Background: Severe pneumonia complicated by myocardial damage is a serious condition in children, and early prediction and intervention are crucial for improving outcomes. To explore the clinical value of serum hyaluronic acid, procollagen III N-terminal propeptide, sST2, and cfDNA levels in predicting myocardial damage in children with severe pneumonia.
Methods: A case-control study was conducted on 140 children with severe pneumonia, divided into a control group (n=70) and a group with disease complicated by myocardial injury (n=70).
Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary tissue damage. The precise molecular controls that dictate the inflammatory behavior of neutrophils post-TBI, however, remain largely elusive. Our comprehensive analysis of the molecular landscape surrounding the trauma in TBI mice has revealed a significant alteration in the abundance of β2 integrin (ITGB2), predominantly expressed by neutrophils and closely associated with immune responses.
View Article and Find Full Text PDFBackground: Estimation of the radiation dose to the fetus is essential for the assessment of radiation risks and benefits to pregnant patients undergoing radiological examinations. During the past decade, the global twinning rate has soared resulting from embryo assistance and increased delivery age. However, to the best of our knowledge, radiation dosimetry in multiple pregnancies from radiological imaging has never been reported before.
View Article and Find Full Text PDFDrug resistance has emerged as a critical challenge in clinical cancer treatment. Here, we present a high-throughput screening protocol to identify therapeutic small-molecule inhibitors against drug-resistant cancer cells. We detail the steps for constructing drug-resistant cell models, executing the chemical screening process, and performing data analysis and validation.
View Article and Find Full Text PDFAdversarial attacks that mislead deep neural networks (DNNs) into making incorrect predictions can also be implemented in the physical world. However, most of the existing adversarial camouflage textures that attack object detection models only consider the effectiveness of the attack, ignoring the stealthiness of adversarial attacks, resulting in the generated adversarial camouflage textures appearing abrupt to human observers. To address this issue, we propose a style transfer module added to an adversarial texture generation framework.
View Article and Find Full Text PDFBackground: Pain is an important issue in botulinum toxin injection. Vibration anesthesia is a noninvasive way for pain alleviation, but few study reported its use during botulinum toxin injection.
Objectives: To investigate whether vibration anesthesia is effective and safe for pain reduction during botulinum toxin injection for masseter reduction.
Cultivated strawberry (Fragaria × ananassa) is a popular, economically important fruit. The ripening of the receptacle (pseudocarp), the main edible part, depends on endogenously produced abscisic acid (ABA) and is suppressed by the high level of auxin produced from achenes (true fruit) during early development. However, the mechanism whereby auxin regulates receptacle ripening through inhibiting ABA biosynthesis remains unclear.
View Article and Find Full Text PDFThe lung is an important site of extramedullary platelet formation, and megakaryocytes in the lung participate in immune responses in addition to platelet production. In acute lung injury and chronic lung injury, megakaryocytes and platelets play a promoting or protective role through different mechanisms. The authors reviewed the role of megakaryocytes and platelets in common clinical lung injuries with different course of disease and different pathogenic factors in order to provide new thinking for the diagnosis and treatment of lung injuries.
View Article and Find Full Text PDFPhytohormones, epigenetic regulation and environmental factors regulate fruit ripening but their interplay during strawberry fruit ripening remains to be determined. In this study, bagged strawberry fruit exhibited delayed ripening compared with fruit grown in normal light, correlating with reduced abscisic acid (ABA) accumulation. Transcription of the key ABA catabolism gene, ABA 8'-hydroxylase FaCYP707A4, was induced in bagged fruit.
View Article and Find Full Text PDFThe tumour-targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an "all-in-one" red blood cell (RBC)-derived microrobot that can hierarchically adapt to five critical stages during systemic drug delivery, that is, circulation, accumulation, release, extravasation, and penetration, is developed.
View Article and Find Full Text PDFTo assess potential variations in the absorbed dose between Chinese and Caucasian children exposed toF-FDG PET scan and to investigate the factors contributing to dose differences, this work employed patient-specific phantoms and our compartment model for calculating the patient-specific absorbed dose in Chinese children.Data of 29 Chinese pediatric patients undergoing whole-bodyF-FDG PET/CT studies were retrospectively collected, including PET images for activity distributions and corresponding CT images for organ segmentation and phantom construction. A biokinetic compartment model was implemented to obtain cumulated activities.
