A novel type III effector RipBU from Ralstonia solanacearum suppresses plant immunity and promotes peanut susceptibility.

A predicted peanut R. solanacearum T3E RS_T3E_Hyp6 was identified as a definite T3E and renamed as RipBU. It is relative conserved in 31 R.

The actin-binding protein drebrin disrupts NF2-LATS kinases complex assembly to facilitate liver tumorigenesis.

Background And Aims: The Hippo signaling has emerged as a crucial regulator of tissue homeostasis, regeneration, and tumorigenesis, representing a promising therapeutic target. Neurofibromin 2 (NF2), a component of Hippo signaling, is directly linked to human cancers but has been overlooked as a target for cancer therapy.

Approach And Results: Through a high-content RNA interference genome-wide screen, the actin-binding protein Drebrin (DBN1) has been identified as a novel modulator of YAP localization.

Construction of a Three-Phase MnS/CoS/NiS Heterostructure for Boosting Oxygen Evolution.

The rational construction of highly efficient electrocatalysts for the oxygen evolution reaction (OER) plays a critical role in energy conversion systems. Designing heterostructures is a common and effective strategy to improve the performance of electrocatalysts. In this paper, an MnS/CoS/NiS heterostructure was synthesized on Ni foam using a one-step vulcanization method.

Mechanisms for initiation of food allergy by skin pre-disposed to atopic dermatitis.

Food allergy can be life-threatening and often develops early in life. In infants and children, loss-of-function mutations in skin barrier genes associate with food allergy. In a mouse model with skin barrier mutations (Flakey Tail, FT+/- mice), topical epicutaneous sensitization to a food allergen peanut extract (PNE), an environmental allergen Alternaria alternata (Alt) and a detergent induce food allergy and then an oral PNE-challenge induces anaphylaxis.

S1PR3 suppresses the inflammatory response and extracellular matrix degradation in human nucleus pulposus cells.

Sphingosine 1-phosphate receptor 3 (S1PR3) participates in the inflammatory response in multiple types of diseases. However, the biological role of S1PR3 in intervertebral disc degeneration and the underlying mechanism are unclear. The aim of the present study was to investigate the functional role and the mechanism of S1PR3 in lipopolysaccharide (LPS)-induced human nucleus pulposus cells.

Constructing cropland ecological stability assessment method based on disturbance-resistance-response processes and classifying cropland ecological types.

The cropland ecosystem stability (CES) has received increasing attention, especially in ecologically fragile areas, because of its impact on cropland quality, agricultural production and its ability to resist external disturbances. In this study, we first introduced the concepts of resilience and resistance, proposed the ecosystem disturbance-resistance-response process, and established a framework for evaluating the spatial and temporal dynamics of the CES based on RS data, and innovatively combined the RS assessment results of CES with soil field samples data to further classify cropland ecological types (CET) in a key agricultural areas of the Qinghai-Tibetan Plateau, which can effectively identify those croplands in need of priority ecological protection. Results indicate that the combined interactions of disturbance, resistance and response systems affect CES, forming a complex process with significant fluctuations and spatial variations.

Advances in Gluten Hypersensitivity: Novel Dietary-Based Therapeutics in Research and Development.

Gluten hypersensitivity is characterized by the production of IgE antibodies against specific wheat proteins (allergens) and a myriad of clinical allergic symptoms including life-threatening anaphylaxis. Currently, the only recommended treatment for gluten hypersensitivity is the complete avoidance of gluten. There have been extensive efforts to develop dietary-based novel therapeutics for combating this disorder.

A remarkable new species and one newly recorded species of genus Oxyartes Stl, 1875 (Phasmida, Lonchodidae, Necrosciinae) from China.

The genus Oxyartes currently comprises 17 taxa, of which 12 are found in China, representing the high diversity in China. This list includes the two species from China as described in this paper. The first is a new remarkable species O.

Comparative study on the technique and efficacy of microscope-assisted MI-TLIF and naked-eye MI-TLIF in lumbar revision surgery.

Background: Lumbar revision surgery can be performed by simple lumbar nerve decompression or lumbar interbody fusion, including percutaneous endoscopic lumbar discectomy, transforaminal lumbar interbody fusion (TLIF), etc. However, lumbar revision surgery is very difficult in surgical operation. We sought to explore the technique safety and efficacy of microscope-assisted minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) in lumbar revision surgery.

Learnable Leakage and Onset-Spiking Self-Attention in SNNs with Local Error Signals.

Spiking neural networks (SNNs) have garnered significant attention due to their computational patterns resembling biological neural networks. However, when it comes to deep SNNs, how to focus on critical information effectively and achieve a balanced feature transformation both temporally and spatially becomes a critical challenge. To address these challenges, our research is centered around two aspects: structure and strategy.

Is Wheat Glutenin Extract Intrinsically Allergenic? Evaluation Using a Novel Adjuvant-Free Mouse Model of Systemic Anaphylaxis.

Wheat is a prominent allergenic food that can trigger life-threatening anaphylaxis. Presently, it remains unclear whether wheat glutenin (WG) extract possesses inherent sensitization potential independently, without the use of adjuvants, and whether it can sensitize mice to the extent of inducing life-threatening systemic anaphylaxis. In this study, we tested the hypothesis that repeated skin exposures to WG extract without adjuvant will sensitize mice with the resultant anaphylactic reaction upon systemic WG challenge.

Comparison study of anterior cervical zero-profile fusion cage (ROI-C) and traditional titanium plate plus fusion technique for the treatment of spinal cord type cervical spondylosis.

A retrospective comparative study. To compare and analyze the differences in the efficiency and safety of ROI-C and traditional titanium plate with fusion cage for the treatment of CSM patients. Clinical data of 105 patients with CSM who underwent surgical treatment at our hospital from January 2019 to December 2020 were retrospectively reviewed.

