Serotonin (5-HT) is a crucial neurotransmitter in the body, with its levels being particularly significant for life safety. Here, we designed the AgBiS/CuMoS S-scheme heterojunction by uniformly immobilizing lamellar CuMoS on the surface of three-dimensional (3D) flower-like AgBiS using a simple physical mixing technique. In this case, AgBiS and CuMoS are bonded together by electrostatic attraction to form an active surface with a large specific surface area.
View Article and Find Full Text PDFDNA-based functional nanomaterials are distinguished by their structural designability and functional controllability, making them particularly attractive in the biomedical field. Using DNA nanomaterials for cancer treatment through synergistic approaches combining photodynamic therapy and photothermal therapy has garnered significant attention. This growing interest has driven the active development of various DNA nanomaterials tailored for integrated strategies targeting cancer, including phototherapy, chemotherapy, etc.
View Article and Find Full Text PDFRespiratory viruses pose an ongoing threat to human health with excessive cytokine secretion contributing to severe illness and mortality. However, the relationship between cytokine secretion and viral infection remains poorly understood. Here we elucidate the role of CXCL8 as an early response gene to EV-D68 infection.
View Article and Find Full Text PDFChem Commun (Camb)
February 2025
Since the d-orbitals of copper are beneficial for adsorption of nitrate and conversion to nitrite, porous carbon nanofiber-supported copper nanoparticles (Cu@CNFs) are proposed as an efficient electrocatalyst for nitrate reduction to ammonia, which achieves a large ammonia yield of 24.22 mg h mg. and a high faradaic efficiency (FE) of 86.
View Article and Find Full Text PDFAcyl-CoA oxidase 1 (ACOX1), a member of the acyl-coenzyme A oxidase family, is considered a crucial regulator whose dysregulation is implicated in the occurrence and progression of various cancers. This study aims to elucidate the impact of ACOX1 in CRC, shedding light on its potential as a therapeutic target. Through analysis of the GEO dataset, it was found that ACOX1 is significantly downregulated in colorectal cancer (CRC), and this lower expression level is associated with a worse prognosis.
View Article and Find Full Text PDFOncolytic vaccinia viruses (VVs) are potent stimulators of the immune system and induce immune-mediated tumor clearance and long-term surveillance against tumor recurrence. As such they are ideal treatment modalities for solid tumors including lung cancer. Here, we investigated the use of VVL-m12, a next-generation, genetically modified, interleukin-12 (IL-12)-armed VV, as a new therapeutic strategy to treat murine models of lung cancer and as a mechanism of increasing lung cancer sensitivity to antibody against programmed cell death protein 1 (α-PD1) therapy.
View Article and Find Full Text PDFEnterovirus D68 (EV-D68) is a leading non-polio enterovirus that causes severe respiratory diseases and poliomyelitis-like illness in children. Viral entry represents a potential multifaceted target for antiviral intervention; however, there are no approved inhibitors to block EV-D68. Here, we identify the functionally undescribed membrane protein major facilitator superfamily-domain-containing protein 6 (MFSD6) as an EV-D68 entry factor amenable to therapeutic intervention.
View Article and Find Full Text PDFSheng Li Xue Bao
December 2024
The maintenance of skeletal muscle quality involves various signal pathways that interact with each other. Under normal physiological conditions, these intersecting signal pathways regulate and coordinate the hypertrophy and atrophy of skeletal muscles, balancing the protein synthesis and degradation of muscle. When the total rate of protein synthesis exceeds that of protein degradation, the muscle gradually becomes enlarged, while when the total rate of protein synthesis is lower than that of protein degradation, the muscle shrinks.
View Article and Find Full Text PDFObjective: This study aimed to compare the effectiveness of various conservative treatment strategies for women with stress urinary incontinence.
Methods: A comprehensive search of PubMed, Web of Science, Embase, and the Cochrane Library was conducted from their inception through March 2024, without restrictions on language or location. Randomized controlled trials (RCTs) comparing the efficacy of conservative treatments for stress urinary incontinence, using short-term pad test or the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) score as outcome measures, were included.
J Colloid Interface Sci
April 2025
During tunnel construction, the protracted mucking phase poses significant occupational health risks, particularly from dust exposure. This study delves into comprehensive numerical simulations to examine the spatiotemporal dynamics of dust particles during the mucking process. A distinct 'bimodal pattern' was characterized by higher concentrations in the mucking area (0-30 m) and the inverted arch area (60-110 m), where concentrations exceed 30 mg/m3 under all conditions.
