Publications by authors named "Haoruo Zhang"
Objectives: This study aimed to use a stable and predictive method: Lasso regression model to analyze hypertension's influencing factors and explore the interactions between occupational exposures.
Study Design: This has been a nested case-control study.
Methods: The case group consisted of 959 patients with high blood pressure found during the study.
Article Synopsis
- (-)-Epicatechin (EPI) shows potential benefits for heart health by inhibiting TMAO-induced cardiac hypertrophy, which is linked to cardiovascular diseases.
- The study involved both mouse models and heart cells to evaluate the effects of EPI on TMAO-induced cardiac issues, measuring outcomes through plasma TMAO levels and histological heart analyses.
- Results indicated that EPI not only improved cardiac function but also countered the harmful effects of TMAO, including the regulation of various cardiac hypertrophy markers.
Association between dust exposure and lung function levels in steelworkers: mediation analysis of inflammatory biomarkers.
Int Arch Occup Environ Health
November 2024
Article Synopsis
- The study investigated how inflammatory biomarkers influence the relationship between dust exposure and lung function in steelworkers, focusing on 2,315 workers from an iron and steel company in Tangshan.
- Using various health assessments, including questionnaires and pulmonary function tests, the researchers identified significant reductions in lung function levels among those exposed to dust compared to non-exposed workers.
- The findings revealed that while inflammation markers like white blood cells and neutrophils partially mediated the link between dust exposure and lung function, the overall effect was relatively small, with specific percentages indicating the degree of mediation.
Introduction: This study examines how negation is processed in a nonverbal context (e.g., when assessing ▲ ≠ ▲) by speakers of a truth-based system like Mandarin and a polarity-based system like English.
View Article and Find Full Text PDFA Predictive Nomogram for Intensive Care-Acquired Weakness after Cardiopulmonary Bypass.
Ann Thorac Cardiovasc Surg
January 2024
Article Synopsis
- ICUAW is a condition that can affect patients' recovery after surgery involving cardiopulmonary bypass (CPB), and the study aimed to identify its risk factors and create a predictive tool.
- The research involved analyzing data from 473 patients, focusing on various preoperative and postoperative factors, including body mass index (BMI) and surgical times, with over 50% of patients experiencing ICUAW.
- Key risk factors identified include high BMI, poor heart function, elevated serum lactate, low albumin, prolonged surgery, and specific health evaluation scores; the resulting nomogram shows promise for aiding clinical decisions.
Article Synopsis
- Postoperative atrial fibrillation (POAF) commonly occurs after cardiac surgery, influenced by factors like age and blood loss, as well as the debated impact of thyroid hormone (TH) levels.
- This study aimed to analyze the incidence and predictors of POAF, specifically assessing preoperative TH levels as a significant variable, and developed a column graph prediction model.
- In a cohort of 589 patients, the study identified gender, age, leukocyte count, and TSH levels as key risk factors for POAF, and found the predictive model to have a good diagnostic performance with a ROC curve area of 0.747.
Article Synopsis
- - Persistent oxidative stress and inflammation caused by radiation, especially when combined with skin wounds, leads to severe medical complications known as radiation combined with skin wounds (RCSWs), which have not received enough research focus despite their treatment challenges.
- - Researchers developed a multifunctional hydrogel loaded with polydopamine nanoparticles (PDA-NPs) and small extracellular vesicles (MSC-sEV) to improve the harmful microenvironment linked to RCSWs, enhancing cell vitality and wound healing in laboratory tests.
- - Analysis of gene expression related to the hydrogel treatment revealed important roles for pathways involved in wound repair and indicated that this innovative therapy represents a promising approach for managing RCSWs.
Article Synopsis
- - Melasma is a challenging skin condition to treat, and this study investigates the use of human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) as a potential novel treatment option, focusing on their safety and efficacy.
- - In the research, animal studies showed that hUCMSC-Exos could effectively penetrate deeper skin layers when combined with microneedles, laser treatments, and plasma therapy, while a clinical trial with 60 patients tested several treatment combinations.
- - Results indicated that the combinations of hUCMSC-Exos treatments significantly improved treatment outcomes and patient satisfaction compared to a control group, while pain levels varied among the different treatment groups.
Article Synopsis
- * Using advanced single-cell sequencing techniques, researchers identified four distinct WJ-MSC subpopulations, each with different characteristics and functions.
- * Notably, a specific subpopulation (biofunctional-type MSCs) shows significant potential for wound healing, especially since it's more abundant in the fetal umbilical cord, highlighting its promise for future therapies.
Article Synopsis
- * The study analyzed patient data from the Gene Expression Omnibus database to find different miRNAs that could be used in liquid biopsy diagnostics for pancreatic cancer.
- * A total of 11 miRNAs were identified, with miR-4668-5p showing the most potential as a diagnostic biomarker for pancreatic cancer due to its strong association with disease modules.
The main strategy of tissue repair and regeneration focuses on the application of mesenchymal stem cells and cell-based nanoparticles, but there are still multiple challenges that may have negative impacts on human safety and therapeutic efficacy. Cell-free nanotechnology can effectively overcome these obstacles and limitations. Mesenchymal stem cell (MSC)-derived natural small extracellular vesicles (sEVs) represent ideal nanotherapeutics due to their low immunogenicity and lack of tumorigenicity.
View Article and Find Full Text PDFAim: This study aimed to determine whether family-centred care (FCC) intervention reduces the ICU delirium prevalence.
Design: A systematic review and meta-analysis.
Methods: The databases, including PubMed, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL Complete, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), WANFANG Data and VIP Information, were systematically searched up to 30 November 2021.
