Nitric oxide and mitochondrial function in cardiovascular diseases.

Nitric oxide (NO) has been highlighted as an important factor in cardiovascular system. As a signaling molecule in the cardiovascular system, NO can relax blood vessels, lower blood pressure, and prevent platelet aggregation. Mitochondria serve as a central hub for cellular metabolism and intracellular signaling, and their dysfunction can lead to a variety of diseases.

Three-Dimensional Carbon Nanotubes Buffering Interfacial Stress of the Silicon/Carbon Anodes for Long-Cycle Lithium Storage.

Silicon/graphite composites show a high specific capacity and improved cycling stability. However, the intrinsic difference between silicon and graphite, such as unequal volume expansion and lithium-ion diffusion kinetics, causes persistent stress at the silicon/graphite interface and the expansion of the electrical isolation region. Herein, carbon nanotubes (CNTs) were successfully introduced into silicon/carbon composites via ball milling and spray drying, which effectively relieved the stress concentration at the direct contact interface and formed a three-dimensional conductive structure.

Rapid diagnosis of canine respiratory coronavirus, canine influenza virus, canine distemper virus and canine parainfluenza virus with a Taqman probe-based multiplex real-time PCR.

Canine Infectious Respiratory Disease Complex (CIRDC) is a highly infectious diseases. Canine respiratory coronavirus (CRCoV), Canine influenza virus (CIV), Canine distemper virus (CDV), and Canine parainfluenza virus (CPiV) are crucial pathogens causing CIRDC. Due to the similar clinical symptoms induced by these viruses, differential diagnosis based solely on symptoms can be challenging.

Dietary Flavonoids Consumption and Health: An Umbrella Review.

Scope: The current evidence between dietary flavonoids consumption and multiple health outcomes is inadequate and inconclusive. To summarize and evaluate the evidence for dietary flavonoids consumption and multiple health outcomes, an umbrella review of meta-analyses and systematic reviews is conducted.

Methods And Results: PubMed, Ovid-EMBASE, and the Cochrane Database of Systematic Reviews are searched up to January 2024.

Ultrasound-targeted microbubble destruction rapidly improves left ventricular function in rats with ischemic cardiac dysfunction.

Background: Previous studies have demonstrated the efficacy of ultrasound-targeted microbubble destruction (UTMD) in the treatment of ischemic heart failure (HF). The purpose of this study was to explore the mechanism by which UTMD improves ischemic HF.

Methods: An ischemic heart failure model was established using Sprague-Dawley rats.

Sex- and time-specific associations of obesity with glycaemic traits: A two-step multivariate Mendelian randomization study.

Aim: To assess the sex- and time-specific causal effects of obesity-related anthropometric traits on glycaemic traits.

Materials And Methods: We used univariate and multivariate Mendelian randomization to assess the causal associations of anthropometric traits (gestational variables, birth weight, childhood body mass index [BMI], BMI, waist-to-hip ratio [WHR], BMI-adjusted WHR [WHR BMI]) with fasting glucose and insulin in Europeans from the Early Growth Genetics Consortium (n ≤ 298 142), the UK Biobank, the Genetic Investigation of Anthropometric Traits Consortium (n ≤ 697 734; females: n ≤ 434 794; males: n ≤ 374 754) and the Meta-Analyses of Glucose and Insulin-related traits Consortium (n ≤ 151 188; females: n ≤ 73 089; males: n ≤ 67 506), adjusting for maternal genetic effects, smoking, alcohol consumption, and age at menarche.

Results: We observed a null association for gestational variables, a negative association for birth weight, and positive associations for childhood BMI and adult traits (BMI, WHR, and WHR BMI).

Effects of adding adjuvants to propofol on the post-anesthesia cognitive function in patients undergoing gastroscopy/colonoscopy: a systematic review and meta-analysis.

Objectives: This study aimed to elucidate the effects of propofol plus adjuvants on postoperative cognitive dysfunction (POCD) and patient satisfaction.

Methods: Studies published up to September 2023 on the Chinese National Knowledge Infrastructure (CNKI), Wanfang Data, Sinomed, PubMed, Embase, Cochrane Library, Web of Science, and Clinictrials.gov websites were searched.

Systemic inflammation mediates the association between environmental tobacco smoke and depressive symptoms: A cross-sectional study of NHANES 2009-2018.

