cause of death worldwide. Although extensive progress in cardiovascular diagnoses and therapy has been made, the prevalence of the disease continues to increase. Cardiac regeneration has a promising perspective for the therapy of heart failure.

The microfabrication of mold for polymer microfluidic devices with Zr-based metallic glass.

Polymer microfluidic devices are used for many purposes such as microarrays and biochips. The key tool for manufacturing these chips in bulk is an appropriate mold. However, the popular material for making molds is nickel or nickel alloys, which have low stiffness and wear out easily.