Associations of subcutaneous fat area and Systemic Immune-inflammation Index with survival in patients with advanced gastric cancer receiving dual PD-1 and HER2 blockade.

Background: Systemic Immune-inflammation Index (SII) and body composition parameters are easily assessed, and can predict overall survival (OS) in various cancers, allowing early intervention. This study aimed to assess the correlation between CT-derived body composition parameters and SII and OS in patients with advanced gastric cancer receiving dual programmed death-1 (PD-1) and human epidermal growth factor receptor 2 (HER2) blockade.

Materials And Methods: This retrospective study enrolled patients with advanced gastric cancer treated with dual PD-1 and HER2 blockade from March 2019 to June 2022.

Fate and mechanistic insights into nanoscale zerovalent iron (nZVI) activation of sludge derived biochar reacted with Cr(VI).

While nanoscale zero-valent iron modified biochar (nZVI-BC) have been widely investigated for the removal of heavy metals, the corrosion products of nZVI and their interaction with heavy metals have not been revealed yet. In this paper, nZVI-BC was synthesized and applied for the removal of Cr(VI). Batch experiments indicated that the adsorption of Cr(VI) fit Langmuir isotherm, with the maximum removal capacity at 172.

[Experimental study on gradient of nerve growth factor immobilized conduits promoting peripheral nerve regeneration in rats].

Objective: To study the effect of the loaded concentration gradient of nerve growth factor (NGF) immobilized conduit on rat peripheral nerve defect repair.

Methods: The peripheral nerve conduits made of poly (epsilon-caprolactone)-block-poly (L-lactide-co-epsilon-caprolactone) were prepared with uniform loads or concentration gradient loads by combining differential absorption of NGF/silk fibroin (SF) coating, and the gradient of NGF was immobilized in the nerve conduits. ELISA method was used to exam the NGF release for 12 weeks in vitro.

Preparation of PLLA/bpV(pic) microspheres and their effect on nerve cells.

In this study, we prepared PLLA/bpV(pic) microspheres, a bpV(pic) controlled release system and examined their ability to protect nerve cells and promote axonal growth. PLLA microspheres were prepared by employing the o/w single emulsification-evaporation technique. Neural stem cells and dorsal root ganglia were divided into 3 groups in terms of the treatment they received: a routine medium group (cultured in DMEM), a PLLA microsphere group (DMEM containing PLLA microspheres alone) and a PLLA/bpV(pic) group [DMEM containing PLLA/bpV(pic) microspheres].