Background: Depression is associated with both environmental tobacco smoke (ETS) and inflammation. However, whether systemic inflammation mediates the ETS-depression relationship is unclear.

Methods: We analyzed 19,612 participants from the 2009-2018 National Health and Nutrition Examination Survey (representing approximately 206,284,711 USA individuals), utilizing data of depressive symptoms (assessed by Patient Health Questionnaire-9), blood cotinine level (an ETS biomarker), dietary inflammatory index (DII, assessed by 24-h dietary recall) and inflammation, represented by immune-inflammation index (SII) and systemic inflammation response index (SIRI).

Effects of bromine-containing counterion salts in directing the structures of medium-sized silver nanoclusters.

The preparation and structural determination of silver nanoclusters (especially the medium-sized Ag clusters) remain more challenging relative to those of their gold counterparts because of the comparative instability of the former. In this work, three medium-sized Ag clusters were controllably synthesized and structurally determined, namely, [Ag(S-Adm)BrH] (Ag for short), Ag(S-Adm)BrH (Ag for short), and [Ag(S-Adm)Br(NO)H] (Ag for short) nanoclusters. Specifically, the introduction of PPhBr gave rise to the generation of Ag and Ag nanoclusters with homologous compositions and configurations, while the TOABr salt selected Ag as the sole cluster product, whose geometric structure was completely different from those of Ag and Ag nanoclusters.

Shared Genetics and Comorbid Genes of Amyotrophic Lateral Sclerosis and Parkinson's Disease.

Background: Comorbidity exists between amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), but the role of genetic factors is unclear.

Objective: We aim to investigate genetic correlation, causal relationship, and comorbid genes between ALS and PD.

Methods: Leveraging the largest genome-wide association study data (ALS: 27,205 cases, 110,881 controls; PDG: 33,674 cases, 449,056 controls), we used linkage disequilibrium score regression and Mendelian randomization analysis for genetic correlation and causal inference.

Slice Visualization for Imaging Nanocluster Transformations.

Metal nanoclusters have served as an emerging class of modular nanomaterials. Several efficient strategies have been proposed for transforming cluster precursors into new nanoclusters with customized structures and enhanced performance. However, such nanocluster transformations have still been in a "blind box" state, meaning that the existing intermediates were hard to track with atomic precision.

Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis.

Background: Observational studies suggest a correlation between post-traumatic stress disorder (PTSD) and gastrointestinal tract (GIT) disorders. However, the genetic overlap, causal relationships, and underlining mechanisms between PTSD and GIT disorders were absent.

Methods: We obtained genome-wide association study statistics for PTSD (23 212 cases, 151 447 controls), peptic ulcer disease (PUD; 16 666 cases, 439 661 controls), gastroesophageal reflux disease (GORD; 54 854 cases, 401 473 controls), PUD and/or GORD and/or medications (PGM; 90 175 cases, 366 152 controls), irritable bowel syndrome (IBS; 28 518 cases, 426 803 controls), and inflammatory bowel disease (IBD; 7045 cases, 449 282 controls).

Machine Learning to Predict the Response to Lenvatinib Combined with Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma.

Background: Lenvatinib and transarterial chemoembolization (TACE) are first-line treatments for unresectable hepatocellular carcinoma (HCC), but the objective response rate (ORR) is not satisfactory. We aimed to predict the response to lenvatinib combined with TACE before treatment for unresectable HCC using machine learning (ML) algorithms based on clinical data.

Methods: Patients with unresectable HCC receiving the combination therapy of lenvatinib combined with TACE from two medical centers were retrospectively collected from January 2020 to December 2021.

Association of daytime napping frequency and schizophrenia: a bidirectional two-sample Mendelian randomization study.

Background: The bidirectional causal association between daytime napping frequency and schizophrenia is unclear.

Methods: A bidirectional two-sample Mendelian randomization (MR) analysis was conducted with summary statistics of top genetic variants associated with daytime napping frequency and schizophrenia from genome-wide association studies (GWAS). The single nucleotide polymorphisms (SNPs) data of daytime napping frequency GWAS came from the UK Biobank (n = 452,633) and 23andMe study cohort (n = 541,333), while the schizophrenia GWAS came from the Psychiatric Genomics Consortium (PGC, 36,989 cases and 113,075 controls).

