MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma.

Dissolving the lipid droplets in tissue section with alcohol during a hematoxylin and eosin (H&E) stain causes the tumor cells to appear like clear soap bubbles under a microscope, which is a key pathological feature of clear cell renal cell carcinoma (ccRCC). Mitochondrial dynamics have been reported to be closely associated with lipid metabolism and tumor development. However, the relationship between mitochondrial dynamics and lipid metabolism reprogramming in ccRCC remains to be further explored.

Vacuum-Assisted Conventional Minimally Invasive Percutaneous Nephrolithotomy for the Treatment of Two-to-Four-Centimeter Stones: A Multicenter Prospective and Randomized Trial.

Percutaneous nephrolithotomy (PCNL) is the recommended treatment for 2-4-cm renal stones. Minimally invasive PCNL (MPCNL) with ≤22F sheath was frequently used instead of standard PCNL. MPCNL uses pressurized irrigation to flush out stone fragments through a conventional nephrostomy sheath (cNS), which may result in higher intrarenal pressure (IRP) and longer operating time.

Bioinspired Multiple Stimuli-Responsive Optical Microcapsules Enabled by Microfluidics.

Optical microcapsules encapsulating optical materials inside a symmetric spherical confinement are significant elements for the construction of optical units and the integration of optical arrays. However, the multiple stimuli-responsive characteristic of optical microcapsules still remains a challenge due to the insuperable physical barrier between the optical material core and the outside shell and the lack of effective mechanisms to trigger the dynamic switch of the encapsulated optical materials. Inspired by the dual-mode optical modulation of chameleon skins, a novel biomimetic binary optical microcapsule that combines the visible light reflection of chiral nematic liquid crystals and photoluminescence emission of rare-earth complexes is assembled by microfluidic emulsification and interfacial polymerization.