Publications by authors named "Haopeng Zhao"
Determination of furmonertinib in human plasma and cerebrospinal fluid by UPLC-MS/MS: Application in lung cancer patients with and without brain metastasis.
J Chromatogr B Analyt Technol Biomed Life Sci
November 2024
Article Synopsis
- Furmonertinib (AST2818) is a TKI being developed for treating non-small cell lung cancer in patients with EGFR mutations, and its levels in plasma and CSF help assess its effectiveness in the CNS.
- This paper outlines a UPLC-MS/MS method for measuring furmonertinib in human plasma and CSF, using a specific setup that allows for accurate detection and quantification.
- The methods demonstrated high sensitivity, reliability, and accuracy, which are essential for determining furmonertinib's potential effectiveness and side effects in lung cancer treatment.
Objective: Pyrotinb has been approved for the treatment of HER2-positive advanced or metastatic breast cancer in China. However, the plasma concentration of pyrotinb in different patients varies greatly, and in the course of treatment, if patients have intolerable adverse reactions, the drug dosage will be reduced or even stopped. This study set out to establish an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the determination of pyrotinb in human plasma, analyze the population pharmacokinetics (PPK) of pyrotinib and assess the influence of patient variables on PK of pyrotinib in patients with HER2 positive breast cancer.
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- EGFR-TKIs like icotinib, osimertinib, and aumolertinib are effective treatments for non-small cell lung cancer (NSCLC) in patients with EGFR mutations, and anlotinib is used alongside them as an anti-angiogenic agent.
- A new method using ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed to simultaneously measure the levels of these drugs in patient blood samples.
- The assay has shown strong performance metrics such as selectivity, accuracy, and repeatability, confirming its reliability for clinical monitoring of these medications' concentrations in patients.
Purpose: To develop an UPLC-MS/MS method for the quantitative analysis of pentoxifylline in beagle dog plasma and apply it to a pharmacokinetic study of food effect.
Methods: Sample separation was achieved using a Kinetex Phenyl-Hexyl column (50 × 2.1 mm, 1.