A Novel Blade Vibration Monitoring Experimental System Based on Blade Tip Sensing.

Due to its non-intrusive manner, blade tip timing (BTT) is considered a potential tool for the condition monitoring of turbomachinery. The challenge of BTT relates to significant under-sampled signal processing, which is induced by a lower number of probes. Signal processing assumes that the ability of the hardware system can meet the requirements of the software algorithm.

Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study.

Background: Observational studies have revealed that dried fruit intake may be associated with cancer incidence; however, confounding factors make the results prone to be disturbed. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causal relationship between dried fruit intake and 11 site-specific cancers.

Materials And Methods: Forty-three single nucleoside polymers (SNPs) with robust genome-wide association study (GWAS) evidence, strongly correlated with dried fruit intake, were used as instrumental variables (IVs) in this study.

Identification and Validation of a Prognostic Prediction Model of m6A Regulator-Related LncRNAs in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a highly invasive malignancy prone to recurrence, and patients with HCC have a low 5-year survival rate. Long non-coding RNAs (lncRNAs) play a vital role in the occurrence and development of HCC. N6-methyladenosine methylation (m6A) is the most common modification influencing cancer development.

Toll-Like Receptor 4 Regulates Rabies Virus-Induced Humoral Immunity through Recruitment of Conventional Type 2 Dendritic Cells to Lymph Organs.

Rabies, caused by rabies virus (RABV), is fatal to both humans and animals around the world. Effective clinical therapy for rabies has not been achieved, and vaccination is the most effective means of preventing and controlling rabies. Although different vaccines, such as live attenuated and inactivated vaccines, can induce different immune responses, different expressions of pattern recognition receptors (PRRs) also cause diverse immune responses.

Steady-state and time-resolved upconversion photoluminescence in Yb-Er co-doped transparent ceramics of YAG.

Transparent ceramics (TCs) represent a new family of functional hard materials. In this Letter, steady-state and time-resolved upconversion photoluminescence in - co-doped TC of yttrium aluminum garnet (TC-YAG) are reported for the first time, to the best of our knowledge. Under the excitation of near-infrared 940 nm laser at room temperature, the - co-doped TC-YAG emits intense multi-color luminescence consisting of cyan, green, and red groups of sharp lines.

Wavelet Element Modelling for Inviscid Fluid-Solid Coupling Problem based on Partitioned Approach.

To provide a simple numerical formulation based on fixed grids, a wavelet element method for fluid-solid modelling is introduced in this work. Compared with the classical wavelet finite element method, the presented method can potentially handle more complex shapes. Considering the differences between the solid and fluid regions, a damping-like interface based on wavelet elements is designed, in order to ensure consistency between the two parts.

Synthesis and catalytic performance of polydopamine supported metal nanoparticles.

Polydopamine (PDA) is an emerging nature-inspired biopolymer material that possesses many interesting properties including self-assembly and universal adhesion. PDA is also able to form coordination bonds with various metal ions, which can be reduced to metal nanoparticles (NPs) as a result of thermal annealing under protective environment. In this study, PDA has been utilized as a support material to synthesize Pt NPs in an aqueous solution at room temperature.

Linking emotions to behaviors through deep transfer learning.

Human behavior refers to the way humans act and interact. Understanding human behavior is a cornerstone of observational practice, especially in psychotherapy. An important cue of behavior analysis is the dynamical changes of emotions during the conversation.

Monophosphoryl-Lipid A (MPLA) is an Efficacious Adjuvant for Inactivated Rabies Vaccines.

Rabies, as one of the most threatening zoonoses in the world, causes a fatal central nervous system (CNS) disease. So far, vaccination with rabies vaccines has been the most effective measure to prevent and control this disease. At present, inactivated rabies vaccines are widely used in humans and domestic animals.

Mechanism of Single-Photon Upconversion Photoluminescence in All-Inorganic Perovskite Nanocrystals: The Role of Self-Trapped Excitons.

The efficient single-photon upconversion photoluminescence (UCPL) feature of lead halide perovskite semiconductors makes it promising for developing laser cooling devices. This is an attractive potential application, but the underlying physics still remains unclear so far. By using the all-inorganic CsPbX (X = Br, I) nanocrystal samples, this phenomenon was investigated by photoluminescence (PL) and time-resolved PL under different temperatures and various excitation conditions.