View Article and Find Full Text PDFAccurate and timely pest and disease monitoring during the cultivation process of traditional Chinese medicinal materials is crucial for ensuring optimal growth, increased yield, and enhanced content of effective components. This paper focuses on the essential requirements for pest and disease monitoring in a planting base of Cinnamomum Camphora var. Borneol (CCB) and presents a solution using unmanned aerial vehicle (UAV) images to address the limitations of real-time and on-site inspections.
View Article and Find Full Text PDFNon-obstructive azoospermia (NOA) is the most incurable form of male infertility with a complex etiology. Long non-cording RNAs (lncRNAs) were associated with regulating spermatogenesis. Herein, differentially expressed lncRNAs between NOA and control male were screened by RNA-seq analysis.
View Article and Find Full Text PDFPolyvinyl alcohol (PVA) hydrogels find applications in various fields, including machinery and tissue engineering, owing to their exceptional mechanical properties. However, the mechanical properties of PVA hydrogels are subject to alteration due to environmental factors such as temperature, affecting their prolonged utilization. To enhance their lifespan, it is crucial to investigate their aging mechanisms.
View Article and Find Full Text PDFA Gram-stain-negative, aerobic, motile and rod-shaped bacterium, the color of the bacterial colony ranges from light yellow to yellow, designated YC-2023-2T, was isolated from sediment sample of Yuncheng salt lake. Growth occurred at 15-45℃ (optimum 37℃), pH 6.0-9.
View Article and Find Full Text PDFDespite the efficacy of highly active antiretroviral therapy in controlling the incidence and mortality of AIDS, effective interventions for HIV-1-induced neurological damage and cognitive impairment remain elusive. In this study, we found that HIV-1 infection can induce proteolytic cleavage and aberrant aggregation of TAR DNA-binding protein 43 (TDP-43), a pathological protein associated with various severe neurological disorders. The HIV-1 accessory protein Vpu was found to be responsible for the cleavage of TDP-43, as ectopic expression of Vpu alone was sufficient to induce TDP-43 cleavage, whereas HIV-1 lacking Vpu failed to cleave TDP-43.
View Article and Find Full Text PDFThe development of bifunctional, non-noble metal-based electrocatalysts for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) through morphology and electronic engineering is highly attractive for efficient water splitting. Herein, hierarchical nanoarrays consisting of crystalline cobalt phosphide nanorods covered by amorphous Fe-doped cobalt phosphide nanocuboids (CoP/FeCoP) are constructed as bifunctional catalysts for both HER and OER. Experimental results and theoretical calculations reveal that the catalysts exhibit balanced dual-catalytic properties due to simultaneous introduction of Fe doping and phosphorus vacancies, leading to an optimized electronic structure of the CoP/FeCoP.
View Article and Find Full Text PDFObjective: Post-stroke dysphagia (PSD) is a common complication of stroke. Acupuncture as one of the traditional therapies in traditional Chinese medicine (TCM), can change the excitability of cerebral cortical nerve cells, and promote the recovery of neurological and swallowing functions. Several clinical primary studies (including RCTs, cohort studies, etc.
View Article and Find Full Text PDFTo investigate the effects of long-term prestress loss on concrete box girders strengthened with external prestressing, a large-span box girder, in service for over 20 years and strengthened with external prestressing, was monitored for four months. Prestress loss in the longitudinal, vertical, and transverse directions of the box girder was calculated according to Chinese code requirements. Magnetic flux rope force transducers were used to monitor the prestress loss in the external prestressing cables.
View Article and Find Full Text PDFA comprehensive analysis of spatial transcriptomics was carried out to better understand the progress of halo nevus. We found that halo nevus was characterized by overactive immune responses, triggered by chemokines and dendritic cells (DCs), T cells, and macrophages. Consequently, we observed abnormal cell death, such as apoptosis and disulfidptosis in halo nevus, some were closely related to immunity.
View Article and Find Full Text PDFObjective: This retrospective study aimed to investigate the factors influencing the occurrence of neutropenia in patients with endometrial cancer (EC) following adjuvant chemoradiotherapy (CRT).
Methods: Retrospective analysis of EC patients who underwent adjuvant CRT from January 2012 to June 2023 in the Department of Gynecology and Oncology of the First Affiliated Hospital of Shandong First Medical University. Neutropenia was defined as an Absolute Neutrophil Count (ANC) of peripheral blood neutrophils below 2 × 10/L.