Exosomes from human induced pluripotent stem cells derived mesenchymal stem cells improved myocardial injury caused by severe acute pancreatitis through activating Akt/Nrf2/HO-1 axis.

Human induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) have been believed to be a promising alternative for the stem cell transplantation therapy. The exosomes (Exo) from iMSCs play an important role in several kinds of life activities. The role of exosomes from iMSCs in severe acute pancreatitis (SAP) induced myocardial injury (MI) has not been investigated.

[Clinical study on intravenous combined with aerosol inhalation of polymyxin B for the treatment of pneumonia caused by multidrug-resistant Gram-negative bacteria].

Objective: To investigate the efficacy of intravenous combined with aerosol inhalation of polymyxin B for the treatment of pneumonia caused by multidrug-resistant Gram-negative (G) bacteria.

Methods: A observational study was conducted. The clinical data of 45 patients with pneumonia due to multidrug-resistant G bacteria admitted to intensive care unit of Fujian Medical University Union Hospital from January to October in 2020 were analyzed.

MicroRNA-127-5p attenuates severe pneumonia via tumor necrosis factor receptor-associated factor 1.

Pneumonia is a persistent and pervasive disease, the effects of which can be severe. MicroRNA (miR)-127-5p has been utilized as a novel biomarker for the diagnosis of severe pneumonia. The present study aimed to investigate the function of miR-127-5p during severe pneumonia.

Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling.

Morusin has been traditionally used for the treatment of pneumonia (MPP), but the underlying mechanism remains elusive. The present study aimed to explore the mechanism by which morusin achieves efficacy on mycoplasma pneumonia. Mycoplasma pneumonia model was established in BALB/c mouse and the effects of morusin were evaluated in the model.

Enhanced Osseointegration of Hierarchically Structured Ti Implant with Electrically Bioactive SnO-TiO Bilayered Surface.

The poor osseointegration of Ti implant significantly compromise its application in load-bearing bone repair and replacement. Electrically bioactive coating inspirited from heterojunction on Ti implant can benefit osseointegration but cannot avoid the stress shielding effect between bone and implant. To resolve this conflict, hierarchically structured Ti implant with electrically bioactive SnO-TiO bilayered surface has been developed to enhance osseointegration.

Electrically bioactive coating on Ti with bi-layered SnO-TiO hetero-structure for improving osteointegration.

The potential for the use of electric stimulation to control cell behavior on a surface has been well documented. In terms of orthopaedic applications, there is a need to develop bioactive surfaces with a built-in electric field for clinically relevant materials, such as load-bearing titanium (Ti). In this work, a bi-layered SnO-TiO coating is fabricated via microarc oxidation and subsequent hydrothermal treatment to adjust the surface electrical properties for improving bioactivity.