Introduction: Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and their small extracellular vesicles (hUC-MSC-sEVs) have shown attractive prospects applying in regenerative medicine. This study aimed to compare the therapeutic effects of two agents on osteoarthritis (OA) and investigate underlying mechanism using proteomics.
Methods: In vitro, the proliferation and migration abilities of chondrocytes treated with hUC-MSCs or hUC-MSC-sEVs were detected by Cell Counting Kit-8 assay and scratch wound assay.
Background: As a new surgical method for older adults with cardiac insufficiency, transapical mitral valve clamp surgery requires the cooperation of practitioners across multiple disciplines to ensure appropriate treatment and nursing care. This study aimed to explore the utility of a multidisciplinary team nursing model in the clinical treatment and nursing care of patients undergoing transapical mitral valve clamping.
Methods: Our sample of ten patients included four men (40%) and six women (60%), with a mean age of 71.
Background: Small extracellular vesicles (sEVs) with genetic information secreted by cells play a crucial role in the cellular microenvironment. In this study, our purpose is to explore the characteristics of the small extracellular vesicles of human adipose-derived mesenchymal stromal cells (hADMSC-sEVs) and studied the role of hADMSC-sEVs in improving the survival rate of grafted fat.
Methods: In the present study, we used the transmission electron microscopy, nano-tracking analysis, nanoflow surface protein analysis, and zeta potential value to identify sEVs.
Background: Blood glucose variability is associated with poor prognosis after cardiac surgery, but the relationship between glucose variability and postoperative delirium in patients with acute aortic dissection is unclear. The study aims to investigate the association of blood glucose variability with postoperative delirium in acute aortic dissection patients.
Methods: We prospectively analyzed 257 patients including 103 patients with delirium.
For the preparation of high-performance sound absorption materials, the fabrication of hierarchical pore structure has proven to be an effective way. Herein, cellulose nanofiber (CNF) and melamine foam (MF) were combined by an environmentally friendly method for the first time, which endowed the final composite foam with both macropores and mesopores. The hierarchical pore structure was constructed by cyclic freezing-thawing, which enhanced the multiple reflections and micro-vibration of the sound waves, resulting in an obvious improvement in sound absorption performance.
View Article and Find Full Text PDFBackground: Mesenchymal stem cell-based acellular therapies have been widely exploited in managing hypertrophic scars. However, low maintenance dose and transitory therapeutic effects during topical medication remain a thorny issue. Herein, this study aimed to optimize the curative effect of adipose-derived stem cell conditioned medium (ADSC-CM) in the prevention of hypertrophic scarring.
View Article and Find Full Text PDFBackground: Circular RNAs (circRNAs) function as vital regulators in multifarious cancers, including hepatocellular carcinoma (HCC). However, the roles of circRNA Wolf-Hirschhorn syndrome candidate gene-1 (circWHSC1) in HCC are barely known.
Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted for the levels of circWHSC1, miR-142-3p, miR-421, miR-665 and homeobox A1 (HOXA1) mRNA.
Article Synopsis
- * Out of 280 patients, the incidence of POD was found to be 37.86%, influenced by factors such as high APACHE-II scores, hypoxemia, and the use of multiple analgesics/sedatives, while non-manual work was identified as a protective factor.
- * The findings suggest that certain clinical and demographic factors significantly correlate with the risk of POD, emphasizing the need for careful monitoring and potential interventions in at-risk patients post-surgery.
BACKGROUND Guidelines recommend a clear liquid fasting time of 2 h before surgery, which is often exceeded, leading to adverse reactions (ARs) such as discomfort, thirst, and dehydration. We assessed the gastric contents and ARs after oral glucose water administration 1 h prior to surgery in children with cyanotic congenital heart disease (CCHD). MATERIAL AND METHODS This was a non-inferiority randomized controlled trial of children with CCHD enrolled at the Fujian Medical University Union Hospital from 09/2014 to 05/2017 and randomized to receive oral glucose water (10 g of glucose in 100 ml of warm water, 5 ml/kg) 2 h (2-h group, n=174) or 1 h (1-h group, n=170) before surgery.
View Article and Find Full Text PDFMarkers of prothrombotic state and inflammation are associated with the prognosis of patients with acute type A aortic dissection (AAAD). However, it is unclear that the relationship between these biomarkers and their combined impact on risk stratification. The present study evaluated the prognostic value of platelet counts, lymphocyte to neutrophil ratio (LNR), and lymphocyte to monocyte ratio (LMR), alone and in combination.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates the risk factors for developing posttraumatic stress disorder (PTSD) symptoms in male and female patients after emergency surgery for acute type A aortic dissection (AAAD).
- - Among a sample of 214 AAAD patients, the prevalence of PTSD symptoms was similar in both sexes, with 22.1% in males and 20.0% in females, but different factors influenced the symptoms between the genders.
- - For males, higher depression scores were linked to more PTSD symptoms, while having a university education, strong support, and optimism were linked to lower symptoms; for females, having available support reduced PTSD symptoms while higher depression scores increased them.
Research on structural-functional integration of polymers has become an inevitable trend and development orientation in modern materials science. An intrinsic flame-retardant epoxy with superior mechanical properties and reusability is of great application value as a composite matrix and structural material. We newly synthesized two bio-based epoxy resins, VSE and VDE, the Young's modulus of product cured by DDM (4,4-diaminodiphenyl methane) achieve 5013 MPa and 4869 MPa, respectively.
View Article and Find Full Text PDFThe aim of the study was to evaluate the relationship between lymphocyte to monocyte ratio (LMR) at admission and in-hospital mortality of patients with acute type A aortic dissection (AAAD). We enrolled 536 patients with AAAD between June 2013 and December 2017. Patients were divided into two groups: the deceased group and the survival group.
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