View Article and Find Full Text PDFSelective protein degradation platforms have opened novel avenues in therapeutic development and biological inquiry. Antibody-based lysosome-targeting chimeras (LYTACs) have emerged as a promising technology that extends the scope of targeted protein degradation to extracellular targets. Aptamers offer an advantageous alternative owing to their potential for modification and manipulation toward a multivalent state.
View Article and Find Full Text PDFThe anabolism of tumor cells can not only support their proliferation, but also endow them with a steady influx of exogenous nutrients. Therefore, consuming metabolic substrates or limiting access to energy supply can be an effective strategy to impede tumor growth. Herein, a novel treatment paradigm of starving-like therapy-triple energy-depleting therapy-is illustrated by glucose oxidase (GOx)/dc-IR825/sorafenib liposomes (termed GISLs), and such a triple energy-depleting therapy exhibits a more effective tumor-killing effect than conventional starvation therapy that only cuts off one of the energy supplies.
View Article and Find Full Text PDFThe existence of a delicate redox balance in tumors usually leads to cancer treatment failure. Breaking redox homeostasis by amplifying oxidative stress and reducing glutathione (GSH) can accelerate cancer cell death. Herein, we construct a ferroptosis-reinforced nanocatalyst (denoted as HBGL) to amplify intracellular oxidative stress via dual HO production-assisted chemodynamic therapy (CDT).
View Article and Find Full Text PDFThe imbalance of charge injection is considered to be a major factor that limits the device performance of cadmium-free quantum-dot light-emitting diodes (QLEDs). In this work, high-performance cadmium-free Cu─In─Zn─S(CIZS)-based QLEDs are designed and fabricated through tailoring interfacial energy level alignment and improving the balance of charge injection. This is achieved by introducing a bilayered hole-injection layer (HIL) of Cu-doped NiO (Cu─NiO)/Poly(3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT:PSS).
View Article and Find Full Text PDFBackground: Neuroinflammation is one of the most important pathogeneses in secondary brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming neutrophils were found throughout the brain tissue of TBI patients and elevated plasma NET biomarkers correlated with worse outcomes. However, the biological function and underlying mechanisms of NETs in TBI-induced neural damage are not yet fully understood.
View Article and Find Full Text PDFThe unavoidably positively and negatively charged defects at the interface between perovskite and electron transport layer (ETL) often lead to severe surface recombination and unfavorable energy level alignment in inverted perovskite solar cells (PerSCs). Inserting interlayers at this interface is an effective approach to eliminate charged defects. Herein, the macrocyclic molecule valinomycin (VM) with multiple active sites of ─C═O, ─NH, and ─O─ is employed as an interlayer at the perovskite/ETL contact to simultaneously eliminate positively and negatively charged defects.
View Article and Find Full Text PDFBiochem Biophys Res Commun
July 2023
Traumatic brain injury (TBI) is an important reason of neurological damage and has high morbidity and mortality rates. The secondary damage caused by TBI leads to a poor clinical prognosis. According to the literature, TBI leads to ferrous iron aggregation at the site of trauma and may be a key factor in secondary injury.
View Article and Find Full Text PDFDrought is a common and serious abiotic stress in viticulture, and it is urgent to select effective measures to alleviate it. The new plant growth regulator 5-aminolevulinic acid ALA has been utilized to alleviate abiotic stresses in agriculture in recent years, which provided a novel idea to mitigate drought stress in viticulture. The leaves of 'Shine Muscat' grapevine ( L.
View Article and Find Full Text PDFTwo kinds of triphenylamine-derived solid-state emissive carbon dots (CDs) with orange and yellow color are facilely synthesized through solvothermal treatment, taking advantage of the nonplanar structure and good carrier mobility of triphenylamine unit. Theoretical calculations show that the triphenylamine structure could greatly inhibit the direct π-π stacking of aromatic skeletons and enhance the fluorescence properties of CDs in aggregation state. By adopting the CDs as single emissive layer, high-performance orange-color and green-color electroluminescent light-emitting diodes (LEDs) are successfully fabricated, with maximum brightness of 9450/4236 cd m , high current efficiency of 1.
View Article and Find Full Text PDFLocusta migratoria is a serious agricultural pest in China. Beauveria bassiana is one of the most important pathogens of grasshoppers and locusts. The effects of ultraviolet light were evaluated on the B.
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