Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet.

Neuroinflammation is associated with neurodegenerative diseases, including Alzheimer's and Parkinson's. The cytokine interleukin-12 activates signal transducer and activator of transcription 4 (Stat4), and consumption of a high-fat, high-cholesterol diet (HFD-C) and Stat4 activity are associated with inflammation, atherosclerosis, and a diabetic metabolic phenotype. In studies of in vitro hippocampal slices from control Stat4Ldlr mice fed a HFD-C diabetogenic diet, we show that Schaffer collateral-CA1 synapses exhibited larger reductions in activity-dependent, long-term potentiation (LTP) of synaptic transmission, compared to mice fed a standard diet.

Efficient removal of heavy metals from aqueous solutions using Mn-doped FeOOH: Performance and mechanisms.

The treatment of heavy metal ion contamination in aquatic ecosystems has been a growing global concern for centuries. Iron oxide nanomaterials are effective in heavy metals removal, but are frequently challenging due to the precipitation of Fe(III) and poor reusability. To improve the removal of heavy metals by iron hydroxyl oxide (FeOOH), the iron-manganese oxide material (FMBO) was separately prepared to remove Cd(II), Ni(II), and Pb(II) in individual and multiple systems.

Enhancement of perfluorooctanoic acid and perfluorooctane sulphonic acid removal in constructed wetland using iron mineral: Performance and mechanisms.

Polyfluoroalkyl substance (PFAS) pose a threat to the aquatic environment due to their environmental persistence. The removal of PFAS using constructed wetlands (CWs) has received interest, but the adsorption saturation and limited removal capacity of the substrate is frequently challenging. To enhance the microbial degradation and performance of the substrate, different configurations of iron minerals were used as substrate to remove perfluorooctane sulphonic acid (PFOS) and perfluorooctanoic acid (PFOA) from CWs.

Enhanced benzofluoranthrene removal in constructed wetlands with iron- modified biochar: Mediated by dissolved organic matter and microbial response.

Polycyclic aromatic hydrocarbons (PAHs) pose a high risk to ecosystems owing to their adverse environmental effects. The use of biochar in constructed wetlands (CWs) to remove PAH has received increased interest, but is frequently challenging because of saturation adsorption. To enhance the microbial degradation, electron acceptors are provided.

Recent advances in application of iron-manganese oxide nanomaterials for removal of heavy metals in the aquatic environment.

Heavy metal pollution has a serious negative impact on the ecological environment and human health due to its toxicity, persistence, and non-biodegradable properties. Among the technologies applied in heavy metals removal, adsorption has been widely used as the most promising method because of its simple operation, high removal efficiency, strong applicability, and low cost. Iron-manganese oxide nanomaterials, as an effective absorbent, have attracted wide attention due to their simple preparation, wide material sources, and lower ecological impact.