Publications by authors named "Haoran Shan"
Aberrant Super-Enhancer Landscape in Enzalutamide-Resistant Prostate Cancer Cells.
Genet Test Mol Biomarkers
June 2024
Article Synopsis
- - This study focuses on castration-resistant prostate cancer (CRPC), specifically examining how certain noncoding DNA elements known as super enhancers (SEs) play a role in developing resistance to the antiandrogen drug enzalutamide (Enz).
- - Researchers used advanced techniques to identify and analyze 999 SEs in C4-2B cells that have become resistant to Enz, discovering 41 SEs significantly associated with this resistance.
- - They highlighted two key transcription factors, ZNF467 and SMAD3, as critical links between SEs and Enz resistance, suggesting potential new avenues for treatment in CRPC.