Chronic application of alcohol-soluble gluten extract over undamaged skin causes clinical sensitization for life-threatening anaphylaxis via activation of systemic Th2 immune responses in mice.

Introduction: Gluten allergy is a major public health problem that is growing at an alarming rate. Specific mechanisms underlying sensitization to gluten remain incompletely understood. Currently, it is unclear whether chronic exposure to alcohol-soluble gluten extract via undamaged skin has the capacity to clinically sensitize mice for life-threatening anaphylaxis.

Enhanced covertness class discriminative universal adversarial perturbations.

The main aim of class discriminative universal adversarial perturbations (CD-UAPs) is that the adversary can flexibly control the targeted class and influence remaining classes limitedly. CD-UAPs generated by the existing attack strategies suffer from a high fooling ratio of non-targeted source classes under non-targeted and targeted attacks, and face the increasing risk of discovery. In this paper, we propose a training framework for generating enhanced covertness CD-UAPs.

First report of the genus Spinomarmessoidea (Phasmatodea, Lonchodidae, Necrosciinae) from China, with the description of a new species.

The recently described genus Spinomarmessoidea is comprised of only 2 species from Peninsular Malaysia. The 3rd species of this genus, Spinomarmessoidea damingensis sp. nov.

Intrinsic Allergenicity Potential of Salt-Soluble Protein Extracts from the Diploid, Tetraploid and Hexaploid Wheats: Validation Using an Adjuvant-Free Mouse Model.

Wheat allergies are potentially life-threatening and, therefore, have become a major health concern at the global level. It is largely unknown at present whether genetic variation in allergenicity potential exists among hexaploid, tetraploid and diploid wheat species. Such information is critical in establishing a baseline allergenicity map to inform breeding efforts to identify hyper-, hypo- and non-allergenic varieties.

How to Regulate the Infringements of Geographical Indications of Agricultural Products-An Empirical Study on Judicial Documents in China.

Under the background of China's strategy of becoming a powerful agricultural country, geographical indications (GIs) of agricultural products, as an important intellectual property right to enable Chinese agriculture to develop with high quality, have a strong effect of strengthening and promoting agriculture. However, there are a large number of infringements of GIs among agricultural products in judicial practice, which not only greatly damage the economic and social values of GIs of agricultural products, but also bring huge food safety hazards to consumers and hinder the overall protection of intellectual property rights in China. On this basis, this paper, with the help of a quasi-case research method, integrates the facts of relevant cases, the focus of disputes, the application of law, and other case elements to realize the case similarity judgment based on the legal argumentation model.

Efficacy and safety of pharmacologic therapies for prevention of osteoporotic vertebral fractures in postmenopausal women.

Background: There are many pharmaceutical interventions available to prevent osteoporotic vertebral fractures in postmenopausal women, but the efficacy and safety of these drugs are unknown. This study aimed to investigate the efficacy and safety of drugs in the prevention of osteoporotic vertebral fractures.

Methods: PubMed, Embase, and the Cochrane Library were comprehensively searched for randomized controlled trials (RCTs) published up to February 15, 2020, including postmenopausal women with osteoporosis.

Correlation Between Rats Hippocampal ATP Content and Delayed Encephalopathy After Acute Carbon Monoxide Poisoning.

Objective: To study the correlation between the adenosine triphosphate (ATP) content in the hippocampus of rats and delayed encephalopathy after acute carbon monoxide (CO) poisoning.

Methods: A total of 40 male Wistar rats weighing 180-230g, in accordance with the random number table, were selected and divided into the delayed encephalopathy after acute carbon monoxide poisoning (DEACMP: Rats with cognitive impairment after carbon monoxide poisoning) group (n = 32) and the control group (n = 8). A DEACMP rat model was generated by inhalation of CO.

Physiological and Transcriptomic Analyses Revealed That Humic Acids Improve Low-Temperature Stress Tolerance in Zucchini ( L.) Seedlings.

Zucchini ( L.) is one of the main vegetable crops grown under protected cultivation in northern China. Low-temperature (LT) stress severely inhibits the growth of zucchini seedlings, resulting in reductions in yield and quality.

A U-shaped association of tracheostomy timing with all-cause mortality in mechanically ventilated patients admitted to the intensive care unit: A retrospective cohort study.

Objectives: To evaluate the association of tracheostomy timing with all-cause mortality in patients with mechanical ventilation (MV).

Method: It's a retrospective cohort study. Adult patients undergoing invasive MV who received tracheostomy during the same hospitalization based on the Medical Information Mart for Intensive Care-III (MIMIC-III) database, were selected.

[Spatial and Temporal Distribution and Source Variation of Heavy Metals in Cultivated Land Soil of Xiangzhou District Based on EBK Interpolation Prediction and GDM Model].

In order to explore the spatial and temporal changes in spatial patterns and source changes in heavy metals in Xiangzhou District, 395 and 326 soil samples were collected from cultivated soil in Xiangzhou District in November 2009 and November 2019, respectively. The contents of Cr, Pb, As, Hg, and Cd during these two years were measured. The spatial pattern and variation distribution of five types of heavy metals during these two years were obtained by using the empirical Bayesian Kriging (EBK) method.

Regulation of soliton inside microresonators with multiphoton absorption and free-carrier effects.

The influence of frequency detuning on the field in silicon microresonators with multiphoton absorption and FC effect is investigated. In this study, results show that frequency detuning facilitates soliton generation. With appropriate frequency detuning, not only bright solitons but also dark ones can be excited in silicon microresonators, which compensates for the absence of solitons with multiphoton absorption and FC.