Publications by authors named "Haotian Fu"
Article Synopsis
- Despite advancements in machine learning, current systems struggle with real-world variability, requiring adaptation to new conditions and tasks.
- A proposed solution is "Lifelong Learning" systems that emphasize Continuous Learning, Transfer and Adaptation, and Scalability, yet research often treats these capabilities separately.
- The authors advocate for a holistic evaluation framework using a comprehensive set of metrics to assess the development of Lifelong Learning systems, demonstrating how these metrics can identify performance trade-offs and guide future research efforts.
Discoveries in Pancreatic Physiology and Disease Biology Using Single-Cell RNA Sequencing.
Front Cell Dev Biol
January 2022
Transcriptome analysis is used to study gene expression in human tissues. It can promote the discovery of new therapeutic targets for related diseases by characterizing the endocrine function of pancreatic physiology and pathology, as well as the gene expression of pancreatic tumors. Compared to whole-tissue RNA sequencing, single-cell RNA sequencing (scRNA-seq) can detect transcriptional activity within a single cell.
View Article and Find Full Text PDFPancreatic cancer is the fourth leading cause of cancer-related death with the characteristics of chemoresistance and early metastasis. Panaxadiol, a triterpenoid saponin extracted from the roots of American ginseng, has been proved to display anti-tumor activity in colon cancer. In this study, we found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.
View Article and Find Full Text PDFBackground: Pancreatic carcinoma is a malignant tumor with a high fatality rate, and the increased resistance of pancreatic carcinoma to chemotherapy has become a difficult problem in clinical practice. Hence, it is imperative to develop an effective treatment for pancreatic cancer. Sestrins are a class of stress-induced proteins that have antioxidation functions, regulating cell growth and metabolism.
View Article and Find Full Text PDFMany studies reported that Oxidative stress-responsive 1(OXSR1) is closely related to the malignant progression of several malignancies. Nevertheless, the expression pattern and function of OXSR1 in HCC remains unknown. In present research, it was observed that the expression of OXSR1 was abnormally elevated in HCC.
View Article and Find Full Text PDF